Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Keizo Sugasawa"'
Autor:
Fukushi Hirayama, Keizo Sugasawa, Yoshiyuki Iwatsuki, Tsukasa Ishihara, Yuji Koga, Kenichi Mori
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:6324-6332
The blood coagulation cascade represents an attractive target for antithrombotic drug development, and recent studies have attempted to identify oral anticoagulants with inhibitory activity for enzymes in this cascade, with particular attention focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7f3bd10af509e6a8d6e5522106f88f
https://doi.org/10.1016/j.bmc.2014.09.059
https://doi.org/10.1016/j.bmc.2014.09.059
Autor:
Yuzo Matsumoto, Yuji Koga, Norio Seki, Kenichi Mori, Tsukasa Ishihara, Yumiko Moritani, Ryouta Shiraki, Takeshi Kadokura, Yoshiyuki Iwatsuki, Shuichi Sakamoto, Takeshi Shigenaga, Hiroyuki Koshio, Keizo Sugasawa, Shunichiro Hachiya, Fukushi Hirayama, Shin-ichi Tsukamoto, Tomihisa Kawasaki
Publikováno v:
Journal of Medicinal Chemistry. 54:8051-8065
Inhibitors of factor Xa (FXa), a crucial serine protease in the coagulation cascade, have attracted a great deal of attention as a target for developing antithrombotic agents. We previously reported findings from our optimization study of a high-thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8a6c40b5439d83acb06a80b263695a
https://doi.org/10.1021/jm200868m
https://doi.org/10.1021/jm200868m
Autor:
Tomihisa Kawasaki, Fukushi Hirayama, Yuji Koga, Keizo Sugasawa, Chinatsu Sakata, Shin Naganuma, Masaki Abe, Hiroyuki Itoh, Ken-ichi Suzuki
Publikováno v:
European Journal of Pharmacology. 650:58-63
Eltrombopag, an orally-active small molecule thrombopoietin (TPO) receptor agonist, was used for the first time in 2008 to treat patients with chronic idiopathic thrombocytopenic purpura. Here, we investigated the pharmacological effect of a new oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a59b4cd368612ed5a0d14f02d99102
https://doi.org/10.1016/j.ejphar.2010.09.072
https://doi.org/10.1016/j.ejphar.2010.09.072
Autor:
Tomihisa Kawasaki, Masaki Abe, Fukushi Hirayama, Ken-ichi Suzuki, Mari Fukushima-Shintani, Yoshiyuki Iwatsuki, Keizo Sugasawa
Publikováno v:
Experimental Hematology. 36:1337-1342
Objective AKR-501 (YM477) is an orally active thrombopoietin (TPO) receptor agonist that mimics the biological effect of TPO in vitro and in vivo. Here, we report that AKR-501 in combination with TPO has additive effect on megakaryocytopoiesis. Mater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4971ceb0245d606c7ed53a5dcd231c8e
https://doi.org/10.1016/j.exphem.2008.04.020
https://doi.org/10.1016/j.exphem.2008.04.020
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 49:468-472
Using chiral bidentate lithium amides having a bulky group instead of a phenyl group on the chiral carbon, enantioselective deprotonation of prochiral 4-substituted cyclohexanones in the presence of excess trimethylsilyl chloride was examined in THF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50ecc437d78a71b1ab18055ae67e8257
https://doi.org/10.1248/cpb.49.468
https://doi.org/10.1248/cpb.49.468
Publikováno v:
Tetrahedron Letters. 38:567-570
Enantioselective deprotonation of 4-substituted cyclohexanones (1) in the presence of excess trimethylsilyl chloride was examined using chiral bidentate lithium amides ((R)-3∼(R)-7) in THF. The solution structures of (R)-3a in THF in the presence a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::306f3835aab0a51787ad23ee00248cc6
https://doi.org/10.1016/s0040-4039(96)02373-8
https://doi.org/10.1016/s0040-4039(96)02373-8
Autor:
Keizo Sugasawa, Olena Taratula, John Psonis, Ivan J. Dmochowski, Amos B. Smith, Zhengzheng Liao, Brian P. Weiser, Daniel J. Emerson, Xiaozhao Wang, Ashley Fiamengo, Roderic G. Eckenhoff
Recently, we identified 1-aminoanthracene as a fluorescent general anesthetic. To investigate the mechanism of action, a photoactive analogue, 1-azidoanthracene, was synthesized. Administration of 1-azidoanthracene to albino stage 40-47 tadpoles was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131c88c937568d09aef14d277e55739d
https://europepmc.org/articles/PMC3671381/
https://europepmc.org/articles/PMC3671381/
Publikováno v:
Tetrahedron Letters. 37:7377-7380
Enantioselectivity of deprotonation reaction of 4-tert-butylcyclohexanone (2) by a monodentate chiral lithium amide ( (R,R)- 1 ) in THF is strongly influenced by the presence of lithium halides. Aggregation states of this chiral lithium amide in THF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a31f78c9f8b1919da393ce763b59c260
https://doi.org/10.1016/0040-4039(96)01681-4
https://doi.org/10.1016/0040-4039(96)01681-4
Publikováno v:
ChemInform. 28
Enantioselective deprotonation of 4-substituted cyclohexanones (1) in the presence of excess trimethylsilyl chloride was examined using chiral bidentate lithium amides ((R)-3∼(R)-7) in THF. The solution structures of (R)-3a in THF in the presence a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::073adda93685f3c87465646adb653efc
https://doi.org/10.1002/chin.199717059
https://doi.org/10.1002/chin.199717059
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3b663959177e146a5ce4ba4e5e0b4c0
https://doi.org/10.1002/chin.200139086
https://doi.org/10.1002/chin.200139086