Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Keith T. Garnes"'
Publikováno v:
Journal of Chemical Research. 36:351-355
PF-00217830 is a D2-partial agonist developed for the treatment of schizophrenia. The dual 14C/14C and 14C/3H-labelled PF-00217830 were required for animal and human absorption, distribution, metabolism and elimination (ADME) studies. This report des
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:166-170
β-amino acids 1 and 2 are α2δ agonists, which were developed for the treatment of generalized anxiety disorder and insomnia. The stable and radioactive isotope-labeled β-amino acids were required to support pre-clinical and clinical studies. Asym
Autor:
Maura Agostini, Stephen O'Rahilly, Timothy M. Willson, David B. Savage, H. Eric Xu, Keith T. Garnes, John W.R. Schwabe, Odelia Rajanayagam, Aaron G. Smith, Mark Gurnell, V. Krishna K. Chatterjee, Emily M. Wood, Sidney H. Levinson
Publikováno v:
Endocrinology. 145:1527-1538
Loss-of-function mutations in the ligand-binding domain of human peroxisome proliferator-activated receptor gamma (PPARgamma) are associated with a novel syndrome characterized by partial lipodystrophy and severe insulin resistance. Here we have furt
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:1025-1033
Transition metal-activated borohydride exchange resin and borodeuteride exchange resin have been prepared and used for the selective reductive deuteration of aryl bromides. This methodology, which utilizes deuterated methanol as the primary source of
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 42:77-81
The 125 I-labeled cephalosporin amide I was prepared via chloramine-T-mediated iodo-tin exchange of the tributyltin precursor 2.
Autor:
A. J. Villani, Arthur Y. L. Shu, S. G. Senderoff, Keith T. Garnes, D. Saunders, S. H. Levinson, J. R. Heys, W. Chen
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 39:291-298
The tritium exchange labeling of a variety of complex compounds is achieved in the presence of catalyst precursor [(cod)Ir(PPh 3 ) 1 ]BF 4 and limited amounts of tritium gas. The regioselectivity of exchange is high and consistent with empirical rule
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 38:637-643
The pyridinyl imidazole cytokine-suppressing anti-inflammatory drug (CSAID), SB 206718 (1) was required in 125 I-labeled form for photoaffinity ligand studies. The target compound (SB 206718-[ 125 I], [ 125 I]1) was obtained via conversion of the hig
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:1091-1105
Carvedilol (SK&F 105517) possesses unique cardiovascular activity, and is under development for indications such as angina and hypertension. Tritium labeled enantiomers of Carvedilol and racemates of three metabolites were needed for pharmacologic an
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 29:891-902
1-(4-Chloro-[3-3H]benzyl) -3-(t-butylthio)-a, a-dimethyl-5-(i-propyl) -indole-2-propanoic acid (10, MK-886) was prepared by catalytic tritium/halogen exchange on 1-(4-chloro-3-iodobenzyl)-3-(t-butylthio)-a,a -dimethyl-5-(i-propyl)-indole-2-propanoic
Autor:
Scott W. Landvatter, J. Richard Heys, Jerry L. Adams, Joseph Sisko, Larry A. Davis, Keith T. Garnes
Publikováno v:
Isotope Production and Applications in the 21st Century.