Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Keith W. Ward"'
Autor:
Keith W. Ward, Chun-Yue I. Lee, Sarabjit S Gahir, Mitsumasa Sakamoto, Scott A. Reisman, Joel W. Proksch
Publikováno v:
Drug Design, Development and Therapy. 13:1259-1270
Background Omaveloxolone is a synthetic oleanane triterpenoid that pharmacologically activates Nrf2, a master transcription factor that regulates genes with antioxidative, anti-inflammatory, and mitochondrial bioenergetic properties, and is being eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c218317af4d50940f3be3d79f04b58
https://doi.org/10.2147/dddt.s193889
https://doi.org/10.2147/dddt.s193889
Autor:
Scott A, Reisman, Sarabjit S, Gahir, Chun-Yue I, Lee, Joel W, Proksch, Mitsumasa, Sakamoto, Keith W, Ward
Publikováno v:
Drug Design, Development and Therapy
Background Omaveloxolone is a synthetic oleanane triterpenoid that pharmacologically activates Nrf2, a master transcription factor that regulates genes with antioxidative, anti-inflammatory, and mitochondrial bioenergetic properties, and is being eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f45cee680b7bd7f75d3159099274880
https://pubmed.ncbi.nlm.nih.gov/31118567
https://pubmed.ncbi.nlm.nih.gov/31118567
Autor:
Jamieson Jann, Iok-Hou Pang, Hongli Wu, Christy Xavier, Keith W. Ward, Abbot F. Clark, Xiaobin Liu
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 98-109 (2016)
Redox Biology
Redox Biology
Graphical abstract
Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD). Previous studies have shown that RTA 408, a synthetic triterpenoid com
Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD). Previous studies have shown that RTA 408, a synthetic triterpenoid com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e222fbd5018d0f4ab1fced9e19b7f7d
https://doi.org/10.1016/j.redox.2015.12.005
https://doi.org/10.1016/j.redox.2015.12.005
Autor:
Colin J. Meyer, Jennifer L. Wilkinson-Berka, Keith W. Ward, Devy Deliyanti, Steven Petratos, Judy B. de Haan, Jae Young Lee
Publikováno v:
Clinical Science. 130:1375-1387
An imbalance in oxidative stress and antioxidant defense mechanisms contributes to the development of ischaemic retinopathies such as diabetic retinopathy and retinopathy of prematurity (ROP). Currently, the therapeutic utility of targeting key trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33ea54c9bc0001e063482618e0ed9f3
https://doi.org/10.1042/cs20160068
https://doi.org/10.1042/cs20160068
Autor:
Devy Deliyanti, Colin J. Meyer, Judy B. de Haan, Saeed F. Alrashdi, Jennifer L. Wilkinson-Berka, Keith W. Ward, Sih Min Tan
Publikováno v:
Investigative ophthalmologyvisual science. 59(2)
Purpose Oxidative stress is a causal factor in the development of diabetic retinopathy; however, clinically relevant strategies to treat the disease by augmenting antioxidant defense mechanisms have not been fully explored. We hypothesized that boost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838090dda0703cc94759bad08aba4815
https://pubmed.ncbi.nlm.nih.gov/29411009
https://pubmed.ncbi.nlm.nih.gov/29411009
Autor:
Arpeeta Sharma, Mark E. Cooper, Keith W. Ward, Tom C. Karagiannis, Sih Min Tan, Derek Y.C. Yuen, Nada Stefanovic, Judy B. de Haan, Colin J. Meyer
Publikováno v:
Diabetes. 63:3091-3103
Oxidative stress and inflammation are inextricably linked and play essential roles in the initiation and progression of diabetes complications such as diabetes-associated atherosclerosis and nephropathy. Bolstering antioxidant defenses is an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de329945293102e6038c65b2317c54fa
https://doi.org/10.2337/db13-1743
https://doi.org/10.2337/db13-1743
Autor:
Hao Yan, Patricia Fernández-Llama, Robert H. Christenson, David R. Plowchalk, David K. Packham, Xiaofang Yu, David B. Kingsmore, He Zhang, Joachim H. Ix, Cristina Esteva-Font, Michael W. Steffes, Yi Fang, Samuel A. Silver, Lori A. Plum, Maurizio Postorino, Jade J. Wong-You-Cheong, Jonathan G. Fox, Ziv Harel, Francesco U.S. Mattace-Raso, Ying Hang, Scott A. Reisman, Colin J. Meyer, Sokratis Stoumpos, Thomas C. Dowling, Marisa Battistella, Julia B. Zella, Hui Zhang, Xiaoxiao Yang, Francesca Mallamaci, Elena Guillén-Gómez, Stephen L. Seliger, J.M. Díaz, José Ballarín, Emma Aitken, Tongqiang Liu, David G. Warnock, George L. Bakris, Robert M. Richardson, Luis Guirado, Matthew R. Weir, Nosratola D. Vaziri, C Facundo, Graziella D'Arrigo, Hector F. DeLuca, Claudia Torino, Megan O'Grady, Laurence S. Magder, Zhaohui Ni, Kathryn K. Stevens, Ayse L. Mindikoglu, Shaopeng Liu, Jan L.C.M. van Saase, Marc Clancy, Giovanni Tripepi, Jiaqi Qian, Melanie P. Chin, Druckerei Stückle, Xiaoqiang Ding, Wei Fang, Emily C. Charlesworth, Peter A. McCullough, Margaret Clagett-Dame, Carmine Zoccali, Satz Mengensatzproduktion, William R. Hutson, Keith W. Ward, Rocco Tripepi, Colin C. Geddes, Aiwu Lin, Elisabet Ars, Jeffrey Perl, Michael Potochoiba, Madhumathi Rao, Jieru Cai, Bingying Zhang, Jiaying Huang, Andrew G. Bostom, Peter G. Linde
Publikováno v:
American Journal of Nephrology. 39:I-VI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdfe7d1315f097fa5c6af265741145b2
https://doi.org/10.1159/000365231
https://doi.org/10.1159/000365231
Publikováno v:
Archives of Dermatological Research. 306:447-454
RTA 408 is a member of the synthetic oleanane triterpenoid class of compounds known to potently activate the cytoprotective transcription factor Nrf2. Because skin is constantly exposed to external oxidative stress, such as that from ultraviolet radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c326b6e29eb0a1b4f064db54c1cee138
https://doi.org/10.1007/s00403-013-1433-7
https://doi.org/10.1007/s00403-013-1433-7
Publikováno v:
Drug Metabolism and Disposition. 39:1181-1187
Mapracorat is a selective glucocorticoid receptor agonist in development for the treatment of a variety of ocular diseases. The purpose of this investigation was to evaluate the ocular pharmacokinetics of mapracorat after topical dosing over a range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1cff9222828b7a88b3693ac2a3e9b5
https://doi.org/10.1124/dmd.111.039099
https://doi.org/10.1124/dmd.111.039099