Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Keith T. Schmidt"'
Autor:
Ilana Schlam, D. Max Smith, Cody Peer, Tristan Sissung, Keith T. Schmidt, Ming Tan, Ami Chitalia, Nanette H. Bishopric, Seth Steinberg, Hyoyoung Choo-Wosoba, Giulia Napoli, Christopher Gallagher, Nadia Ashai, Kristen Whitaker, Candace Mainor, Shruti Tiwari, Nicole Swanson, Stacy Malloy, Claudine Isaacs, William Douglas Figg, Sandra M. Swain
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Underrepresented populations’ participation in clinical trials remains limited, and the potential impact of genomic variants on drug metabolism remains elusive. This study aimed to assess the pharmacokinetics (PK) and pharmacogenomics (PGx
Externí odkaz:
https://doaj.org/article/ad6ed8bebf71498f80dbc2876ee15de4
Autor:
Yang Li, Yan Jin, Hanieh Taheri, Keith T. Schmidt, Alice A. Gibson, Stefan A. J. Buck, Eric D. Eisenmann, Ron H. J. Mathijssen, William D. Figg, Sharyn D. Baker, Alex Sparreboom, Shuiying Hu
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1933 (2022)
In recent years, various endogenous compounds have been proposed as putative biomarkers for the hepatic uptake transporters OATP1B1 and OATP1B3 that have the potential to predict transporter-mediated drug–drug interactions (DDIs). However, these co
Externí odkaz:
https://doaj.org/article/f5ac3357508f42909be4461d3b90d944
Autor:
Joyson J. Karakunnel, Nam Bui, Latha Palaniappan, Keith T. Schmidt, Kenneth W. Mahaffey, Briggs Morrison, William D. Figg, Shivaani Kummar
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract Background With the exception of genotoxic oncology drugs, first-in-human, Phase 1 clinical studies of investigational drugs have traditionally been conducted in healthy volunteers (HVs). The primary goal of these studies is to investigate t
Externí odkaz:
https://doaj.org/article/82b0410fbfbb4a57994b7c8206a1d584
Autor:
Andrea Sikora Newsome, Said Sultan, Brian Murray, Samuel W. Jones, Ashley Pappas, Keith T. Schmidt, Guillaume Filteau, Jeffrey P. Laux, Adam Wolfe, Felicia Williams, Bruce A. Cairns
Publikováno v:
Burns Open, Vol 1, Iss 2, Pp 49-53 (2017)
Objective: Inhalation injury is an independent risk factor for mortality in burn patients. The purpose of this study was to observe the effect of inhaled iloprost on gas exchange in patients with inhalation injury and acute respiratory failure as mea
Externí odkaz:
https://doaj.org/article/936406c67dea4afab10e5335c83277c5
Autor:
Cody J. Peer, Keith T. Schmidt, Oluwatobi Arisa, William J. Richardson, Koosha Paydary, Daniel A. Goldstein, James L. Gulley, William D. Figg, Mark J. Ratain
Publikováno v:
The Journal of Clinical Pharmacology. 63:672-680
Autor:
William D. Figg, Douglas K. Price, Tristan M. Sissung, Alwin D.R. Huitema, Jonathan D. Strope, Cindy H. Chau, Keith T. Schmidt
Effective treatments for patients with metastatic castration-resistant prostate cancer following disease progression on enzalutamide are currently an unmet clinical need. Simultaneous inhibition of the hypoxia-inducible factor (HIF)-1α and androgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4ba6e147cfcb816efb72fe5c1b4299
https://doi.org/10.1158/1535-7163.c.6543360
https://doi.org/10.1158/1535-7163.c.6543360
Autor:
William D. Figg, Douglas K. Price, Tristan M. Sissung, Alwin D.R. Huitema, Jonathan D. Strope, Cindy H. Chau, Keith T. Schmidt
Figures S1, S2, S3, S4, and S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a54046cb40fd1b0426d5193dae7c7ca
https://doi.org/10.1158/1535-7163.22522386.v1
https://doi.org/10.1158/1535-7163.22522386.v1
Publikováno v:
Nature Reviews Urology. 18:209-226
The introduction of second-generation androgen receptor antagonists (SG-ARAs) has greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious alternatives to chemotherapy. SG-ARAs provide similar therapeutic bene
Autor:
Linda Sciuto, Yves Pommier, Cody J. Peer, William D. Figg, Thomas P. C. Dorlo, Lisa M. Cordes, Anish Thomas, Susan Wroblewski, Alwin D. R. Huitema, Keith T. Schmidt, Ravi A. Madan
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose NLG207 (formerly CRLX101) is a nanoparticle–drug conjugate (NDC) of the potent topoisomerase I inhibitor, camptothecin (CPT). The present study sought to characterize the complex pharmacokinetics (PK) of NLG207 and better describe CPT relea
Publikováno v:
Cancer Biology & Therapy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The adrenal-restrictive HSD3B1(1245A) allele limits extragonadal dihydrotestosterone synthesis, whereas the adrenal-permissive HSD3B1(1245C) allele augments extragonadal dihydrotestosterone synthesis. Retrospective studies have suggested an associati