Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Keith T. Holland"'
Autor:
Keith T. Holland, Zaed Z R Hamady, J. Peter A. Lodge, Nigel Scott, Mark D. Farrar, Robin Thorpe, P. Dilger, Meenu Wadhwa, Simon R. Carding, Terence R. Whitehead
Publikováno v:
Inflammatory Bowel Diseases. 17:1925-1935
BACKGROUND: While cytokine therapy and the use of immunosuppressive cytokines such as transforming growth factor-? (TGF-?) offer great potential for the treatment of inflammatory bowel disease (IBD), issues concerning formulation, stability in vivo,
Publikováno v:
FEMS Microbiology Letters. 290:149-155
Staphylococcus epidermidis is a commensal on skin, whereas Staphylococcus aureus is a transient pathogen. The aim was to determine whether the skin's innate defence systems responded differently to these microorganisms. Differential gene expression o
Autor:
Terence R. Whitehead, Zaed Z R Hamady, J. Peter A. Lodge, Mark D. Farrar, Simon R. Carding, Keith T. Holland
Publikováno v:
Microbiology. 154:3165-3174
The use of genetically modified bacteria to deliver biologically active molecules directly to the gut has become an increasingly attractive area of investigation. The challenge of regulation of production of the therapeutic molecule and colonization
Publikováno v:
Medical Mycology. 36:97-106
Publikováno v:
FEMS Microbiology Letters. 279:110-115
This was a preliminary investigation to define the conditions of colonization of a human skin equivalent (SE) model with cutaneous microorganisms. SEs of 24 mm diameter were constructed with a dermal matrix of fibrin containing fibroblasts and a stra
Publikováno v:
Plasmid. 58:68-75
A cryptic plasmid, pPG01 (3539bp), was isolated from Propionibacterium granulosum and sequenced. Analysis of open reading frames (ORFs) predicted pPG01 to encode three proteins. The largest protein (447 amino acids) showed homology to the FtsK/SpoIII
Publikováno v:
British Journal of Dermatology. 110:593-599
SUMMARY Correlation matrices were constructed for various human skin variables (propionibacteria, micrococcaceae, sebum excretion rate, percentage of free fatty acids and free fatty acid production rate). Two independent populations were studied (n=
Autor:
R.A. Bojar, Keith T. Holland
Publikováno v:
Clinics in Dermatology. 22:375-379
The involvement of microorganisms in the development of acne has a long and checkered history. Just over 100 years ago, Propionibacterium acnes (then known as Bacillus acnes) was isolated from acne lesions, and it was suggested that P. acnes was invo
Publikováno v:
Letters in Applied Microbiology. 38:470-475
Aims: A wide range of lipids are present on the skin surface of human beings and bacterial lipases are known to modify them. The microflora of the underarm (axilla) is often dominated by aerobic coryneforms and whilst many require lipids for growth,
Publikováno v:
Microbiology. 150:2005-2013
The hyaluronate lyase (HL) gene ofStaphylococcus aureus8325-4 (hysA) was inactivatedin vitrowith the insertion of the erythromycin determinant,ermC, from plasmid pE194. ThehysA : : ermCmutation was introduced intoS. aureusvia a temperature-sensitive