Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Keith R. Kaderlik"'
Autor:
L. P. Mcdaniel, Candee H. Teitel, Keith R. Kaderlik, Nicholas P. Lang, Fred F. Kadlubar, Wolfgang W. Huber
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 376:115-122
The mutagenic heterocyclic aromatic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), is a pyrolysis product in cooked foods that has been shown to be a rat colon carcinogen and has been implicated in the etiology of human colon cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf81e3bd1a669a157825ea6b9a9813c
https://doi.org/10.1016/s0027-5107(97)00033-x
https://doi.org/10.1016/s0027-5107(97)00033-x
Autor:
Keith R. Kaderlik, Gerard J. Mulder, Joseph G. Shaddock, Daniel A. Casciano, Fred F. Kadlubar, Candee H. Teitel
Publikováno v:
Carcinogenesis. 15:1711-1716
The potent rat colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), unlike other food-borne heterocyclic amines, does not induce tumors in rat liver. This correlates with an extremely low level of PhIP-DNA adducts formed in this t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8848dc739063cc46fd64a7f0afb068c7
https://doi.org/10.1093/carcin/15.8.1711
https://doi.org/10.1093/carcin/15.8.1711
Autor:
Keith R. Kaderlik, Kenneth F. Ilett, Fred F. Kadlubar, Maria Daugaard-Jenson, Gerard J. Mulder, Candee H. Teitel, Rodney F. Minchin
Publikováno v:
Carcinogenesis. 15:1703-1709
The food-borne mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces tumors in colon of male rats and has been implicated in the etiology of human cancers, particularly colorectal cancer. This study was conducted to examine: (1) the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e099aebfd1bfa0275b60c961ab4597d9
https://doi.org/10.1093/carcin/15.8.1703
https://doi.org/10.1093/carcin/15.8.1703
Publikováno v:
Carcinogenesis. 14:2143-2147
4,4'-Methylenebis(2-chloroaniline) (MOCA) has considerable human occupational exposure and it induces urinary bladder tumors in the dog, a species that has been often used as a model for aromatic amine-induced urinary bladder carcinogenesis in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10856a603efdb5c7769315d554cf4f03
https://doi.org/10.1093/carcin/14.10.2143
https://doi.org/10.1093/carcin/14.10.2143
Publikováno v:
Environmental Health Perspectives
The metabolic pathways associated with carcinogenic aromatic amines in humans provide an excellent example of polymorphisms that appear to be relevant to human carcinogenesis. In this regard, the N-acetylation of arylamines and the O-acetylation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b884a7a8b2fa84ca9562d6a47e36618c
https://doi.org/10.1289/ehp.929869
https://doi.org/10.1289/ehp.929869
Autor:
Fred F. Kadlubar, Jackson O. Lay, Dwight W. Miller, Robert J. Turesky, Dongxin Lin, Keith R. Kaderlik
Publikováno v:
Chemical Research in Toxicology. 5:691-697
The covalent binding of the N-acetoxy-, N-hydroxy-, and nitro derivatives of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to 2'-deoxyribonucleosides or DNA was investigated in vitro and in vivo. N-Acetoxy-PhIP reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bc95f3451e8c932b62809cf2c84ca3
https://doi.org/10.1021/tx00029a016
https://doi.org/10.1021/tx00029a016
Autor:
Brian F. Coles, Kenneth F. Ilett, Candee H. Teitel, Joseph G. Shaddock, Wolfgang W. Huber, Daniel A. Casciano, Keith R. Kaderlik, Roberta S. King, Frederick W. Wiese, Gerard J. Mulder, Fred F. Kadlubar
Publikováno v:
Environmental and molecular mutagenesis. 44(4)
Coffee drinking has been associated with reduced incidence of colorectal cancer, possibly via chemoprotection/modification of the metabolism of dietary heterocyclic amine carcinogens such as 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bb392c856af3b3a6cdde68c89fdb49
https://pubmed.ncbi.nlm.nih.gov/15468054
https://pubmed.ncbi.nlm.nih.gov/15468054
Autor:
Keith R. Kaderlik, Fred F. Kadlubar
Publikováno v:
Pharmacogenetics.
Metabolic polymorphisms have long been recognized as important determinants of carcinogen susceptibility and recent efforts have shown that interindividual differences in specific cytochromes P450, acetyltransferases, sulfotransferases and glutathion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7459df975bd4005fcedd561ab473eee7
https://pubmed.ncbi.nlm.nih.gov/7581479
https://pubmed.ncbi.nlm.nih.gov/7581479
Autor:
Keith R. Kaderlik, Gerard J. Mulder, Fred F. Kadlubar, Nicholas P. Lang, M P Chiarelli, Robert J. Turesky, C. H. Teitel
Publikováno v:
Carcinogenesis. 15(8)
The food-borne carcinogenic and mutagenic heterocyclic aromatic amines undergo bioactivation to the corresponding N-hydroxy (OH)-arylamines and the subsequent N-glucuronidation of these metabolites is regarded as an important detoxification reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e046bb55daa306bfbb747309063826e
https://pubmed.ncbi.nlm.nih.gov/8055651
https://pubmed.ncbi.nlm.nih.gov/8055651
Autor:
Wolfgang W. Huber, Candee H. Teitel, Brian F. Coles, Roberta S. King, Frederick W. Wiese, Keith R. Kaderlik, Daniel A. Casciano, Joseph G. Shaddock, Gerard J. Mulder, Kenneth F. Ilett, Fred F. Kadlubar
Publikováno v:
Environmental & Molecular Mutagenesis; Sep2004, Vol. 44 Issue 4, p265-276, 12p