Zobrazeno 1 - 8
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pro vyhledávání: '"Keith Y. Abe"'
Publikováno v:
Surgery. 122:273-280
Background. Acute flow-induced arterial dilation is mediated by nitric oxide (NO). The role of NO in chronic flow-induced adaptive enlargement is unknown. We assessed the role of NO in arterial adaptation to increased blood flow (BF). Methods. Iliac
Publikováno v:
Biochemical and Biophysical Research Communications. 234:289-292
Hepatocyte expression of inducible nitric oxide synthase (iNOS) is initiated by the presence of pro-inflammatory cytokines, such as interleukin-1beta (IL-1). In the presence of oxidative stress, IL-1beta mediated hepatocyte iNOS expression and NO syn
Autor:
Keith Y. Abe, Paul C. Kuo
Publikováno v:
Surgery. 120:309-314
Background. In a system of rat hepatocytes in primary culture, inhibition of cytokine-mediated nitric oxide (NO) production has been shown to be protective in states of oxidative stress. In the absence of oxidative injury, inhibition of NO synthesis
Publikováno v:
Transplantation. 61:305-312
Nitric oxide (NO) is a multifunctional free radical with a variety of described biochemical and physiological roles. The immunologic relationships between organ transplantation and NO synthesis are unknown. While a number of in vitro and in vivo mode
Publikováno v:
Surgery. 118:310-317
Background. Although nitric oxide synthase (NOS) is a cytochrome P450-like hemoprotein with additional sequence homology to cytochrome P450 reductase, the role of the cytochrome P450 system in cytokine-mediated NO synthesis is unknown. Methods. To ch
Autor:
Keith Y. Abe, Yong Jie Zhuang, Toshiki Sasaki, Tej M. Singh, Hirotake Masuda, Christopher K. Zarins
Publikováno v:
The Journal of surgical research. 77(2)
Arteries enlarge in response to increased blood flow, but the molecular signals controlling this enlargement are not well understood. Basic fibroblast growth factor (bFGF) is a potent mitogen for endothelial cells (EC) and smooth muscle cells (SMC) a
Autor:
Paul C. Kuo, Keith Y. Abe
Publikováno v:
Gastroenterology. 109(1)
Background & Aims: Nitric oxide modifies free radical-mediated cell processes in multiple in vivo and in vitro systems. The aim of this study was to determine the role of hepatocyte production of NO in oxidative injury. Methods: Rat hepatocytes in pr
Autor:
Keith Y. Abe, Paul C. Kuo
Publikováno v:
FEBS Letters. (1):10-14
To investigate the role of the cytochrome P-450 sys- tem in NO synthesis, cytochrome P-450IIIA, IIE and IA activi- ties were specifically inhibited by cimetidine (IIIA), clotrimazole (IIIA), benzoflavone (IA) and disulfiram (IIE) in a model of cultur