Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Keith Vosseller"'
Publikováno v:
The Journal of biological chemistry, vol 292, iss 22
O-GlcNAcylation is the covalent addition of an O-linked β-N-acetylglucosamine (O-GlcNAc) sugar moiety to hydroxyl groups of serine/threonine residues of cytosolic and nuclear proteins. O-GlcNAcylation, analogous to phosphorylation, plays critical ro
Autor:
Keith Vosseller, Andrew V. Kossenkov, Gianluca Gallo, Ashley Landicho, Robert J. Chalkley, Yuliya Skorobogatko
Publikováno v:
Journal of Biological Chemistry. 289:3602-3612
O-GlcNAc is a carbohydrate modification found on cytosolic and nuclear proteins. Our previous findings implicated O-GlcNAc in hippocampal presynaptic plasticity. An important mechanism in presynaptic plasticity is the establishment of the reserve poo
Publikováno v:
Journal of Biological Chemistry. 288:15121-15130
Cancer cell metabolic reprogramming includes a shift in energy production from oxidative phosphorylation to less efficient glycolysis even in the presence of oxygen (Warburg effect) and use of glutamine for increased biosynthetic needs. This necessit
Autor:
Sri S. Kanaparthy, Matthew R. Arkebauer, Keith Vosseller, Vance G. Nielsen, Saninuj N. Malayaman
Publikováno v:
Blood Coagulation & Fibrinolysis. 22:712-719
Cigarette smoke and carbon monoxide (CO) released from tricarbonyldichlororuthenium (II) dimer (CORM-2) attenuate fibrinolysis. The purpose of the present study was to determine whether CO diminished fibrinolysis by enhancement of α₂-antiplasmin v
Autor:
Matthew R. Arkebauer, Dipty Mangla, Sheldon B. Gomes, Kesavan Sadacharam, Kimberly Wasko, Keith Vosseller, Vance G. Nielsen, Nikhil Chawla
Publikováno v:
Blood Coagulation & Fibrinolysis. 22:756-759
Administration of carbon monoxide derived from carbon monoxide-releasing molecules has been demonstrated to enhance coagulation in vitro at small concentrations (100-200 μmol/l) in human and rabbit plasma. We sought to determine if carbon monoxide-r
Autor:
Keith Vosseller, Yuliya Skorobogatko, Thomas Clark, David J. Vocadlo, Scott A. Yuzwa, Anuj K. Yadav
Publikováno v:
Amino Acids. 40:857-868
The microtubule-associated protein tau is known to be post-translationally modified by the addition of N-acetyl-D: -glucosamine monosaccharides to certain serine and threonine residues. These O-GlcNAc modification sites on tau have been challenging t
Autor:
Yuliya Skorobogatko, Kelly A. Whelan, Neal Varghis, David J. Vocadlo, Melanie K. Tallent, Keith Vosseller, Lisa Hernandez-Cuebas
Publikováno v:
Journal of Biological Chemistry. 284:174-181
O-Linked N-acetylglucosamine (O-GlcNAc) is a cytosolic and nuclear carbohydrate post-translational modification most abundant in brain. We recently reported uniquely extensive O-GlcNAc modification of proteins that function in synaptic vesicle releas
Autor:
David J. Vocadlo, Keith Vosseller, Katherine Kollins, Gianluca Gallo, Neal Varghis, Herb Francisco
Publikováno v:
Developmental Neurobiology
Many neuronal cytosolic and nuclear proteins are post-translationally modified by the reversible addition of O-linked N-acetylglucosamine (O-GlcNAc) on serines and threonines. The cellular functions of O-GlcNAc modifications in neuronal development a
Autor:
Gerald W. Hart, Lance Wells, Hiroshi Hirano, Yoshihiro Akimoto, Shinya Nagamatsu, Keith Vosseller, Hayato Kawakami, Koji Yamamoto, Mica Ohara-Imaizumi, Chiyono Nishiwaki, Eiji Munetomo
Publikováno v:
Glycobiology. 17:127-140
Many nuclear and cytoplasmic proteins are O-glycosylated on serine or threonine residues with the monosaccharide beta-N-acetylglucosamine, which is then termed O-linked N-acetylglucosamine (O-GlcNAc). It has been shown that abnormal O-GlcNAc modifica
Autor:
Keith Vosseller, Jonathan C. Trinidad, Alma L. Burlingame, Lance Wells, Robert J. Chalkley, Kirk C. Hansen, Gerald W. Hart
Publikováno v:
PROTEOMICS. 5:388-398
While phosphorylation and O-GlcNAc (cytoplasmic and nuclear glycosylation) are linked to normal and pathological changes in cell states, these post-translational modifications have been difficult to analyze in proteomic studies. We describe advances