Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Keith Saunders"'
Autor:
Sophie E. Roberts, Heather L. Martin, Danah Al-Qallaf, Anna A. Tang, Christian Tiede, Thembaninkosi G. Gaule, Albor Dobon-Alonso, Ross Overman, Sachin Shah, Hadrien Peyret, Keith Saunders, Robin Bon, Iain W. Manfield, Sandra M. Bell, George P. Lomonossoff, Valerie Speirs, Darren C. Tomlinson
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110461- (2024)
Summary: Monoclonal antibodies have revolutionized therapies, but non-immunoglobulin scaffolds are becoming compelling alternatives owing to their adaptability. Their ability to be labeled with imaging or cytotoxic compounds and to create multimeric
Externí odkaz:
https://doaj.org/article/afbbfa1f915d4d408b05c261d3880b47
Autor:
Houssam Attoui, Fauziah Mohd Jaafar, Baptiste Monsion, Bernard Klonjkowski, Elizabeth Reid, Petra C. Fay, Keith Saunders, George Lomonossoff, David Haig, Peter P. C. Mertens
Publikováno v:
Pathogens, Vol 12, Iss 4, p 602 (2023)
Bluetongue is an economically important disease of domesticated and wild ruminants caused by bluetongue virus (BTV). There are at least 36 different serotypes of BTV (the identity of which is determined by its outer-capsid protein VP2), most of which
Externí odkaz:
https://doaj.org/article/89919daa04cb4d46a3c5f3e62574414c
Autor:
Keith Saunders, Eva C. Thuenemann, Sachin N. Shah, Hadrien Peyret, Ruth Kristianingsih, Sergio G. Lopez, Jake Richardson, George P. Lomonossoff
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The production of designer-length tobacco mosaic virus (TMV) nanorods in plants has been problematic in terms of yields, particularly when modified coat protein subunits are incorporated. To address this, we have investigated the use of a replicating
Externí odkaz:
https://doaj.org/article/770666d1984648379319e5e8a008761a
Autor:
Emma L. Hesketh, Keith Saunders, Chloe Fisher, Joran Potze, John Stanley, George P. Lomonossoff, Neil A. Ranson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Geminiviruses are an important plant pathogen that causes large food crop losses globally. Here the authors describe a high resolution cryo-EM structure of the Ageratum yellow vein virus and reveal the molecular details of how a single capsid protein
Externí odkaz:
https://doaj.org/article/ca7202310ade47b18e8158c00d6cfcd3
Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes
Autor:
Petra C. Fay, Fauziah Mohd Jaafar, Carrie Batten, Houssam Attoui, Keith Saunders, George P. Lomonossoff, Elizabeth Reid, Daniel Horton, Sushila Maan, David Haig, Janet M. Daly, Peter P. C. Mertens
Publikováno v:
Viruses, Vol 13, Iss 8, p 1455 (2021)
Bluetongue (BT) is a severe and economically important disease of ruminants that is widely distributed around the world, caused by the bluetongue virus (BTV). More than 28 different BTV serotypes have been identified in serum neutralisation tests (SN
Externí odkaz:
https://doaj.org/article/0c1dbd879f3f45e182c65b56f03661fe
Autor:
Eva C. Thuenemann, Matthew J. Byrne, Hadrien Peyret, Keith Saunders, Roger Castells-Graells, Inmaculada Ferriol, Mattia Santoni, John F. C. Steele, Neil A. Ranson, Linda Avesani, Juan Jose Lopez-Moya, George P. Lomonossoff
Publikováno v:
Viruses, Vol 13, Iss 5, p 885 (2021)
The production of plant helical virus-like particles (VLPs) via plant-based expression has been problematic with previous studies suggesting that an RNA scaffold may be necessary for their efficient production. To examine this, we compared the accumu
Externí odkaz:
https://doaj.org/article/2ba02e7ef9e8407fa6b0d37317efde36
Publikováno v:
Viruses, Vol 12, Iss 11, p 1235 (2020)
Geminivirus particles, consisting of a pair of twinned isometric structures, have one of the most distinctive capsids in the virological world. Until recently, there was little information as to how these structures are generated. To address this, we
Externí odkaz:
https://doaj.org/article/ee587f6e5ee84ed3a07648c63ac9cd06
Autor:
Keith Saunders, George P. Lomonossoff
Publikováno v:
Frontiers in Plant Science, Vol 8 (2017)
We have utilized plant-based transient expression to produce tobacco mosaic virus (TMV)-based nano-rods of predetermined lengths. This is achieved by expressing RNAs containing the TMV origin of assembly sequence (OAS) and the sequence of the TMV coa
Externí odkaz:
https://doaj.org/article/680cf2ae176045b9b4fdbfa3d2a17de2
Publikováno v:
Virology. 577
We have developed methods for the templated synthesis of palladium nanowires (Pd NWs) within the central channel of tobacco mosaic virus (TMV) nanorods of various lengths. We show that uniform 4 nm diameter Pd NWs can be produced by selective growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac56248477955bc4951aa14affa04cd4
https://pubmed.ncbi.nlm.nih.gov/36384077
https://pubmed.ncbi.nlm.nih.gov/36384077
Publikováno v:
Journal of Molecular Biology. 434:167873
We have investigated whether the presence of the origin of assembly sequence (OAS) of tobacco mosaic virus (TMV) is necessary for the specific encapsidation of replicating viral RNA. To this end TMV coat protein was expressed from replicating RNA con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7781ee036f858cecf881585ff32944
https://doi.org/10.1016/j.jmb.2022.167873
https://doi.org/10.1016/j.jmb.2022.167873