Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Keith R Fowke"'
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007429 (2019)
HIV causes several forms of immune dysfunction that need to be addressed in a functional cure for HIV. Immune exhaustion describes a dysfunctional phenotype caused by chronic cellular activation. Lymphocyte activation gene-3 (LAG3) is one of several
Externí odkaz:
https://doaj.org/article/d6ecdd821f1649c586564fe869f5902b
Autor:
Kristi Loeb, Kieran A. Milner, Candice Lemaille, Brielle Martens, Derek Stein, Julie Lajoie, Souradet Y. Shaw, Anne W. Rimoin, Placide Mbala-Kingebeni, Nicole A. Hoff, Ryan S. Noyce, Keith R. Fowke, Joshua Kimani, Lyle McKinnon, Jason Kindrachuk
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 9, Pp 1944-1947 (2024)
We identified a cluster of mpox exposures among key populations in Kenya through retrospective serologic screening. We identified strong seropositivity among sex workers and gay, bisexual, and other men who have sex with men. These findings demonstra
Externí odkaz:
https://doaj.org/article/5b452ec95e4a41e6b9d57c76585c4b84
Autor:
Jocelyn M Wessels, Julie Lajoie, Danielle Vitali, Kenneth Omollo, Joshua Kimani, Julius Oyugi, Juliana Cheruiyot, Makubo Kimani, John N Mungai, Maureen Akolo, Jennifer C Stearns, Michael G Surette, Keith R Fowke, Charu Kaushic
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187612 (2017)
To compare the vaginal microbiota of women engaged in high-risk sexual behaviour (sex work) with women who are not engaged in high-risk sexual behaviour. Diverse vaginal microbiota, low in Lactobacillus species, like those in bacterial vaginosis (BV)
Externí odkaz:
https://doaj.org/article/7140c1859693432883f31b6d2b6c6389
Autor:
Frideborg Bradley, Alexandra Stern, Mathias Franzén Boger, Zaynab Mousavian, Olga Dethlefsen, Vilde Kaldhusdal, Julie Lajoie, Kenneth Omollo, Sofia Bergström, Anna Månberg, Peter Nilsson, Joshua Kimani, Adam D. Burgener, Annelie Tjernlund, Christopher Sundling, Keith R. Fowke, Kristina Broliden
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundThe cervicovaginal epithelial barrier is crucial for defending the female reproductive tract against sexually transmitted infections. Hormones, specifically estradiol and progesterone, along with their respective receptor expressions, play
Externí odkaz:
https://doaj.org/article/831fc87130c1463bb848812891560e77
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002838 (2012)
Natural killer T cells (NKT cells) represent a subset of T lymphocytes that express natural killer (NK) cell surface markers. A subset of NKT cells, termed invariant NKT cells (iNKT), express a highly restricted T cell receptor (TCR) and respond to C
Externí odkaz:
https://doaj.org/article/366e5430eafb43a3aa6c622cdd44c2bf
Autor:
John J Schellenberg, Tim J Dumonceaux, Janet E Hill, Joshua Kimani, Walter Jaoko, Charles Wachihi, Jane Njeri Mungai, Margo Lane, Keith R Fowke, T Blake Ball, Francis A Plummer
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41217 (2012)
The common but poorly understood condition known as bacterial vaginosis (BV) increases vulnerability to HIV infection and is associated with the absence of H(2)O(2)-producing Lactobacillus. Vaginal lactic acid bacteria (LAB) produce anti-HIV factors
Externí odkaz:
https://doaj.org/article/b62c185b830a41878330cbabfeee6cd9
Reduced cellular susceptibility to in vitro HIV infection is associated with CD4+ T cell quiescence.
Autor:
Catherine M Card, W John Rutherford, Suzie Ramdahin, Xiaojian Yao, Makobu Kimani, Charles Wachihi, Joshua Kimani, Francis A Plummer, T Blake Ball, Keith R Fowke
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45911 (2012)
HIV preferentially establishes productive infection in activated CD4+ T cells. Since proportions of activated CD4+ T cells vary between individuals, this study aimed to determine if individuals with a greater proportion of activated CD4+ T cells woul
Externí odkaz:
https://doaj.org/article/c3d130bfec6b499f9bc2aad795676755
Autor:
Valérie Thibodeau, Julie Lajoie, Annie-Claude Labbé, Marcel D Zannou, Keith R Fowke, Michel Alary, Johanne Poudrier, Michel Roger
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25185 (2011)
Most HIV infections are transmitted across mucosal epithelium. Understanding the role of innate and specific mucosal immunity in susceptibility or protection against HIV infection, as well as the effect of HIV infection on mucosal immunity, are of fu
Externí odkaz:
https://doaj.org/article/e65a574a9a0c4a42a9547b437628e0b0
Autor:
Lyle R McKinnon, Xiaojuan Mao, Joshua Kimani, Charles Wachihi, Christina Semeniuk, Mark Mendoza, Binhua Liang, Ma Luo, Keith R Fowke, Francis A Plummer, T Blake Ball
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6965 (2009)
CD8+ T cell responses are often detected at large magnitudes in HIV-infected subjects, and eliciting these responses is the central aim of many HIV-1 vaccine strategies. Population differences in CD8+ T cell epitope specificity will need to be unders
Externí odkaz:
https://doaj.org/article/534621f423824b9aa83622eccad609f7
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Invariant Natural Killer T (iNKT) cells undergo immune exhaustion during chronic activation caused by cancer and viral infections, such as HIV. Exhaustion is marked by cell dysfunction and increased expression of immune checkpoint proteins p
Externí odkaz:
https://doaj.org/article/833a43f6784741d4becad9e703bb15fa