Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Keith S, Dillman"'
Autor:
Sébastien L, Degorce, Rana, Anjum, Andrew, Bloecher, Rodrigo J, Carbajo, Keith S, Dillman, Lisa, Drew, Christopher T, Halsall, Eva M, Lenz, Nicola A, Lindsay, Michele F, Mayo, Jennifer H, Pink, Graeme R, Robb, Alan, Rosen, James S, Scott, Yafeng, Xue
Publikováno v:
Journal of medicinal chemistry. 62(21)
In this article, we report the discovery of a series of 5-azaquinazolines as selective IRAK4 inhibitors. From modestly potent quinazoline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8929c269d95a7fdb4b89ef21869d21c5
https://pubmed.ncbi.nlm.nih.gov/31622099
https://pubmed.ncbi.nlm.nih.gov/31622099
Autor:
James S, Scott, Sébastien L, Degorce, Rana, Anjum, Janet, Culshaw, Robert D M, Davies, Nichola L, Davies, Keith S, Dillman, James E, Dowling, Lisa, Drew, Andrew D, Ferguson, Sam D, Groombridge, Christopher T, Halsall, Julian A, Hudson, Scott, Lamont, Nicola A, Lindsay, Stacey K, Marden, Michele F, Mayo, J Elizabeth, Pease, David R, Perkins, Jennifer H, Pink, Graeme R, Robb, Alan, Rosen, Minhui, Shen, Claire, McWhirter, Dedong, Wu
Publikováno v:
Journal of medicinal chemistry. 60(24)
Herein we report the optimization of a series of pyrrolopyrimidine inhibitors of interleukin-1 receptor associated kinase 4 (IRAK4) using X-ray crystal structures and structure based design to identify and optimize our scaffold. Compound 28 demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0123c6a11a82f0bdcbd73931a51e9a3
https://pubmed.ncbi.nlm.nih.gov/29172502
https://pubmed.ncbi.nlm.nih.gov/29172502
Autor:
Samuel P. Simons, Mahmoud N. Mansour, Peter K. LeMotte, Frank S. Menniti, Paul A. Aeed, Shenping Liu, Dennis E. Danley, Jose R. Perez, Keith S. Dillman
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13309-13314
The phosphodiesterases (PDEs) are metal ion-dependent enzymes that regulate cellular signaling by metabolic inactivation of the ubiquitous second messengers cAMP and cGMP. In this role, the PDEs are involved in many biological and metabolic processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7ef653ebe4aad94541b21c57f49d5a
https://doi.org/10.1073/pnas.0708850105
https://doi.org/10.1073/pnas.0708850105
Publikováno v:
The Journal of Neuroscience. 21:5079-5088
Chronic activity blockade increases synaptic levels of NMDA receptor immunoreactivity in hippocampal neurons. We show here that blockade-induced synaptic NMDA receptors are functional and mediate enhanced excitotoxicity in response to synaptically re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518b62794de90a85e340b3417179a1b3
https://doi.org/10.1523/jneurosci.21-14-05079.2001
https://doi.org/10.1523/jneurosci.21-14-05079.2001
Autor:
Michael D. Forman, Keith S. Dillman, Frank S. Menniti, Kimberly F. Fennell, Jayvardhan Pandit
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(43)
We report the X-ray crystal structure of a phosphodiesterase (PDE) that includes both catalytic and regulatory domains. PDE2A (215–900) crystallized as a dimer in which each subunit had an extended organization of regulatory GAF-A and GAF-B and cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6445f2529073efe85f788601ada062a6
https://pubmed.ncbi.nlm.nih.gov/19828435
https://pubmed.ncbi.nlm.nih.gov/19828435