Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Keith S. Bahjat"'
Autor:
Alejandro F. Alice, Gwen Kramer, Shelly Bambina, Keith S. Bahjat, Michael J. Gough, Marka R. Crittenden
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Gamma-delta (γδ) T cells express T cell receptors (TCR) that are preconfigured to recognize signs of pathogen infection. In primates, γδ T cells expressing the Vγ9Vδ2 TCR innately recognize (E)-4-hydroxy-3-methyl-but- 2-enyl pyrophosph
Externí odkaz:
https://doaj.org/article/3aa643bb4b9548359bcb1c52a0b143a9
Autor:
Benjamin Cottam, Kristina Young, Pippa Newell, Todd Crocenzi, Chet Hammill, Zeljka Jutric, Ronald F. Wolf, Paul D. Hansen, Matthew C. Solhjem, Yue-Yun To, Amy Greathouse, Garth Tormoen, Keith S. Bahjat, Michael J. Gough, Marka R. Crittenden
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
Background Preclinical studies have shown synergy between radiation therapy and immunotherapy. However, in almost all preclinical models, radiation is delivered in single doses or short courses of high doses (hypofractionated radiation). By contrast
Externí odkaz:
https://doaj.org/article/2403eb5742d0484c8d84f42cda596a9b
Autor:
Richard D. Schulick, Drew M. Pardoll, Thomas W. Dubensky, David N. Cook, Jill E. Slansky, Meredith L. Leong, Keith S. Bahjat, Martin A. Giedlin, Dirk G. Brockstedt, Sowmya Ravi, Christina Y. Chia, Lindsay S. Laird, Heather E. Allen, Ajay Jain, Kiyoshi Yoshimura
Improved immunization and ex vivo T-cell culture strategies can generate larger numbers and more potent tumor-specific effector cells than previously possible. Nonetheless, the capacity of these cells to eliminate established tumors is limited by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb7d48a9d38fbba96196cfc94730119
https://doi.org/10.1158/0008-5472.c.6494138
https://doi.org/10.1158/0008-5472.c.6494138
Autor:
Keith S. Bahjat, Alan J. Korman, Frances Rena Bahjat, Christina Milburn, Walter J. Urba, Brendan D. Curti, Richard K. Fuerstenberg, Michael D. Rynning, Shelly A. Bambina, Helena M. Hoen, Yoshinobu Koguchi
Treatment with ipilimumab improves overall survival (OS) in patients with metastatic melanoma. Because ipilimumab targets T lymphocytes and not the tumor itself, efficacy may be uniquely sensitive to immunomodulatory factors present at the time of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf81adbb03d29b4b3fd8e28d92b4ddf
https://doi.org/10.1158/0008-5472.c.6507456.v1
https://doi.org/10.1158/0008-5472.c.6507456.v1
Autor:
Keith S. Bahjat, Alan J. Korman, Frances Rena Bahjat, Christina Milburn, Walter J. Urba, Brendan D. Curti, Richard K. Fuerstenberg, Michael D. Rynning, Shelly A. Bambina, Helena M. Hoen, Yoshinobu Koguchi
Figure S1A. Kaplan-Meier plot of survival by CXCL11 group for gp100-treated melanoma patients Figure S1B. Kaplan-Meier plot of survival by CXCL11 group for ipilimumab-treated melanoma patients Figure S1C. Kaplan-Meier plot of survival by MICA group f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617bee7b85c9743127e92ce5514fe940
https://doi.org/10.1158/0008-5472.22408083.v1
https://doi.org/10.1158/0008-5472.22408083.v1
Autor:
Richard D. Schulick, Drew M. Pardoll, Thomas W. Dubensky, David N. Cook, Jill E. Slansky, Meredith L. Leong, Keith S. Bahjat, Martin A. Giedlin, Dirk G. Brockstedt, Sowmya Ravi, Christina Y. Chia, Lindsay S. Laird, Heather E. Allen, Ajay Jain, Kiyoshi Yoshimura
Supplementary Data 1-2 from Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated Listeria monocytogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6089e76f1d441452b70f9ee177a84f04
https://doi.org/10.1158/0008-5472.22364327.v1
https://doi.org/10.1158/0008-5472.22364327.v1
Autor:
Michael J. Gough, Marka R. Crittenden, Alejandro F Alice, Shelly Bambina, Keith S Bahjat, Gwen Kramer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports
Scientific Reports
Gamma-delta (γδ) T cells express T cell receptors (TCR) that are preconfigured to recognize signs of pathogen infection. In primates, γδ T cells expressing the Vγ9Vδ2 TCR innately recognize (E)-4-hydroxy-3-methyl-but- 2-enyl pyrophosphate (HMBP
Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy.
Autor:
Kristina H Young, Jason R Baird, Talicia Savage, Benjamin Cottam, David Friedman, Shelly Bambina, David J Messenheimer, Bernard Fox, Pippa Newell, Keith S Bahjat, Michael J Gough, Marka R Crittenden
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157164 (2016)
The anecdotal reports of promising results seen with immunotherapy and radiation in advanced malignancies have prompted several trials combining immunotherapy and radiation. However, the ideal timing of immunotherapy with radiation has not been clari
Externí odkaz:
https://doaj.org/article/2781218293ae4eadb113a4a1d59defb7
Autor:
Andrea Olga Andrea Olga Shorts, Aaron P. Yamniuk, Keith S. Bahjat, Radha Ramakrishnan, Gaëlle Martin, Sanjib Dutta, David A Critton, Hua Fang, Dibella Rose A, Kader Thiam, Lynne Campbell, Arathi Krishnakumar, Burce Ergel, Martin J. Corbett, Haibin Chen, Robert J. Johnston, Richard Y.-C. Huang, Alan J. Korman, Joseph M. Rizzo, Thomas Cayton, Zheng Yang, Michael Quigley, Jason Pinckney, Ying-Kai Wang, Ginger Rakestraw, Justine Ngo, Paul O. Sheppard, Linhui Julie Su, Andrew Rankin, Jim Holloway, Xiaodi Deng, Akbar Nayeem, Arvind Rajpal, Eric Boyer, Hadia Lemar, Alexander T. Kozhich
Publikováno v:
Nature. 574:565-570
Co-inhibitory immune receptors can contribute to T cell dysfunction in patients with cancer1,2. Blocking antibodies against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) partially reverse this effect and are
Autor:
Marka R Crittenden, Talicia Savage, Benjamin Cottam, Keith S Bahjat, William L Redmond, Shelly Bambina, Melissa Kasiewicz, Pippa Newell, Andrew M Jackson, Michael J Gough
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69527 (2013)
Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of systemic immunosuppression. We demonstrate that radiation therapy of tumors leads to a decline in myeloid cell numbers in the blood and a decrease in spleen
Externí odkaz:
https://doaj.org/article/f186f44cfd354180954eea7fe5da8f19