Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Keith V. Alsaker"'
Publikováno v:
Biotechnology and Bioprocess Engineering. 10:432-443
Microarray technology has contributed significantly to the understanding of bacterial genetics and transcriptional regulation. One neglected aspect of this technology has been optimization of microarray-generated signals and quality of generated info
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aeb2bfd6d0cc561d574038b5275f03a
https://doi.org/10.1007/bf02989826
https://doi.org/10.1007/bf02989826
Publikováno v:
Systems Metabolic Engineering ISBN: 9789400745339
We discuss experimental and computational systems-biology approaches to support the development of more toxic-metabolite tolerant strains, with emphasis on solventogenic clostridia. We also discuss ideas that have the potential to move the field towa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7b4bdb40cefaeb8059f90e15f0b7dcf
https://doi.org/10.1007/978-94-007-4534-6_7
https://doi.org/10.1007/978-94-007-4534-6_7
Publikováno v:
Biotechnology and bioengineering. 105(6)
Metabolite accumulation has pleiotropic, toxic, or beneficial effects on cell physiology, but such effects are not well understood at the molecular level. Cells respond and adapt to metabolite stress by mechanisms largely unexplored, especially in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695a1e778f3c8a1d63052e3534b84f40
https://pubmed.ncbi.nlm.nih.gov/19998280
https://pubmed.ncbi.nlm.nih.gov/19998280
Publikováno v:
Nature reviews. Microbiology. 3(12)
Clostridia are anaerobic, endospore-forming prokaryotes that include strains of importance to human and animal health and physiology, cellulose degradation, solvent production and bioremediation. Their differentiation and related developmental progra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e80b4190c397f1809e81ecfbf179396
https://pubmed.ncbi.nlm.nih.gov/16261177
https://pubmed.ncbi.nlm.nih.gov/16261177
DNA microarray analysis of Clostridium acetobutylicum was used to examine the genomic-scale gene expression changes during the shift from exponential-phase growth and acidogenesis to stationary phase and solventogenesis. Self-organizing maps were use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37bc10da4357f36f3fa8bf8d9dec3804
https://europepmc.org/articles/PMC1251621/
https://europepmc.org/articles/PMC1251621/
Publikováno v:
Journal of bacteriology. 186(7)
Spo0A is the regulator of stationary-phase events and is required for transcription of solvent formation genes in Clostridium acetobutylicum . In order to elucidate the role of spo0A in differentiation, we performed transcriptional analysis of 824(pM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeeea7602ea7de800c7f0404ec661eac
https://pubmed.ncbi.nlm.nih.gov/15028679
https://pubmed.ncbi.nlm.nih.gov/15028679
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(3)
An intuitive normalization and gene identification method is proposed. After segmentation of the entire expression range into intensity intervals, the mean and standard deviation of the logarithm of expression ratios are calculated for each interval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f78ff3fa852c9af3e6040f66bf93dac
https://pubmed.ncbi.nlm.nih.gov/12529501
https://pubmed.ncbi.nlm.nih.gov/12529501
Autor:
Hendrik P. J. Bonarius, He Yang, Carlos J. Paredes, Wouter T. Hendriksen, Christopher A. Tomas, Keith V. Alsaker, Jeffrey A. Beamish, Eleftherios T. Papoutsakis
Publikováno v:
Journal of Bacteriology, 185(15), 4539-4547. American Society for Microbiology
The large-scale transcriptional program of two Clostridium acetobutylicum strains (SKO1 and M5) relative to that of the parent strain (wild type [WT]) was examined by using DNA microarrays. Glass DNA arrays containing a selected set of 1,019 genes (i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33fd520154452ae613718922a5da016
https://pure.eur.nl/en/publications/555b7aed-5007-474c-8302-3dc70aed238b
https://pure.eur.nl/en/publications/555b7aed-5007-474c-8302-3dc70aed238b