Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Keith R. Brunt"'
Autor:
Julie K.K. Vishram-Nielsen, MD, PhD, Fernando Luis Scolari, MD, PhD, Chun-Po Steve Fan, PhD, Yas Moayedi, MD, Heather J. Ross, MD, MHSc, Cedric Manlhiot, PhD, Melissa A. Allwood, MD, PhD, Ana Carolina Alba, MD, PhD, Keith R. Brunt, PhD, Jeremy A. Simpson, PhD, Filio Billia, MD, PhD
Publikováno v:
CJC Open, Vol 6, Iss 5, Pp 745-754 (2024)
Background: Diaphragm atrophy can contribute to dyspnea in patients with heart failure (HF) with its link to central neurohormonal overactivation. HF medications that cross the blood-brain barrier could act centrally and improve respiratory function,
Externí odkaz:
https://doaj.org/article/833a36761fe34a46a519f4e099cc39aa
Autor:
Jade P. Marrow, Razan Alshamali, Brittany A. Edgett, Melissa A. Allwood, Kyla L. S. Cochrane, Sara Al-Sabbag, Anmar Ayoub, Kjetil Ask, Gregory M. T. Hare, Keith R. Brunt, Jeremy A. Simpson
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Erythropoietin (EPO) exerts non-canonical roles beyond erythropoiesis that are developmentally, structurally, and physiologically relevant for the heart as a paracrine factor. The role for paracrine EPO signalling and cellular crosstalk in the adult
Externí odkaz:
https://doaj.org/article/6990942d25af46f7b4676d92858673c8
Autor:
Merry L. Lindsey, Keith R. Brunt, Petra Kleinbongard, Jason R. Carter, Crystal M. Ripplinger, Zamaneh Kassiri, Kara Hansell Keehan, Amanda J. LeBlanc, Jonathan A. Kirk
Publikováno v:
Physiological Reports, Vol 12, Iss 5, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/a7f373ce99b647f0b7a1df3c43d92000
Autor:
Chenxuan Wang, Barbora Hucik, Ousseynou Sarr, Liam H. Brown, Kyle R.D. Wells, Keith R. Brunt, Manabu T. Nakamura, Ewa Harasim-Symbor, Adrian Chabowski, David M. Mutch
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100376- (2023)
The Δ-6 desaturase (D6D) enzyme is not only critical for the synthesis of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from α-linolenic acid (ALA), but recent evidence suggests that it also plays a role in adipocyte lipid metabolism a
Externí odkaz:
https://doaj.org/article/03285ef0270040c3b186ceb9e6e46e07
Autor:
Shreya Sarkar, Jeffrey MacLeod, Ansar Hassan, Keith R. Brunt, Krisan Palmer, Jean-François Légaré
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Frail cardiac surgery patients have an increased risk of worse postoperative outcomes. The purpose of this study was to evaluate the implementation of a novel Telehealth Home monitoring Enhanced-Frailty And Cardiac Surgery (THE-FA
Externí odkaz:
https://doaj.org/article/1640d6d949354a729bca22d88dd19bdf
Autor:
Ryan Buyting, MSc, Sarah Melville, BSc (Hons), CRA, Hanif Chatur, MD, CCFP(EM), Christopher W. White, MD, PhD, FRCSC, Jean-François Légaré, MD, FRCSC, Sohrab Lutchmedial, MD, FRCPC, Keith R. Brunt, PhD
Publikováno v:
CJC Open, Vol 4, Iss 2, Pp 133-147 (2022)
Canada is a wealthy nation with a geographically diverse population, seeking health innovations to better serve patients in accordance with the Canada Health Act. In this country, population and geography converge with social determinants, policy, pr
Externí odkaz:
https://doaj.org/article/414d8d30500f4c38af05055eafb9714b
Autor:
Shreya Sarkar, PhD, Jeffrey B. MacLeod, BSc, Ansar Hassan, MD, PhD, Daniel J. Dutton, PhD, Keith R. Brunt, PhD, Jean-François Légaré, MD, PhD
Publikováno v:
JTCVS Open, Vol 8, Iss , Pp 491-502 (2021)
Background: Globally, an increasing number of vulnerable or frail patients are undergoing cardiac surgery. However, large-scale frailty data are often limited by the need for time-consuming frailty assessments. This study aimed to (1) create a retros
Externí odkaz:
https://doaj.org/article/9d5160a61adf40d984a357b7818c7ac8
Autor:
Leslie M. Ogilvie, Brittany A. Edgett, Simon Gray, Sally Al-Mufty, Jason S. Huber, Keith R. Brunt, Jeremy A. Simpson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cardiovascular and respiratory systems are anatomically and functionally linked; inspiration produces negative intrathoracic pressures that act on the heart and alter cardiac function. Inspiratory pressures increase with heart failure and ca
Externí odkaz:
https://doaj.org/article/f81faecfe49a4d2abbd96c1e0fd01c05
Publikováno v:
Physiological Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Limited data exist regarding the impact of an acute bout of exercise with varying intensities on irisin levels in the youth of different obesity statuses. The objectives were to (1) compare an acute bout of moderate continuous intensity (MCI
Externí odkaz:
https://doaj.org/article/576ef203cd9d42aa88919b29acfc8b88
Autor:
Christie M. Aguiar, Kareem Gawdat, Stephanie Legere, Jean Marshall, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil, Mathieu Castonguay, Keith R. Brunt, Jean-Francois Legare
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background The objectives of the study were to characterize and quantify cellular inflammation and structural remodeling of human atria and correlate findings with molecular markers of inflammation and patient surrogate outcome. Methods Volu
Externí odkaz:
https://doaj.org/article/9c829a9be3d04259b8e79b3e14aaf0df