Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Keith Reeves"'
Autor:
Harikrishnan Balachandran, Kyle Kroll, Karen Terry, Cordelia Manickam, Rhianna Jones, Griffin Woolley, Tammy Hayes, Amanda J Martinot, Ankur Sharma, Mark Lewis, Stephanie Jost, R Keith Reeves
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012439 (2024)
Natural killer (NK) cells play a critical role in virus control. However, it has remained largely unclear whether NK cell mobilization in SARS-CoV-2 infections is beneficial or pathologic. To address this deficit, we employed a validated experimental
Externí odkaz:
https://doaj.org/article/6060b7066f3a4926857118d4855db1c9
Autor:
Cordelia Manickam, Amit A Upadhyay, Griffin Woolley, Kyle W Kroll, Karen Terry, Courtney A Broedlow, Nichole R Klatt, Steven E Bosinger, R Keith Reeves
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012223 (2024)
Natural killer-like B (NKB) cells are unique innate immune cells expressing both natural killer (NK) and B cell receptors. As first responders to infection, they secrete IL-18 to induce a critical cascade of innate and adaptive immune cell infiltrati
Externí odkaz:
https://doaj.org/article/66bb7e6cf16643e8817768d7427341ee
Autor:
Marina Tuyishime, Rachel L. Spreng, Brady Hueber, Junsuke Nohara, Derrick Goodman, Cliburn Chan, Richard Barfield, Whitney E. Beck, Shalini Jha, Stephanie Asdell, Kevin Wiehe, Max M. He, David Easterhoff, Haleigh E. Conley, Taylor Hoxie, Thaddeus Gurley, Caroline Jones, Nihar Deb Adhikary, Francois Villinger, Rasmi Thomas, Thomas N. Denny, Michael Anthony Moody, Georgia D. Tomaras, Justin Pollara, R. Keith Reeves, Guido Ferrari
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Rhesus macaques (RMs) are a common pre-clinical model used to test HIV vaccine efficacy and passive immunization strategies. Yet, it remains unclear to what extent the Fc-Fc receptor (FcR) interactions impacting antiviral activities of antibodies in
Externí odkaz:
https://doaj.org/article/b7b3507768fa4c4a8fd48081695cfafd
Autor:
Sho Sugawara, Brady Hueber, Griffin Woolley, Karen Terry, Kyle Kroll, Cordelia Manickam, Daniel R Ram, Lishomwa C Ndhlovu, Paul Goepfert, Stephanie Jost, R Keith Reeves
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011629 (2023)
Despite their importance, natural killer (NK) cell responses are frequently dysfunctional during human immunodeficiency virus-1 (HIV-1) and simian immunodeficiency virus (SIV) infections, even irrespective of antiretroviral therapies, with poorly und
Externí odkaz:
https://doaj.org/article/d835155fe136473c8794b99be669f303
Autor:
Kyle Kroll, R. Keith Reeves
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102044- (2023)
Summary: Identifying differential protein expression is routinely used to delineate natural killer (NK) cells from various sample cohorts. This protocol describes key steps for NK cell analysis: identifying human NK cells using flow gating, data expo
Externí odkaz:
https://doaj.org/article/d81a4ae987874470bf88fb2936485b4d
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Natural killer (NK) cells represent a critical defense against viral infections and cancers. NK cells require integration of activating and inhibitory NK cell receptors to detect target cells and the balance of these NK cell inputs defines the global
Externí odkaz:
https://doaj.org/article/d04d71c6e75746489ef59242681661a3
Autor:
Rhianna Jones, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, Daniel R. Ram, Cordelia Manickam, Valerie Varner, Nichole R. Klatt, R. Keith Reeves
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract HIV/SIV infections lead to massive loss of mucosal CD4 + T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of
Externí odkaz:
https://doaj.org/article/48692deb9b0a4041ad526778e7eb2847
Autor:
Ryan K. Cheu, Avid Mohammadi, Luca Schifanella, Courtney Broedlow, Connor B. Driscoll, Charlene J. Miller, R. Keith Reeves, Mark H. Yudin, Tiffany Hensley-McBain, Rupert Kaul, Nichole R. Klatt
Publikováno v:
Frontiers in Reproductive Health, Vol 4 (2022)
The role of neutrophils relative to vaginal dysbiosis is unclear. We hypothesize that bacterial vaginosis (BV)-associated bacteria may induce the activation and accumulation of mucosal neutrophils within the female reproductive tract (FRT), resulting
Externí odkaz:
https://doaj.org/article/67710ef1df794146bef44a57300be38c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Although antiretroviral therapy (ART) has drastically changed the lives of people living with human immunodeficiency virus-1 (HIV-1), long-term treatment has been associated with a vast array of comorbidities. Therefore, a cure for HIV-1 remains the
Externí odkaz:
https://doaj.org/article/a0baa23c423c4d9c81e0397673008536
Autor:
Nicolas Huot, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, Caroline Passaes, Rachel Legendre, Hugo Varet, Yoann Madec, Ulrike Sauermann, Christiane Stahl-Hennig, Jacob Nattermann, Asier Saez-Cirion, Roger Le Grand, R. Keith Reeves, Mirko Paiardini, Frank Kirchhoff, Beatrice Jacquelin, Michaela Müller-Trutwin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
NK cells control SIV infection in secondary lymphoid tissues in the natural host that typically doesn’t progress toward disease. Here the authors show that this control is associated with terminal NK cell differentiation and improved MHC-E-dependen
Externí odkaz:
https://doaj.org/article/7c09c41f3ce44f41931d8a99a69c119f