Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Keith S Bahjat"'
Autor:
Lauren Zebertavage, Shelly Bambina, Jessica Shugart, Alejandro Alice, Kyra D Zens, Peter Lauer, Bill Hanson, Michael J Gough, Marka R Crittenden, Keith S Bahjat
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209153 (2019)
Dysregulated signaling via the epidermal growth factor receptor (EGFR)-family is believed to contribute to the progression of a diverse array of cancers. The most common variant of EGFR is EGFRvIII, which results from a consistent and tumor-specific
Externí odkaz:
https://doaj.org/article/4c25820ef0e34565971f0f5e86283508
Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy.
Autor:
Kristina H Young, Jason R Baird, Talicia Savage, Benjamin Cottam, David Friedman, Shelly Bambina, David J Messenheimer, Bernard Fox, Pippa Newell, Keith S Bahjat, Michael J Gough, Marka R Crittenden
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157164 (2016)
The anecdotal reports of promising results seen with immunotherapy and radiation in advanced malignancies have prompted several trials combining immunotherapy and radiation. However, the ideal timing of immunotherapy with radiation has not been clari
Externí odkaz:
https://doaj.org/article/2781218293ae4eadb113a4a1d59defb7
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64878 (2013)
The ability of memory CD8+ T cells to rapidly proliferate and acquire cytolytic activity is critical for protective immunity against intracellular pathogens. The signals that control this recall response remain unclear. We show that CD40L production
Externí odkaz:
https://doaj.org/article/9e127a608daa483ca0a9e921e463531d
Autor:
Marka R Crittenden, Talicia Savage, Benjamin Cottam, Keith S Bahjat, William L Redmond, Shelly Bambina, Melissa Kasiewicz, Pippa Newell, Andrew M Jackson, Michael J Gough
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69527 (2013)
Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of systemic immunosuppression. We demonstrate that radiation therapy of tumors leads to a decline in myeloid cell numbers in the blood and a decrease in spleen
Externí odkaz:
https://doaj.org/article/f186f44cfd354180954eea7fe5da8f19
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11144 (2010)
Immunotherapeutic strategies to stimulate anti-tumor immunity are promising approaches for cancer treatment. A major barrier to their success is the immunosuppressive microenvironment of tumors, which inhibits the functions of endogenous dendritic ce
Externí odkaz:
https://doaj.org/article/46912c75a9b54ebc874d3c405e09a90d
Autor:
Keith S Bahjat, Nicole Meyer-Morse, Edward E Lemmens, Jessica A Shugart, Thomas W Dubensky, Dirk G Brockstedt, Daniel A Portnoy
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9, p e1000568 (2009)
Listeria monocytogenes is a facultative intracellular pathogen capable of inducing a robust cell-mediated immune response to sub-lethal infection. The capacity of L. monocytogenes to escape from the phagosome and enter the host cell cytosol is paramo
Externí odkaz:
https://doaj.org/article/24e54cb286f54a5a8a61c46bba2fe71d
Autor:
Richard D. Schulick, Drew M. Pardoll, Thomas W. Dubensky, David N. Cook, Jill E. Slansky, Meredith L. Leong, Keith S. Bahjat, Martin A. Giedlin, Dirk G. Brockstedt, Sowmya Ravi, Christina Y. Chia, Lindsay S. Laird, Heather E. Allen, Ajay Jain, Kiyoshi Yoshimura
Improved immunization and ex vivo T-cell culture strategies can generate larger numbers and more potent tumor-specific effector cells than previously possible. Nonetheless, the capacity of these cells to eliminate established tumors is limited by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb7d48a9d38fbba96196cfc94730119
https://doi.org/10.1158/0008-5472.c.6494138
https://doi.org/10.1158/0008-5472.c.6494138
Autor:
Keith S. Bahjat, Alan J. Korman, Frances Rena Bahjat, Christina Milburn, Walter J. Urba, Brendan D. Curti, Richard K. Fuerstenberg, Michael D. Rynning, Shelly A. Bambina, Helena M. Hoen, Yoshinobu Koguchi
Treatment with ipilimumab improves overall survival (OS) in patients with metastatic melanoma. Because ipilimumab targets T lymphocytes and not the tumor itself, efficacy may be uniquely sensitive to immunomodulatory factors present at the time of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf81adbb03d29b4b3fd8e28d92b4ddf
https://doi.org/10.1158/0008-5472.c.6507456.v1
https://doi.org/10.1158/0008-5472.c.6507456.v1
Autor:
Keith S. Bahjat, Alan J. Korman, Frances Rena Bahjat, Christina Milburn, Walter J. Urba, Brendan D. Curti, Richard K. Fuerstenberg, Michael D. Rynning, Shelly A. Bambina, Helena M. Hoen, Yoshinobu Koguchi
Figure S1A. Kaplan-Meier plot of survival by CXCL11 group for gp100-treated melanoma patients Figure S1B. Kaplan-Meier plot of survival by CXCL11 group for ipilimumab-treated melanoma patients Figure S1C. Kaplan-Meier plot of survival by MICA group f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617bee7b85c9743127e92ce5514fe940
https://doi.org/10.1158/0008-5472.22408083.v1
https://doi.org/10.1158/0008-5472.22408083.v1
Autor:
Richard D. Schulick, Drew M. Pardoll, Thomas W. Dubensky, David N. Cook, Jill E. Slansky, Meredith L. Leong, Keith S. Bahjat, Martin A. Giedlin, Dirk G. Brockstedt, Sowmya Ravi, Christina Y. Chia, Lindsay S. Laird, Heather E. Allen, Ajay Jain, Kiyoshi Yoshimura
Supplementary Data 1-2 from Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated Listeria monocytogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6089e76f1d441452b70f9ee177a84f04
https://doi.org/10.1158/0008-5472.22364327.v1
https://doi.org/10.1158/0008-5472.22364327.v1