Zobrazeno 1 - 10
of 370
pro vyhledávání: '"Keith W, Muir"'
Autor:
Brad J. Kolls, Keith W. Muir, Sean I. Savitz, Lawrence R. Wechsler, Julie G. Pilitsis, Scott Rahimi, Richard L. Beckman, Vincent Holmes, Peng R. Chen, David S. Albers, Daniel T. Laskowitz
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Recruitment of participants is the greatest risk to completion of most clinical trials, with 20–40% of trials failing to reach the targeted enrollment. This is particularly true of trials of central nervous system (CNS) therapie
Externí odkaz:
https://doaj.org/article/c3732c3a4d014d00a0a506ffb4de9cef
Autor:
Graeme A. Keith, Rosemary A. Woodward, Tracey Hopkins, Sarah Allwood-Spiers, Jon Trinder, Keith W. Muir, David A. Porter, Natasha E. Fullerton
Publikováno v:
IPEM-Translation, Vol 9, Iss , Pp 100025- (2024)
Clinical translation of 7 tesla (T) MRI of the brain promises high image quality and potentially improved clinical diagnosis for patients compared to current standard lower field-strength MRI at 1.5 and 3T.Here we describe how physics principles unde
Externí odkaz:
https://doaj.org/article/acd2e44e556743e1a66d8d545b15bc10
Autor:
Daniel P.O. Kaiser, Thanh N. Nguyen, Bruce C.V. Campbell, Jeffrey L. Saver, Diederik W.J. Dippel, Andrew M. Demchuk, Charles B.L.M. Majoie, Scott B. Brown, Peter J. Mitchell, Johannes C. Gerber, Serge Bracard, Francis Guillemin, Tudor G. Jovin, Keith W. Muir, Philip White, Daniela Schoene, Michael D. Hill, Mayank Goyal, Volker Puetz
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 3, Iss 6 (2023)
Background The optimal management of patients with symptomatic isolated internal carotid artery (ICA) occlusion is unknown. We aimed to assess whether endovascular treatment (EVT) compared with standard medical care was associated with improved funct
Externí odkaz:
https://doaj.org/article/e2f74877e1174657a0d62b810f1e4f97
Autor:
Jesse Dawson, Michele Robertson, David Alexander Dickie, Phillip Bath, Kirsten Forbes, Terence Quinn, Niall M. Broomfield, Krishna Dani, Alex Doney, Graeme Houston, Kennedy R. Lees, Keith W. Muir, Allan Struthers, Matthew Walters, Mark Barber, Ajay Bhalla, Alan Cameron, Alexander Dyker, Paul Guyler, Ahamad Hassan, Mark T. Kearney, Breffni Keegan, Sekaran Lakshmanan, Mary Joan Macleod, Marc Randall, Louise Shaw, Ganesh Subramanian, David Werring, Alex McConnachie
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101863- (2023)
Summary: Background: People who experience an ischaemic stroke are at risk of recurrent vascular events, progression of cerebrovascular disease, and cognitive decline. We assessed whether allopurinol, a xanthine oxidase inhibitor, reduced white matte
Externí odkaz:
https://doaj.org/article/6db3a982a110424586003c813c4bb452
Autor:
Alina Königsberg, Andrew T. DeMarco, Carola Mayer, Anke Wouters, Eckhard Schlemm, Martin Ebinger, Tae-Hee Cho, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Ivana Galinovic, Josep Puig, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Christian Gerloff, Götz Thomalla, Bastian Cheng
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Stroke has a deleterious impact on quality of life. However, it is less well known if stroke lesions in different brain regions are associated with reduced quality of life (QoL). We therefore investigated this association by multivariate les
Externí odkaz:
https://doaj.org/article/ef6466db0e0e48a889fbf97510930dbd
Autor:
Eckhard Schlemm, Thies Ingwersen, Alina Königsberg, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Ivana Galinovic, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Josep Puig, Claus Z. Simonsen, Vincent Thijs, Anke Wouters, Christian Gerloff, Götz Thomalla, Bastian Cheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The effects of thrombolysis therapy in stroke on structural connectivity are not well understood. Here, the authors show with causal mediation analysis that the clinical benefits of thrombolysis in anterior circulation stroke are mediated via structu
Externí odkaz:
https://doaj.org/article/57258b4e8c144513a87b692fc69385cf
Autor:
Patrick Schrempf, Hannah Watson, Eunsoo Park, Maciej Pajak, Hamish MacKinnon, Keith W. Muir, David Harris-Birtill, Alison Q. O’Neil
Publikováno v:
Machine Learning and Knowledge Extraction, Vol 3, Iss 2, Pp 299-317 (2021)
Training medical image analysis models traditionally requires large amounts of expertly annotated imaging data which is time-consuming and expensive to obtain. One solution is to automatically extract scan-level labels from radiology reports. Previou
Externí odkaz:
https://doaj.org/article/3bf3f00c3bb94930aaf4518364a33889
Autor:
Ewgenia Barow, Fanny Quandt, Bastian Cheng, Mathias Gelderblom, Märit Jensen, Alina Königsberg, Florent Boutitie, Norbert Nighoghossian, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Vincent Thijs, Robin Lemmens, Keith W. Muir, Salvador Pedraza, Claus Z. Simonsen, Christian Gerloff, Götz Thomalla
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
IntroductionHigher white blood cell (WBC) count is associated with poor functional outcome in acute ischemic stroke (AIS). However, little is known about whether the association is modified by treatment with intravenous alteplase.MethodsWAKE-UP was a
Externí odkaz:
https://doaj.org/article/36114f0a069146e582ccc35b59b0ddc2
Autor:
Benedikt M. Frey, Florent Boutitie, Bastian Cheng, Tae-Hee Cho, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Ian Ford, Ivana Galinovic, Alina Königsberg, Josep Puig, Pascal Roy, Anke Wouters, Tim Magnus, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Christian Gerloff, Götz Thomalla, on behalf of the WAKE-UP investigators
Publikováno v:
Neurological Research and Practice, Vol 2, Iss 1, Pp 1-9 (2020)
Abstract Background One quarter to one third of patients eligible for systemic thrombolysis are on antiplatelet therapy at presentation. In this study, we aimed to assess the safety and efficacy of intravenous thrombolysis in stroke patients on presc
Externí odkaz:
https://doaj.org/article/a2681b52279b4872b84f253b8e7f4f50
Autor:
Ewgenia Barow, Hans Pinnschmidt, Florent Boutitie, Alina Königsberg, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Christian Gerloff, Götz Thomalla, Bastian Cheng, on behalf of the WAKE-UP investigators
Publikováno v:
Neurological Research and Practice, Vol 2, Iss 1, Pp 1-7 (2020)
Abstract Background The anatomical distribution of acute lacunar infarcts has mainly been studied for supratentorial lesions. In addition, little is known about the association with distinct stroke symptoms, not summarized as classical lacunar syndro
Externí odkaz:
https://doaj.org/article/977b8c9663e74d4db8e601862d8df2f5