Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Keizo, Tokuhiro"'
Autor:
Keita Fujiwara, Tadashi Inoue, Aya Kimoto, Jiang Zixian, Keizo Tokuhiro, Yoshiki Yasukochi, Tomoya O. Akama, Chen-Leng Cai, Ichiro Shiojima, Hiroshi Kimura, Shige H. Yoshimura, Tomoyuki Nakamura, Maretoshi Hirai
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 115048- (2024)
Summary: Cardiomyocyte (CM) nuclei are constantly exposed to mechanical stress, but how they maintain their nuclear shape remains unknown. In this study, we found that ventricular CM nuclei acquire characteristic prominent spatial organizations of he
Externí odkaz:
https://doaj.org/article/8ae6e71d01dd4681aaaba4f71d36cebc
Autor:
Tuyen Thi Thanh Nguyen, Keizo Tokuhiro, Keisuke Shimada, Haoting Wang, Daisuke Mashiko, Shingo Tonai, Daiji Kiyozumi, Masahito Ikawa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Since the advent of gene-targeting technology in embryonic stem cells, mice have become a primary model organism for investigating human gene function due to the striking genomic similarities between the two species. With the introduction of the CRIS
Externí odkaz:
https://doaj.org/article/59a84543f26d45b08df96f46bbe39f22
Autor:
Anh Hoang Pham, Chihiro Emori, Yu Ishikawa-Yamauchi, Keizo Tokuhiro, Maki Kamoshita, Yoshitaka Fujihara, Masahito Ikawa
Publikováno v:
Cells, Vol 13, Iss 10, p 802 (2024)
Infertility is considered a global health issue as it currently affects one in every six couples, with female factors reckoned to contribute to partly or solely 50% of all infertility cases. Over a thousand genes are predicted to be highly expressed
Externí odkaz:
https://doaj.org/article/10fc31a375564485a4e494ebab4414a2
Autor:
Yuji Kamioka, Yoshihiro Ueda, Naoyuki Kondo, Keizo Tokuhiro, Yoshiki Ikeda, Wolfgang Bergmeier, Tatsuo Kinashi
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112580- (2023)
Summary: Bidirectional control of integrin activation plays crucial roles in cell adhesive behaviors, but how integrins are specifically regulated by inside-out and outside-in signaling has not been fully understood. Here, we report distinct bidirect
Externí odkaz:
https://doaj.org/article/572c60ac01bb4250aa1301d0e89a3ef6
Autor:
Yuki Oyama, Haruhiko Miyata, Keisuke Shimada, Yoshitaka Fujihara, Keizo Tokuhiro, Thomas X Garcia, Martin M Matzuk, Masahito Ikawa
Publikováno v:
Asian Journal of Andrology, Vol 24, Iss 3, Pp 266-272 (2022)
Gene expression analyses suggest that more than 1000–2000 genes are expressed predominantly in mouse and human testes. Although functional analyses of hundreds of these genes have been performed, there are still many testis-enriched genes whose fun
Externí odkaz:
https://doaj.org/article/7f88ba8a95df47dfb5206782c6123575
Autor:
Hiromitsu Tanaka, Keizo Tokuhiro
Publikováno v:
Cell Journal, Vol 24, Iss 9, Pp 552-554 (2022)
HASPIN is a nuclear serine-threonine kinase originally identified in the mouse testis. Its 193 bp DNA promoter element(hereafter, 193PE) regulates bidirectional, synchronous gene expression in the germ cells of male mice. Recent studieshave shown tha
Externí odkaz:
https://doaj.org/article/1c73c16342a142fcac91d383cbcf882e
Publikováno v:
Biology, Vol 12, Iss 2, p 320 (2023)
The MATP/tau protein is hyperphosphorylated in Alzheimer’s patients. Therefore, research into the regulation of tau protein phosphorylation is important for understanding Alzheimer’s disease. HASPIN is a serine/threonine kinase that is expressed
Externí odkaz:
https://doaj.org/article/94ba20f9ae994c44b2e3fba721281c4d
Autor:
Tuyen Thi Thanh Nguyen, Keizo Tokuhiro, Keisuke Shimada, Haoting Wang, Daisuke Mashiko, Shingo Tonai, Daiji Kiyozumi, Masahito Ikawa
Publikováno v:
Frontiers in Cell & Developmental Biology; 2024, p1-12, 12p
Autor:
Edgar-John Vogt, Keizo Tokuhiro, Min Guo, Ryan Dale, Guanghui Yang, Seung-Wook Shin, Maria Jimenez Movilla, Hari Shroff, Jurrien Dean
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Mammalian eggs require a single sperm for viable fertilization, and cortical granule exocytosis prevents additional sperm binding. Vogt et al. image at single granule resolution to document that cortical granule anchoring in the cortex ensures proper
Externí odkaz:
https://doaj.org/article/e6424900b9c54c2f9956c43155b7d5da
Autor:
Hisayo Nishida-Fukuda, Keizo Tokuhiro, Yukio Ando, Hiroaki Matsushita, Morimasa Wada, Hiromitsu Tanaka
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249912 (2021)
HASPIN is a serine/threonine kinase that regulates mitosis by phosphorylating histone H3 at threonine 3. The expression levels of HASPIN in various cancers are associated with tumor malignancy and poor survival, suggesting that HASPIN inhibition may
Externí odkaz:
https://doaj.org/article/971e560ede6544d8ba3b85b8214cf81c