Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Keizo Maita"'
Autor:
Keizo Maita, Yasufumi Shutoh, Makio Takeda, Yutaka Komatsu, Atsuko Haishima, Takanori Harada, Ryoichi Ohtsuka, Hideaki Fujie, Satoru Yamaguchi
Publikováno v:
The Journal of Toxicological Sciences. 34:469-482
To verify the relationship between oxidative stress and DNA methylation in the young brain, dichlorodiphenyltrichloroethane (DDT) was administered by gavage to male young rats at doses of 0, 0.006, 0.06, 0.6, 6, and 60 mg/kg/day for a period of 4 wee
Autor:
Junya Sasaki, Toshinori Yoshida, Tadashi Kosaka, Yukiko Takeuchi, Yuko Chiba, Keizo Maita, Makio Takeda, Sayuri Kojima, Ryoichi Ohtsuka, Sayaka Ishimine, Takanori Harada, Maki Kuwahara, Naofumi Takahashi, Koichi Hayashi
Publikováno v:
Journal of Toxicologic Pathology. 18:89-98
We previously demonstrated that rat offspring exposed perinatally to methoxychlor (MXC) still exhibited immunotoxic changes in young adulthood at 10 weeks of age. That result led us to further investigate whether the influence of perinatal exposure t
Autor:
Maki Kuwahara, Keizo Maita, Takanori Harada, Tadashi Kosaka, Kayoko Sugimoto, Kosei Inui, Naofumi Takahashi, Yukiko Kashimoto
Publikováno v:
The Journal of Toxicological Sciences. 29:187-193
Testosterone propionate (TP) was supplemented to male rats for assessment of its ameliorating effect on testicular toxicity with thiamphenicol (TAP). A total of 20 male Sprague-Dawley rats were treated orally with TAP at 200 mg/kg/day for up to 4 wee
Autor:
Toshinori Yoshida, Makio Takeda, Ryoichi Ohtsuka, Maki Kuwahara, Keizo Maita, Naofumi Takahashi, Yukiko Takeuchi, Yuko Chiba, Koichi Hayashi, Takanori Harada, Tadashi Kosaka, Sayaka Ishimine
Publikováno v:
Journal of Toxicologic Pathology. 17:165-170
Autor:
Yukiko Kashimoto, Maki Kuwahara, Keizo Maita, Tadashi Kosaka, Kayoko Sugimoto, Naofumi Takahasi, Kosei Inui, Takanori Harada
Publikováno v:
Journal of Toxicologic Pathology. 16:67-75
A total of 30 male Sprague-Dawley rats were treated orally with thiamphenicol (TAP) at 200 mg/kg/day for up to 4 weeks followed by 10 weeks recovery. At each week of treatment, 5 of them were examined weights of the testis and accessory genital gland
Autor:
Takanori Harada, Makio Takeda, Yukiko Takeuchi, Koichi Hayashi, Shoji Teramoto, Keizo Maita, Tadashi Kosaka, Toshinori Yoshida, Hideki Fujisawa
Publikováno v:
Toxicology Letters. 135:199-207
The effect of Methoxychlor (MXC) on the thymus was examined in rat pups that were delivered from dams receiving MXC at a dietary concentration of 0 or 1500 ppm for a period from pregnancy to lactation. The pups of both sexes were euthanized on postna
Autor:
Keizo Maita, Yukiko Takeuchi, Maki Kuwahara, Takanori Harada, Makio Takeda, Masayoshi Kuwahara
Publikováno v:
Virchows Archiv. 438:492-497
We investigated whether transforming growth factor beta (TGF-beta) is involved in the growth of malignant mesothelioma (MM) cells in culture. TGF-beta production was examined in two mesothelioma cell lines (MeET-4 and -6) that were established from r
Autor:
Fuyuko Yoshida, Keizo Maita, Satoshi Nagata, Yoshio Ueno, Toshinori Yoshida, Tomoaki Tsutsumi, Makio Takeda, Takanori Harada
Publikováno v:
Journal of Toxicologic Pathology. 14:259-265
The aim of this study was to examine tumor necrosis factor-α (TNF-α) expression and Kupffer cell activation in hepatotoxicity caused by microcystin-LR (MCLR). Mice received a single intraperitoneal injection of 60.0 μg/kg MCLR and were killed at s
Autor:
Satoshi Nagata, Toshinori Yoshida, Yoshio Ueno, Keizo Maita, Fuyuko Yoshida, Takanori Harada, Tomoaki Tsutsumi
Publikováno v:
Journal of Toxicologic Pathology. 14:205-212
We described the use of image analysis for determination of the intralobular distribution of microcystin-LR (L, L-leucine and R, L-arginine) and compared the results with liver injuries. Gray level was measured in each intralobular region and convert
Autor:
Yoshio Ueno, Keizo Maita, Tomoaki Tsutsumi, Yumi Nakamura, Toshinori Yoshida, Fuyuko Yoshida, Satoshi Nagata, Takanori Harada
Publikováno v:
Journal of Toxicologic Pathology. 14:157-161
A cyanobacterial toxin, microcystin-LR (MCLR), is a potent inhibitor of protein phosphatase that disrupts cytoskeleton network in hepatocytes. Conventional transmission electron and immunoelectron microscopic studies were conducted in the liver from