Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Keith R. Bley"'
Autor:
J. Vaigunda Ragavendran, Petra Schweinhardt, Mark A. Ware, André Laferrière, Terence J. Coderre, Wiebke Gandhi, Gary J. Bennett, Keith R. Bley
Publikováno v:
Pain. 157(10)
This double-blind randomized controlled study was designed to evaluate the analgesic effects of topical treatments with clonidine (CLON) and pentoxifylline (PTX) tested alone or as low- and high-dose combinations in a human experimental model of pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f49a9c78e6618824aa9b201ef6eec9a
https://pubmed.ncbi.nlm.nih.gov/27385502
https://pubmed.ncbi.nlm.nih.gov/27385502
Publikováno v:
British Journal of Pharmacology. 149:110-120
Background and purpose: The current study examined the utility of the recently described prostacyclin (prostanoid IP) receptor antagonist RO1138452 (2-(4-(4-isopropoxybenzyl)-phenylamino) imidazoline) as a tool for classifying prostanoid receptors. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfb77d3c84a67cc5fbdd8c229b04c58e
https://doi.org/10.1038/sj.bjp.0706841
https://doi.org/10.1038/sj.bjp.0706841
Autor:
Keith R. Bley, Steven Smith, Don V Daniels, Anthony P.D.W. Ford, Dinesh Srinivasan, Mary-Frances Jett, Joel R Gever, Counde O'yang, Anindya Bhattacharya, Alam Jahangir
Publikováno v:
British Journal of Pharmacology. 147:335-345
Prostacyclin (PGI2) possesses various physiological functions, including modulation of nociception, inflammation and cardiovascular activity. Elucidation of these functions has been hampered by the absence of selective IP receptor antagonists. Two st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaea22c51d61f2c0898fbbcf5673aad7
https://doi.org/10.1038/sj.bjp.0706554
https://doi.org/10.1038/sj.bjp.0706554
Autor:
Keith R Bley
Publikováno v:
Expert Opinion on Investigational Drugs. 13:1445-1456
Capsaicin and other naturally occurring pungent molecules have been used for centuries as topical analgesics and rubefactants to treat a variety of chronically painful conditions. Recently, instillations of high-concentration capsaicin and resinifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20d43fc5dcecf185273cf10b3a66625
https://doi.org/10.1517/13543784.13.11.1445
https://doi.org/10.1517/13543784.13.11.1445
Autor:
Andrew P. Mizisin, Keith R. Bley, Wendye R. Robbins, Thorsten von Stein, Nigel A. Calcutt, Annika B. Malmberg
Publikováno v:
Pain. 111:360-367
Capsaicin-containing plant extracts have been used as topical treatments for a variety of pain syndromes for many centuries. Current products containing capsaicin in low concentrations (usually 0.025–0.075% w/w) have shown efficacy against a variet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282490ecc55c21f47741bfaf57f25164
https://doi.org/10.1016/j.pain.2004.07.017
https://doi.org/10.1016/j.pain.2004.07.017
Autor:
Mary Frances Jett, David J. Chang, Rick Salazar, Robin D. Clark, Thomas Chang, Keith R. Bley, Alam Jahangir, Daniel L. Severance, Steven Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1053-1056
On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl]amine] had analgesic activity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9d9237d8c606321b16b422f801b4207
https://doi.org/10.1016/j.bmcl.2003.10.070
https://doi.org/10.1016/j.bmcl.2003.10.070
Autor:
Imelda Omana-Zapata, Keith R. Bley
Publikováno v:
Brain Research. 904:85-92
Prostanoids sensitize sensory afferents during inflammation. However, their role in neuropathic pain is still unclear. We analyzed the actions of prostanoids, non-selective (indomethacin) or selective (celecoxib and NS-398) cyclooxygenase-2 (COX or C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c3d46fe935106af9c6e54228b821d1
https://doi.org/10.1016/s0006-8993(01)02486-6
https://doi.org/10.1016/s0006-8993(01)02486-6
Publikováno v:
British Journal of Pharmacology. 124:513-523
1. Prostanoid receptor-mediated sensitization, or excitation, of sensory nerve fibres contributes to the generation of hyperalgesia. To characterize the prostanoid receptors present on sensory neurones, biochemical assays were performed on primary cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2653ffde9b61b715abfcf3ede62c1a92
https://doi.org/10.1038/sj.bjp.0701853
https://doi.org/10.1038/sj.bjp.0701853
Publikováno v:
Trends in Pharmacological Sciences. 19:141-147
Prostanoid receptor-mediated sensitization of sensory nerve fibres is a key contributor to the generation of hyperalgesia. It is generally thought that prostaglandin (PG) E2 is the principal pro-inflammatory prostanoid. Consequently, prostanoid EP re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182fa35e09acb01c7fce0517f2b20261
https://doi.org/10.1016/s0165-6147(98)01185-7
https://doi.org/10.1016/s0165-6147(98)01185-7
Autor:
Michael Patrick Dillon, Richard M. Eglen, Joseph M. Muchowski, Robin D. Clark, Keith R. Bley, Chi-Ho Lee, Erik H. F. Wong, Douglas W. Bonhaus, K.K. Weinhardt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1853-1856
The enantiomers of the indolyl-2-oxoacetamide 5 were found to have 5-HT3 receptor partial agonist activity with (R)-5 having higher potency than (S)-5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a023dfc97e2042d7af0c58d65758382d
https://doi.org/10.1016/0960-894x(95)00308-g
https://doi.org/10.1016/0960-894x(95)00308-g