Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Keith Schutsky"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e87180 (2014)
Central nervous system (CNS) metabolic profiles were examined from rabies virus (RABV)-infected mice that were either mock-treated or received post-exposure treatment (PET) with a single dose of the live recombinant RABV vaccine TriGAS. CNS tissue ha
Externí odkaz:
https://doaj.org/article/0ea9a38f6af64ea8b31378f7b174ee79
Publikováno v:
Vaccines, Vol 4, Iss 4, p 43 (2016)
Genomic destabilizers, such as radiation and chemotherapy, and epigenetic modifiers are used for the treatment of cancer due to their apoptotic effects on the aberrant cells. However, these therapies may also induce widespread changes within the immu
Externí odkaz:
https://doaj.org/article/a73a41f698cc40db82ee5bc0298d235d
Autor:
Suzanne Edavettal, Pilar Cejudo-Martin, Bidisha Dasgupta, Danlin Yang, Matthew D. Buschman, Derrick Domingo, Kristof Van Kolen, Pharavee Jaiprasat, Renata Gordon, Keith Schutsky, Brian Geist, Natalie Taylor, Camille Helene Soubrane, Elisabeth Van Der Helm, Ann LaCombe, Zemeda Ainekulu, Eilyn Lacy, Jason Aligo, Jason Ho, Yingbo He, Peter F. Lebowitz, James T. Patterson, Justin M. Scheer, Sanjaya Singh
Publikováno v:
Med (New York, N.Y.). 3(12)
The near impermeability of the blood-brain barrier (BBB) and the unique neuroimmune environment of the CNS prevents the effective use of antibodies in neurological diseases. Delivery of biotherapeutics to the brain can be enabled through receptor-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3625ab074d5c8dc48910447704b3c93b
https://pubmed.ncbi.nlm.nih.gov/36495860
https://pubmed.ncbi.nlm.nih.gov/36495860
Autor:
Nataša Obermajer, Adam Zwolak, Kelly Van De Ven, Shana Versmissen, Aleksandra Brajic, Ted Petley, Dan Weinstock, Jason Aligo, Fang Yi, Stephen Jarantow, Keith Schutsky, Ken Tian, Angelilo Lorraine, Diana Alvarez Arias, Kristel Buyens, Vince Torti, Krista Menard, Katharine Rogers, Brian Geist, Marjolein Van Heerden, Gerald Chu, Bie Verbist, Maté Ongenaert, Julien Hasler, Kathryn Packman, Jacintha Shenton, Dirk Brehmer, Josh Lauring, Regina J. Brown, James Greger, Daphne Salick Ryan, Sanjaya Singh, Matthew V. Lorenzi, Laurie Lenox, Sylvie Laquerre
Publikováno v:
Cancer Research. 82:ND07-ND07
JNJ-78306358 is a first-in-class bispecific antibody (bsAb), engineered using the Zymeworks Azymetric™ platform, to treat advanced stage solid tumors. Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility class I molecule wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec05d991c88124094370dfd690c7319
https://doi.org/10.1158/1538-7445.am2022-nd07
https://doi.org/10.1158/1538-7445.am2022-nd07
Autor:
Daniel J. Powell, M. Kazim Panjwani, Keith Schutsky, Nicola J. Mason, Jenessa B. Smith, Josephine S. Gnanandarajah, Colleen M. O'Connor
Publikováno v:
Molecular Therapy. 24:1602-1614
Preclinical murine models of chimeric antigen receptor (CAR) T cell therapy are widely applied, but are greatly limited by their inability to model the complex human tumor microenvironment and adequately predict safety and efficacy in patients. We th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1884bc59c7543e7b3cdeebd0e9b376b
https://doi.org/10.1038/mt.2016.146
https://doi.org/10.1038/mt.2016.146
High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity
Autor:
Anna Kalota, Yang Feng, Daniel J. Powell, Rachel C. Lynn, Mathilde Poussin, Keith Schutsky, Dimiter S. Dimitrov
Publikováno v:
Leukemia
Acute myeloid leukemia (AML) is an aggressive malignancy, and development of new treatments to prolong remissions is warranted. Chimeric antigen receptor (CAR) T-cell therapies appear promising but on-target, off-tumor recognition of antigen in healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc8998555bf13db5083138814dbaee9
https://doi.org/10.1038/leu.2016.35
https://doi.org/10.1038/leu.2016.35
Publikováno v:
Vaccines, Vol 4, Iss 4, p 43 (2016)
Vaccines
Vaccines
Genomic destabilizers, such as radiation and chemotherapy, and epigenetic modifiers are used for the treatment of cancer due to their apoptotic effects on the aberrant cells. However, these therapies may also induce widespread changes within the immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f2075d5663104cbc5f09333fe0c17f
http://www.mdpi.com/2076-393X/4/4/43
http://www.mdpi.com/2076-393X/4/4/43
Publikováno v:
The Journal of Neuroscience. 32:1932-1941
Memories for emotionally arousing experiences are typically vivid and persistent. The recurrent, intrusive memories of traumatic events in post-traumatic stress disorder (PTSD) are an extreme example. Stress-responsive neurotransmitters released duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6043ff0b6d4902336b99e3da4866091
https://doi.org/10.1523/jneurosci.5231-11.2012
https://doi.org/10.1523/jneurosci.5231-11.2012
Publikováno v:
The Journal of Neuroscience. 31:14172-14181
Acute stress impairs the retrieval of hippocampus-dependent memory, and this effect is mimicked by exogenous administration of stress-responsive glucocorticoid hormones. It has been proposed that glucocorticoids affect memory by promoting the release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0641a596cb9205d50b7d38f8fda0e253
https://doi.org/10.1523/jneurosci.2122-11.2011
https://doi.org/10.1523/jneurosci.2122-11.2011
Autor:
Josephine S. Gnanandarajah, Daniel J. Powell, Keith Schutsky, Sondra Calhoun, Nicola J. Mason, M. Kazim Panjwani, Jenessa B. Smith, Laurence J.N. Cooper
Publikováno v:
Journal for Immunotherapy of Cancer
CD19 chimeric antigen receptor (CAR) T cell therapy has shown great promise in treating human hematological malignancies. However, the full potential of CAR technology has not been reached in solid malignancies and limitations exist in utilizing gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc89dcf45a217221bc256b759befa25a
https://doi.org/10.1186/2051-1426-3-s2-p123
https://doi.org/10.1186/2051-1426-3-s2-p123