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Akademický článek

Comprehensive metabolomic characterization of atrial fibrillation

Autor: Chengcan Lu, Chunyan Liu, Di Mei, Mengjie Yu, Jian Bai, Xue Bao, Min Wang, Kejia Fu, Xin Yi, Weihong Ge, Jizhong Shen, Yuzhu Peng, Wei Xu

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundUsing human humoral metabolomic profiling, we can discover the diagnostic biomarkers and pathogenesis of disease. The specific characterization of atrial fibrillation (AF) subtypes with metabolomics may facilitate effective and targeted tre

Externí odkaz: https://doaj.org/article/8b426a449ae44ddf9061ff699cacf010

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Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS

Autor: Yueying Bian, Mengqi Sun, Huili Chen, Guanghui Ren, Kejia Fu, Nan Yang, Mei Zhang, Nan Zhou, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen, Di Zhao

Publikováno v: Xenobiotica. 52:165-176

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3259d6f32e2acb31d745580ec4f890af
https://doi.org/10.1080/00498254.2021.2014080

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Development of a sensitive UPLC-MS/MS assay for domperidone and pharmacokinetics of domperidone tablet formulations in fasting and fed Chinese healthy subjects

Autor: Yuntong Zhai, Xijing Chen, Changqing Yang, Zhiying Qin, Caie Wang, Guanghui Ren, Kejia Fu, Chengcan Lu

Publikováno v: Int. Journal of Clinical Pharmacology and Therapeutics. 58:177-182

Objective The objective of this study was to evaluate and compare the pharmacokinetics of domperidone tablets in Chinese healthy subjects both under fasting and fed conditions. Materials and methods A total of 36 subjects were recruited to the monoce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b7a24ec02b6b993ee3397b5019e90a
https://doi.org/10.5414/cp203529

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Permeability and transport mechanism of trihexyphenidyl hydrochloride in Caco-2 cell monolayer model with a validated UPLC-MS/MS method

Autor: Yang Lu, Ning Li, Chengcan Lu, Di Zhao, Kejia Fu, Jiali Wei, Jing Zhou, Xijing Chen, Kangna Cao, Yongjie Zhang

Publikováno v: Journal of pharmaceutical and biomedical analysis. 178

A rapid and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was applied to investigate the permeability characteristics and transport mechanism of trihexyphenidyl hydrochloride (TH) in D-hanks with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055111347da8bd45ce486a36947e1534
https://pubmed.ncbi.nlm.nih.gov/31672580

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Interactions between Oroxylin A with the solute carrier transporters and ATP-binding cassette transporters: Drug transporters profile for this flavonoid

Autor: Yang Lu, Yongjie Zhang, Guanghui Ren, Di Zhao, Kejia Fu, Huili Chen, Zhiying Qin, Nan Yang, Xijing Chen, Chengcan Lu, Ning Li

Publikováno v: Chemico-Biological Interactions. 324:109097

Oroxylin A is a flavonoid monomer extracted from Scutellaria baicalensis Georgi with neuroprotective, anti-tumor activity and many other biological functions. However, the interaction between Oroxylin A and the drug transporters has not been clearly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e38b1a5dcf2b58721f0d6af427e59f2
https://doi.org/10.1016/j.cbi.2020.109097

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