Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Keith T. Akama"'
Autor:
Teresa A. Milner, Murat Yildirim, John H. Morrison, Wendy Lou, William G.M. Janssen, Bruce S. McEwen, Keith T. Akama
Publikováno v:
Brain Research. 1379:98-108
The estrogen 17β-estradiol (E) increases the axospinous synaptic density and plasticity in the hippocampal CA1 region of young female rats but fails to do so in aged female rats. This E stimulus on synaptic plasticity is associated with the phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e183463586739efa12dcc1935e389ec4
https://doi.org/10.1016/j.brainres.2010.07.053
https://doi.org/10.1016/j.brainres.2010.07.053
Publikováno v:
Reviews in the Neurosciences. 18:1-14
Since the first finding that 17beta-estradiol (E) can regulate CA1 pyramidal cell synapse formation, subsequent studies have explored many potential E-dependent mechanisms occurring within CA1 pyramidal cells. Fewer studies have focused on E-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f701acdb79e5bb42f40a7db7b238e2
https://doi.org/10.1515/revneuro.2007.18.1.1
https://doi.org/10.1515/revneuro.2007.18.1.1
Autor:
Jolanta Gorecka, Hector Zhiyu Ye, Teresa A. Milner, Louisa I. Thompson, Andreina D Gonzales, Bruce S. McEwen, Deborah J. Clegg, Parth Patel, Edward J. Filardo, Elizabeth M. Waters, Keith T. Akama
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(6)
Both estrous cycle and sex affect the numbers and types of neuronal and glial profiles containing the classical estrogen receptors α and β, and synaptic levels in the rodent dorsal hippocampus. Here, we examined whether the membrane estrogen recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa8fb2cbbc8eeddf61454a5615b4517
https://pubmed.ncbi.nlm.nih.gov/25673833
https://pubmed.ncbi.nlm.nih.gov/25673833
Autor:
Bruce S. McEwen, Keith T. Akama
Publikováno v:
Trends in Pharmacological Sciences. 26:169-172
Glucocorticoids are adrenal steroid ‘stress' hormones that are important in normal brain function. However, during conditions of excitotoxic injury to neurons, glucocorticoids can exacerbate cell death. A recent study has developed a ‘trifecta' o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771e985ef354ae6ed05cc524639e9b4d
https://doi.org/10.1016/j.tips.2005.02.004
https://doi.org/10.1016/j.tips.2005.02.004
Autor:
Stephen E. Alves, Keith T. Akama, Sonoko Ogawa, Masayoshi Nomura, Kenneth S. Korach, Donald W. Pfaff, Jan-Åke Gustafsson
Publikováno v:
Neuroscience. 130:445-456
We examined the distribution of estrogen receptor (ER)-alpha and ER-beta immunoreactive (ir) cells in the dorsal (DRN) and median/paramedian (MPRN) raphe nuclei in male mice. ER-alpha ir neurons were scattered across the three subdivisions (ventral,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890ba22d2f1de16c954285a69f26f3cb
https://doi.org/10.1016/j.neuroscience.2004.09.028
https://doi.org/10.1016/j.neuroscience.2004.09.028
Publikováno v:
Neuroendocrinology. 80:308-323
17β-Estradiol spatiotemporally regulates the γ-aminobutyric acid (GABAergic) tone in the adult hippocampus. However, the complex estrogenic effect on the GABAergic system is still unclear. In adult central nervous system (CNS) neurons, GABA can ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ff50cbe7e8113e8bcf4c8ac8fdb829
https://doi.org/10.1159/000083657
https://doi.org/10.1159/000083657
Autor:
Bruce S. McEwen, Keith T. Akama
Publikováno v:
The Journal of Neuroscience. 23:2333-2339
Estrogens induce synaptogenesis in the CA1 region of the dorsal hippocampus during the estrous cycle of the female rat. Functional consequences of such estrogen-mediated synaptogenesis include cyclic changes in neurotransmission and memory. At the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94ef9dc4f1d9db9727fedae9b44ba28
https://doi.org/10.1523/jneurosci.23-06-02333.2003
https://doi.org/10.1523/jneurosci.23-06-02333.2003
Publikováno v:
Neuroscience. 122:329-348
Although numerous studies have demonstrated the neurotrophic capacity of gp130 cytokines, it remains unclear whether endogenously expressed cytokines actually function in a direct neuromodulatory manner. Therefore, using the lithium-pilocarpine statu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd6f2019a55670264145703895a11b7
https://doi.org/10.1016/s0306-4522(03)00593-1
https://doi.org/10.1016/s0306-4522(03)00593-1
Autor:
Louis R. Lucas, Li Yun Ma, Kellie L.K. Tamashiro, Randall R. Sakai, Bruce S. McEwen, Lawrence P. Reagan, Keith T. Akama
Publikováno v:
Brain Research. 960:252-258
Tachykinins are a family of neuropeptides that inhibit salt appetite. Although decreased tachykinin-mRNA levels are observed in natriorexic sodium-deplete rats, no decrease is seen in natriorexic sodium-replete rats that are administered the aldoster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8acd716a32204377ec25cfb93f31ea
https://doi.org/10.1016/s0006-8993(02)03908-2
https://doi.org/10.1016/s0006-8993(02)03908-2
Publikováno v:
Neurochemistry International. 39:409-413
Postmortem demonstration of increased expression of biologically active S100B in Alzheimer's disease (AD) and its relation to progression of neuropathological changes across the cortical regions suggests involvement of this astrocytic cytokine in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df555b50750a7b576d8b0c641a6f6bb
https://doi.org/10.1016/s0197-0186(01)00048-1
https://doi.org/10.1016/s0197-0186(01)00048-1