Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Keith R. Warner"'
Autor:
James B. Thomas, Scott P. Runyon, Jean-Michel Longpré, Angela M. Giddings, Philippe Sarret, Srinivas Olepu, Robert W. Wiethe, Brian P. Gilmour, Keith R. Warner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2060-2064
Compounds acting via the GPCR neurotensin receptor type 2 (NTS2) display analgesia in relevant preclinical models. The amide bond in nonpeptide NTS1 antagonists plays a central role in receptor recognition and molecular conformation. Using NTS2 FLIPR
Autor:
Angela M. Giddings, Keith R. Warner, Robert W. Wiethe, Philippe Sarret, James B. Thomas, Brian P. Gilmour, Srinivas Olepu, Jean-Michel Longpré, Scott P. Runyon, Sanju Narayanan, Danni L. Harris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:292-296
Compounds acting via the GPCR neurotensin receptor type 2 (NTS2) display analgesic effects in relevant animal models. Using a pharmacophore model based on known NT receptor nonpeptide compounds, we screened commercial databases to identify compounds
Autor:
Scott P. Runyon, Keith R. Warner, Louis Gendron, Angela M. Giddings, Philippe Sarret, James B. Thomas, Srinivas Olepu, Yanan Zhang, Jean-Michel Longpré, Brian P. Gilmour, Robert W. Wiethe
Publikováno v:
Journal of Medicinal Chemistry
Compounds acting via the neurotensin receptor type 2 (NTS2) are known to be active in animal models of acute and chronic pain. To identify novel NTS2 selective analgesics, we searched for NTS2 selective nonpeptide compounds using a FLIPR assay and id
Autor:
Scott P. Runyon, Jean-Michel Longpré, Yanan Zhang, Robert W. Wiethe, Angela M. Giddings, Philippe Sarret, Keith R. Warner, Srinivas Olepu, James B. Thomas, Brian P. Gilmour, Louis Gendron
Publikováno v:
Journal of Medicinal Chemistry
Compounds active at neurotensin receptors (NTS1 and NTS2) exert analgesic effects on different types of nociceptive modalities, including thermal, mechanical, and chemical stimuli. The NTS2 preferring peptide JMV-431 (2) and the NTS2 selective nonpep
Publikováno v:
SLAS Discovery. 18:1132-1137
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is an important regulator of ion transport and fluid secretion in humans. Mutations to CFTR cause cystic fibrosis, which is a common recessive genetic disorder in Caucasians. Invo
Autor:
Angela M. Giddings, Jean-Michel Longpré, Brian P. Gilmour, Ann M. Decker, Mélanie Vivancos, Scott P. Runyon, James B. Thomas, Alexandre Murza, Philippe Sarret, Élie Besserer-Offroy, Keith R. Warner, Robert W. Wiethe
Publikováno v:
ACS chemical neuroscience. 7(9)
Neurotensin receptor type 2 (NTS2) compounds display analgesic activity in animal pain models. We have identified the first high-affinity NTS2-selective antagonist (8) that is active in vivo. This study also revealed that the NTS2 FLIPR assay designa
Autor:
Vineetha Vasukuttan, Yanyan Zhang, Jeffery R. Deschamps, Scott P. Runyon, Rangan Maitra, James B. Thomas, Ann M. Decker, Sanju Narayanan, Katherine Bortoff, Keith R. Warner
Publikováno v:
Bioorganicmedicinal chemistry. 24(16)
The apelinergic system includes a series of endogenous peptides apelin, ELABELA/TODDLER and their 7-transmembrane G-protein coupled apelin receptor (APJ, AGTRL-1, APLNR). The APJ receptor is an attractive therapeutic target because of its involvement
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1438-1441
In a search for nonpeptide agonists for the neurotensin receptor (NTR1), we replaced the adamantyl amino acid moiety found in the antagonist SR48692 (1a) with leucine and related alpha-alkylamino acids found in peptide agonists. When tested in a calc
Autor:
Keith R. Warner
Publikováno v:
American journal of public health. 62(12)