Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Keith R. Willison"'
Autor:
Vanessa Ho, Jonathan R. Baker, Keith R. Willison, Peter J. Barnes, Louise E. Donnelly, David R. Klug
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Expression levels of microRNAs (miRNAs) in single cells are low and conventional miRNA detection methods require amplification that can be complex, time-consuming, costly and may bias results. Single cell microfluidic platforms have been dev
Externí odkaz:
https://doaj.org/article/cdfa501ad3b04f55a4ee6bf9f99f19fc
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The multi-subunit chaperonin containing TCP-1 (CCT) is an essential molecular chaperone that functions in the folding of key cellular proteins. This paper reviews the interactome of the eukaryotic chaperonin CCT and its primary clients, the ubiquitou
Externí odkaz:
https://doaj.org/article/519e1cecb56344f58289487b9fbae055
Autor:
Bogachan Tahirbegi, Alastair J. Magness, Maria Elena Piersimoni, Xiangyu Teng, James Hooper, Yuan Guo, Thomas Knöpfel, Keith R. Willison, David R. Klug, Liming Ying
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Aggregation kinetics of proteins and peptides have been studied extensively due to their significance in many human diseases, including neurodegenerative disorders, and the roles they play in some key physiological processes. However, most of these s
Externí odkaz:
https://doaj.org/article/75ea4c38a6e541a4b5653121b314c1b0
Autor:
Liming Ying, Keith R. Willison, Thomas Knöpfel, Maria Elena Piersimoni, Bogachan Tahirbegi, Alastair J. Magness, David R. Klug
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Aggregates of amyloid-β (Aβ) are characteristic of Alzheimer’s disease, but there is no consensus as to either the nature of the toxic molecular complex or the mechanism by which toxic aggregates are produced. We report on a novel feature of amyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c10875631aed05269199de3bd7698e
http://link.springer.com/article/10.1038/s41598-020-66373-3
http://link.springer.com/article/10.1038/s41598-020-66373-3
Publikováno v:
BMB Reports, Vol 45, Iss 4, Pp 233-238 (2012)
We present a top down separation platform for yeast ribosomalproteins using affinity chromatography and capillary electrophoresiswhich is designed to allow deposition of proteins ontoa substrate. FLAG tagged ribosomes were affinity purified, andrRNA
Externí odkaz:
https://doaj.org/article/d303b64ff1f14404be68187dc4bafdd3
Publikováno v:
Chemphyschem : a European journal of chemical physics and physical chemistry. 22(23)
The interaction between α-synuclein (αSyn) and Cu2+ has been suggested to be closely linked to brain copper homeostasis. Disruption of copper levels could induce misfolding and aggregation of αSyn, and thus contribute to the progression of Parkins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83ef4360ad372c888fadec80dc15882
https://pubmed.ncbi.nlm.nih.gov/34779565
https://pubmed.ncbi.nlm.nih.gov/34779565
Autor:
Daniel Muthas, John Simpson, Linda Yrlid, Samantha Peel, Claus Bendtsen, Keith R. Willison, Suhuur Osman, David R. Klug
The cellular thermal shift assay (CETSA) has been used extensively since its introduction to study drug-target engagement within both live cells and cellular lysate. This has proven to be a useful tool in early stage drug discovery and is used to stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5bff7fd1921e710ba23b6a67d2ae5f
http://hdl.handle.net/10044/1/92554
http://hdl.handle.net/10044/1/92554
Autor:
David R. Klug, Peter J. Barnes, Vanessa Ho, Louise E. Donnelly, Keith R. Willison, Jonathan R. Baker
Publikováno v:
Airway cell biology and immunopathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f04ff11fa32ad4e49441c36601505cf
https://doi.org/10.1183/13993003.congress-2021.oa1365
https://doi.org/10.1183/13993003.congress-2021.oa1365
Autor:
Xiaoyan Lin, Jake Baum, Joshua B. Edel, Aleksandar P. Ivanov, Keith R. Willison, Ren Ren, Xiaoyi Wang, Mark D. Wilkinson
Publikováno v:
Chemical Science
Actin is a key protein in the dynamic processes within the eukaryotic cell. To date, methods exploring the molecular state of actin are limited to insights gained from structural approaches, providing a snapshot of protein folding, or methods that re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9accd8daa08afdf80ad4151ac91efa
http://hdl.handle.net/10044/1/82569
http://hdl.handle.net/10044/1/82569
Autor:
Mark D. Wilkinson, Keith R. Willison, Ren Ren, Xiaoyi Wang, Jake Baum, Joshua B. Edel, Xiaoyan Lin, Aleksandar P. Ivanov
Publikováno v:
Chemical Science
Actin is a key protein in the dynamic processes within the eukaryotic cell. To date, methods exploring the molecular state of actin are limited to insights gained from structural approaches, providing a snapshot of protein folding, or methods that re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d5fa3ad8c72b2e43b2c6a251a0dacc