Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Keith W. Rickert"'
Autor:
Hans Layman, Keith W Rickert, Susan Wilson, Anastasia A Aksyuk, Jill M Dunty, Dusit Natrakul, Nithya Swaminathan, Christopher J DelNagro
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229672 (2020)
More than 170 types of human papilloma viruses (HPV) exist with many causing proliferative diseases linked to malignancy in indications such as cervical cancer and head and neck squamous cell carcinoma. Characterization of antibody levels toward HPV
Externí odkaz:
https://doaj.org/article/1cc40719378244fdb98fe4a48e91e7fc
Autor:
Daniel A Cannon, Lu Shan, Qun Du, Lena Shirinian, Keith W Rickert, Kim L Rosenthal, Martin Korade, Lilian E van Vlerken-Ysla, Andrew Buchanan, Tristan J Vaughan, Melissa M Damschroder, Bojana Popovic
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1006980 (2019)
Antibodies are an important class of therapeutics that have significant clinical impact for the treatment of severe diseases. Computational tools to support antibody drug discovery have been developing at an increasing rate over the last decade and t
Externí odkaz:
https://doaj.org/article/5c50a244ed204541b31f7ba74cb15714
Autor:
Gabriela M. Marchetti, Jennifer Cann, Keith W Rickert, Ruchi Gupta, Weiguang Zhao, Qing Li, Jonathan T. Boyd, Richard N. Hanna, Timothy Burwell, Herren Wu, M. Jack Borrok, William Dall'acqua, Joseph Grimsby, Emily L. Ongstad, Norman C. Peterson, Ping Tsui, Maureen Kennedy
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-10 (2019)
Communications Biology
Communications Biology
Systemic administration of bio-therapeutics can result in only a fraction of drug reaching targeted tissues, with the majority of drug being distributed to tissues irrelevant to the drug’s site of action. Targeted delivery to specific organs may al
Autor:
Christopher J. DelNagro, Susan Wilson, Dusit Natrakul, Hans Layman, Anastasia A. Aksyuk, Jill M. Dunty, Nithya Swaminathan, Keith W. Rickert
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229672 (2020)
PLoS ONE
PLoS ONE
More than 170 types of human papilloma viruses (HPV) exist with many causing proliferative diseases linked to malignancy in indications such as cervical cancer and head and neck squamous cell carcinoma. Characterization of antibody levels toward HPV
Autor:
Norman C. Peterson, Jason White, Keith W Rickert, M. Jack Borrok, Kevin L Allen, William Dall'acqua, Lu Shan, Ping Tsui, Kyle Kuszpit, Richard N. Hanna, Qing Li, Arnita Barnes, Herren Wu
Publikováno v:
Molecular Pharmaceutics.
Targeted strategies to deliver and retain drugs to kidneys are needed to improve drug accumulation and efficacy in a myriad of kidney diseases. These drug delivery systems show potential for improving the therapeutic windows of drugs acting in the ki
Autor:
Qing, Li, Norman, Peterson, Richard N, Hanna, Kyle, Kuszpit, Jason, White, Kevin L, Allen, Arnita, Barnes, Keith W, Rickert, Lu, Shan, Herren, Wu, William F, Dall'Acqua, Ping, Tsui, M Jack, Borrok
Publikováno v:
Molecular pharmaceutics. 17(2)
Targeted strategies to deliver and retain drugs to kidneys are needed to improve drug accumulation and efficacy in a myriad of kidney diseases. These drug delivery systems show potential for improving the therapeutic windows of drugs acting in the ki
Autor:
William Dall'acqua, Kevin L Allen, Keith W Rickert, Jason White, Kim Rosenthal, Ping Tsui, Norman C. Peterson, Qing Li, Chris Lloyd, Xizhe Gao, M. Jack Borrok, Herren Wu
Publikováno v:
Journal of Controlled Release. 279:126-135
The accumulation, dissemination and clearance of monoclonal antibody-based therapeutics or imaging reagents targeting tumor associated antigens is governed by several factors including affinity, size, charge, and valency. Tumor targeting antibody fra
Autor:
Daniel R. Higazi, Michael A. Bowen, Nicholas J. Bond, Rebecca Dunmore, Lynne Murray, William Dall'acqua, Yanli Wu, Jie Zhu, Toyin Kasali, M. Jack Borrok, Lena Shirinian, Arnita Barnes, Catherine Huntington, Sandrina Phipps, John Hood, Emilie Solier, Ping Tsui, Keith W Rickert, Alan M. Carruthers
Publikováno v:
mAbs. 9:104-113
Excessive transforming growth factor (TGF)-β is associated with pro-fibrotic responses in lung disease, yet it also plays essential roles in tissue homeostasis and autoimmunity. Therefore, selective inhibition of excessive and aberrant integrin-medi
Autor:
Jia Lin, Herren Wu, Vaheh Oganesyan, André H. St. Amant, Daniel Lemen, Javier Read de Alaniz, Shenlan Mao, Changshou Gao, Marcello Marelli, R. James Christie, Jay Harper, Keith W. Rickert, Fengying Huang
Publikováno v:
Angew Chem Int Ed Engl
Here, we describe a diene-containing noncanonical amino acid (ncAA) capable of undergoing fast and selective normal electron-demand Diels–Alder (DA) reactions following its incorporation into antibodies. A cyclopentadiene derivative of lysine (CpHK
Autor:
Balakumar Vijayakrishnan, Qing Li, Philip Howard, M. Jack Borrok, Arnaud C. Tiberghien, Keith W Rickert, Allison M. Barrett, Kevin L Allen, Changshou Gao, Ping Tsui, William Dall'acqua, R Jim Christie, Jay Harper, Marcello Marelli, Rhiannon Beard, Herren Wu
Publikováno v:
Bioconjugate chemistry. 30(4)
Despite some clinical success with antibody-drug conjugates (ADCs) in patients with solid tumors and hematological malignancies, improvements in ADC design are still desirable due to the narrow therapeutic window of these compounds. Tumor-targeting a