Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Keito Okazaki"'
Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
Autor:
Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, Hiroshi Kitamura, Yoshiaki Onodera, Md. Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Shu Tadaka, Ikuko Motoike, Mika Watanabe, Kazuki Hayasaka, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Aberrant activation of NRF2 in cancer cells contributes to tumorigenicity and therapeutic resistance. Here, the authors show that NRF2 cooperates with CEBPB and remodels enhancers to confer tumor-initiating activity on NRF2- activated non-small cell
Externí odkaz:
https://doaj.org/article/e2fd0ce97bcb4b3aabb6a909e9e673dd
Autor:
Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, Hiroshi Kitamura, Yoshiaki Onodera, Md. Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Shu Tadaka, Ikuko Motoike, Mika Watanabe, Kazuki Hayasaka, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-20927-9.
Externí odkaz:
https://doaj.org/article/139e41cc1a864ed2a000c137c48e2d9e
Autor:
Keito Okazaki, Hayato Anzawa, Fumiki Katsuoka, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi
Publikováno v:
The Journal of Biochemistry. 171:567-578
NRF2 is a transcription activator that plays a key role in cytoprotection against oxidative stress. Although increased NRF2 activity is principally beneficial for our health, NRF2 activation in cancer cells is detrimental, as it drives their malignan
Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
Autor:
Kazuki Hayasaka, Yoshiaki Onodera, Mika Watanabe, Yoshinori Okada, Md. Morshedul Alam, Nao Ota, Akira Sakurada, Kengo Kinoshita, Hozumi Motohashi, Keito Okazaki, Shu Tadaka, Takuma Suzuki, Masayuki Yamamoto, Hayato Anzawa, Ikuko N. Motoike, Takashi Suzuki, Fumiki Katsuoka, Zun Liu, Hiroki Sekine, Hiroshi Kitamura, Daisuke Matsumaru
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
Transcriptional dysregulation, which can be caused by genetic and epigenetic alterations, is a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2, is often aberrantly activated in non-small cell lung cancers (NS
Publikováno v:
Biophysical Reviews
The KEAP1-NRF2 system is a sulfur-employing defense mechanism against oxidative and electrophilic stress. NRF2 is a potent transcription activator for genes mediating sulfur-involving redox reactions, and KEAP1 controls the NRF2 activity in response
Enhancer Remodeling Promotes Tumor-Initiating Activity in NRF2-Activated Non-Small Cell Lung Cancers
Autor:
Md. Morshedul Alam, Shu Tadaka, Daisuke Matsumaru, Nao Ota, Yoshinori Okada, Takuma Suzuki, Hiroki Sekine, Zun Liu, Fumiki Katsuoka, Hozumi Motohashi, Masayuki Yamamoto, Hayato Anzawa, Takashi Suzuki, Yoshiaki Onodera, Keito Okazaki, Akira Sakurada, Kengo Kinoshita, Mika Watanabe, Hiroshi Kitamura, Ikuko N. Motoike
SummaryTranscriptional dysregulation, which can be caused by genetic and epigenetic alterations, is a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2, is often aberrantly activated in non-small cell lung canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfc9389d6d8c1ba2b0f896480aac2d3
Autor:
Nao Ota, Linh Nguyen, Hiroki Sekine, Keito Okazaki, Hiroshi Kitamura, Md. Morshedul Alam, Kazuhiko Igarashi, Hiroki Shima, Hozumi Motohashi, Shohei Murakami
Publikováno v:
Journal of Biological Chemistry. 292:7519-7530
NRF2 (nuclear factor erythroid 2-related factor 2) is a key transcriptional activator that mediates the inducible expression of antioxidant genes. NRF2 is normally ubiquitinated by KEAP1 (Kelch-like ECH-associated protein 1) and subsequently degraded
Autor:
Mitsuhiro Ito, Norio Suzuki, Yasutake Katoh, Keito Okazaki, Hozumi Motohashi, Kazuhiko Igarashi, Hiroki Sekine, Nao Ota, Masayuki Yamamoto, Hiroki Shima
Publikováno v:
Molecular and cellular biology. 36(3)
The KEAP1-NRF2 system plays a central role in cytoprotection. NRF2 is stabilized in response to electrophiles and activates transcription of antioxidant genes. Although robust induction of NRF2 target genes confers resistance to oxidative insults, ho
O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1.
Autor:
Hiroki Sekine, Keito Okazaki, Koichiro Kato, Alam, M. Morshedul, Hiroki Shima, Fumiki Katsuoka, Tadayuki Tsujita, Norio Suzuki, Akira Kobayashi, Kazuhiko Igarashi, Masayuki Yamamoto, Hozumi Motohashi
Publikováno v:
Molecular & Cellular Biology; Sep2018, Vol. 38 Issue 17, p1-21, 21p