The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor

Autor: Danny Legge, Ling Li, Whei Moriarty, David Lee, Marianna Szemes, Asef Zahed, Leonidas Panousopoulos, Wan Yun Chung, Yara Aghabi, Jasmin Barratt, Richard Williams, Kathy Pritchard‐Jones, Karim T.A. Malik, Sebastian Oltean, Keith W. Brown

Publikováno v: Molecular Oncology, Vol 16, Iss 3, Pp 630-647 (2022)

Wilms tumour (WT), an embryonal kidney cancer, has been extensively characterised for genetic and epigenetic alterations, but a proportion of WTs still lack identifiable abnormalities. To uncover DNA methylation changes critical for WT pathogenesis,

Externí odkaz: https://doaj.org/article/4fdb93ca44e444e2810400925199bb7a

Correction: Frequent Long-Range Epigenetic Silencing of Protocadherin Gene Clusters on Chromosome 5q31 in Wilms' Tumor.

Autor: Anthony R. Dallosso, Anne L. Hancock, Marianna Szemes, Kim Moorwood, Laxmi Chilukamarri, Hsin-Hao Tsai, Abby Sarkar, Jonathan Barasch, Raisa Vuononvirta, Chris Jones, Kathy Pritchard-Jones, Brigitte Royer-Pokora, Sean Bong Lee, Ceris Owen, Sally Malik, Yi Feng, Marcus Frank, Andrew Ward, Keith W. Brown, Karim Malik

Publikováno v: PLoS Genetics, Vol 5, Iss 12 (2009)

Externí odkaz: https://doaj.org/article/12cff33d5872435d98ea3c6115388187

Data from Frequency and Timing of Loss of Imprinting at 11p13 and 11p15 in Wilms' Tumor Development

Autor: Karim T.A. Malik, Adrian K. Charles, Beth Moore, Frances Power, Keith W. Brown

Epigenetic changes occur frequently in Wilms' tumor (WT), especially loss of imprinting (LOI) of IGF2/H19 at 11p15. Our previous results have identified imprinted transcripts (WT1-AS and AWT1) from the WT1 locus at 11p13 and showed LOI of these in so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5124f64b0d1108090e527dcf3804e65
https://doi.org/10.1158/1541-7786.c.6542083

Author response for 'The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor'

Autor: Asef Zahed, Keith W. Brown, Danny Legge, David A. Lee, Whei Moriarty, Ling Li, Wan Yun Chung, Karim Malik, Richard D. Williams, Jasmin Barratt, Sebastian Oltean, Kathy Pritchard-Jones, Leonidas Panousopoulos, Marianna Szemes, Yara Aghabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf8b5bf5d11692f1307cfb2fe01d61dd
https://doi.org/10.1002/1878-0261.13101/v2/response1

Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes

Autor: Jessica Charlet, Keith W. Brown, Karim Malik, Bader Almutairi, Heather C. Etchevers, Anthony R. Dallosso, Marianna Szemes

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, pp.18934. ⟨10.1038/s41598-019-55382-6⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Almutairi, B, Charlet, J, Dallosso, A R, Szemes, M, Etchevers, H C, Malik, K T A & Brown, K W 2019, ' Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes ', Scientific Reports, vol. 9, 18934 (2019) . https://doi.org/10.1038/s41598-019-55382-6

International audience; To discover epigenetic changes that may underly neuroblastoma pathogenesis, we identified differentially methylated genes in neuroblastoma cells compared to neural crest cells, the presumptive precursors cells for neuroblastom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635a067218f3e90574140fe1ebd29da0
https://doi.org/10.1038/s41598-019-55382-6