Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Keito Hoshitsuki"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAsparaginase (ASNase) is a crucial part of acute leukemia treatment, but immune responses to the agent can reduce its effectiveness and increase the risk of relapse. Currently, no reliable and validated biomarker predicts ASNase-induced hyp
Externí odkaz:
https://doaj.org/article/0bd814965dee4a029936fa2c86e71ce9
Autor:
Gundala Venkata Naveen Kumar, Keito Hoshitsuki, Sanjay Rathod, Manda J. Ramsey, Lauren Kokai, Erin E. Kershaw, Wen Xie, Christian A. Fernandez
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3779-3790 (2021)
PEGylated-l-asparaginase (PEG-ASNase) is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia (ALL). Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis, with obesity and older age co
Externí odkaz:
https://doaj.org/article/030f734db6814ff9a311d060430fa2e6
Autor:
Aboli Bhingarkar, Hima V. Vangapandu, Sanjay Rathod, Keito Hoshitsuki, Christian A. Fernandez
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Amino acid (AA) metabolism plays an important role in many cellular processes including energy production, immune function, and purine and pyrimidine synthesis. Cancer cells therefore require increased AA uptake and undergo metabolic reprogramming to
Externí odkaz:
https://doaj.org/article/ff8a01113fdd4ca48c72b357f0870b54
Publikováno v:
Frontiers in Immunology; 2024, p1-10, 10p
Autor:
Erick R. Scott, Yao Yang, Mariana R. Botton, Yoshinori Seki, Keito Hoshitsuki, John Harting, Primo Baybayan, Neal Cody, Paola Nicoletti, Takaya Moriyama, Shreyasee Chakraborty, Jun J. Yang, Lisa Edelmann, Eric E. Schadt, Jonas Korlach, Stuart A. Scott
Publikováno v:
Human Mutation. 43:1557-1566
To determine the phase of NUDT15 sequence variants for more comprehensive star (*) allele diplotyping, we developed a novel long-read single-molecule real-time HiFi amplicon sequencing method. A 10.5 kb NUDT15 amplicon assay was validated using refer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f406ff4b322204b3cd3c5d435891ee5
https://doi.org/10.1002/humu.24457
https://doi.org/10.1002/humu.24457
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb54072b8f234a2557241c803bb07627
https://doi.org/10.1124/jpet.122.156500
https://doi.org/10.1124/jpet.122.156500
Autor:
Wenjian Yang, Seth E. Karol, Keito Hoshitsuki, Shawn Lee, Eric C. Larsen, Naomi Winick, William L. Carroll, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Stuart S. Winter, Kimberly P. Dunsmore, Meenakshi Devidas, Mary V. Relling, Jun J. Yang
Publikováno v:
JAMA network open. 5(12)
ImportanceAcute lymphoblastic leukemia (ALL) is the most common childhood cancer. Hepatotoxic effects, including hyperbilirubinemia and elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, are common during all phases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5128fa697a881516a1fc1ef7d8066f19
https://pubmed.ncbi.nlm.nih.gov/36580335
https://pubmed.ncbi.nlm.nih.gov/36580335
Autor:
Takaya Moriyama, Karen R. Rabin, Jeffery M. Klco, Rebekah Baskin-Doerfler, Charles G. Mullighan, Katherine Verbist, Ninad Oak, Jun J. Yang, Kim E. Nichols, Rina Nishii, Keito Hoshitsuki, Mignon L. Loh, Zhenhua Li, Maoxiang Qian, Elizabeth A. Raetz, Allen Eng Juh Yeoh, Mackenzie Bloom, Stephen P. Hunger, Monika L. Metzger, Xujie Zhao, Wentao Yang, Wenjian Yang, Jinghui Zhang, Scott Newman, Julie M. Gastier-Foster, Melissa A. Burns, Gang Wu, Ting-Nien Lin, Ching-Hon Pui
Publikováno v:
Blood. 137:364-373
There is growing evidence supporting an inherited basis for susceptibility to acute lymphoblastic leukemia (ALL) in children. In particular, we and others reported recurrent germline ETV6 variants linked to ALL risk, which collectively represent a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a13e78449aecfa40b786a3679941e19
https://doi.org/10.1182/blood.2020006164
https://doi.org/10.1182/blood.2020006164
Autor:
Chi Kong Li, Smita Bhatia, Yung-Li Yang, Wentao Yang, Pål Stenmark, Emma Rose Scaletti, James R Goodhand, Minu Singh, C. H. Li, Keito Hoshitsuki, Motohiro Kato, Takaya Moriyama, Jun J. Yang, Gareth J. Walker, Mary V. Relling, Colton Smith, Tariq Ahmad, Hiroki Hori, Wenjian Yang, Allen Eng Juh Yeoh, Prateek Bhatia, Nicholas A. Kennedy, Deepa Bhojwani, Kenneth A. Matreyek, Douglas M. Fowler, Rina Nishii, Federico Antillon Klussmann, Lie Li, Amita Trehan, Chase C. Suiter, Chris Parish, Liz Y P Yuen
Publikováno v:
Proceedings of the National Academy of Sciences. 117:5394-5401
As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs. Recently, NUDT15 deficiency was identified as a gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f46bae116226cd42ca77248453b307c
https://doi.org/10.1073/pnas.1915680117
https://doi.org/10.1073/pnas.1915680117
Autor:
Hiroto Inaba, Patricia J. Barker, Alejandro R Molinelli, Jeffrey E. Rubnitz, Keito Hoshitsuki
Publikováno v:
Clin Chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae4ed69558f2bac668f01a6198f189f
https://doi.org/10.1093/clinchem/hvz035
https://doi.org/10.1093/clinchem/hvz035