Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Keith R Brunt"'
Autor:
Amy Brown, Intekhab Hossain, Lester J Perez, Carine Nzirorera, Kathleen Tozer, Kenneth D'Souza, Purvi C Trivedi, Christie Aguiar, Alexandra M Yip, Jennifer Shea, Keith R Brunt, Jean-Francois Legare, Ansar Hassan, Thomas Pulinilkunnil, Petra C Kienesberger
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189402 (2017)
Lysophosphatidic acid (LPA) receptor signaling has been implicated in cardiovascular and obesity-related metabolic disease. However, the distribution and regulation of LPA receptors in the myocardium and adipose tissue remain unclear.This study aimed
Externí odkaz:
https://doaj.org/article/45e0e150667b41e18bc7376440a54e01
Autor:
Blair MacLeod, Chenxuan Wang, Liam H. Brown, Emma Borkowski, Manabu T. Nakamura, Kyle RD. Wells, Keith R. Brunt, Ewa Harasim-Symbor, Adrian Chabowski, David M. Mutch
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 10, Pp 100642- (2024)
The production of the omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from alpha-linolenic acid (ALA) relies on the delta-6 desaturase (D6D) enzyme encoded by the Fads2 gene. Whil
Externí odkaz:
https://doaj.org/article/7d06e0fec0d945ba98cf666b178b776f
Autor:
Julie K.K. Vishram-Nielsen, MD, PhD, Fernando Luis Scolari, MD, PhD, Chun-Po Steve Fan, PhD, Yas Moayedi, MD, Heather J. Ross, MD, MHSc, Cedric Manlhiot, PhD, Melissa A. Allwood, MD, PhD, Ana Carolina Alba, MD, PhD, Keith R. Brunt, PhD, Jeremy A. Simpson, PhD, Filio Billia, MD, PhD
Publikováno v:
CJC Open, Vol 6, Iss 5, Pp 745-754 (2024)
Background: Diaphragm atrophy can contribute to dyspnea in patients with heart failure (HF) with its link to central neurohormonal overactivation. HF medications that cross the blood-brain barrier could act centrally and improve respiratory function,
Externí odkaz:
https://doaj.org/article/833a36761fe34a46a519f4e099cc39aa
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Drug repurposing has gained significant interest in recent years due to the high costs associated with de novo drug development; however, comprehensive pharmacological information is needed for the translation of pre‐existing drugs across
Externí odkaz:
https://doaj.org/article/0df18e265eb7434b91edf3e13c5724f2
Autor:
Jade P. Marrow, Razan Alshamali, Brittany A. Edgett, Melissa A. Allwood, Kyla L. S. Cochrane, Sara Al-Sabbag, Anmar Ayoub, Kjetil Ask, Gregory M. T. Hare, Keith R. Brunt, Jeremy A. Simpson
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Erythropoietin (EPO) exerts non-canonical roles beyond erythropoiesis that are developmentally, structurally, and physiologically relevant for the heart as a paracrine factor. The role for paracrine EPO signalling and cellular crosstalk in the adult
Externí odkaz:
https://doaj.org/article/6990942d25af46f7b4676d92858673c8
Autor:
Victoria L. Nelson, Ashley L. Eadie, Lester Perez, Malav Madhu, Mathew Platt, Angella Mercer, Thomas Pulinilkunnil, Petra Kienesberger, Jeremy A. Simpson, Keith R. Brunt
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1299 (2024)
Myocardial infarction and reperfusion constitute a complex injury consisting of many distinct molecular stress patterns that influence cardiomyocyte survival and adaptation. Cell signalling, which is essential to cardiac development, also presents po
Externí odkaz:
https://doaj.org/article/b0d501f4bb1c4babaebb502100a53e50
Autor:
Merry L. Lindsey, Keith R. Brunt, Petra Kleinbongard, Jason R. Carter, Crystal M. Ripplinger, Zamaneh Kassiri, Kara Hansell Keehan, Amanda J. LeBlanc, Jonathan A. Kirk
Publikováno v:
Physiological Reports, Vol 12, Iss 5, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/a7f373ce99b647f0b7a1df3c43d92000
Autor:
Shreya Sarkar, Jeffrey MacLeod, Ansar Hassan, Keith R. Brunt, Krisan Palmer, Jean-François Légaré
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Frail cardiac surgery patients have an increased risk of worse postoperative outcomes. The purpose of this study was to evaluate the implementation of a novel Telehealth Home monitoring Enhanced-Frailty And Cardiac Surgery (THE-FA
Externí odkaz:
https://doaj.org/article/1640d6d949354a729bca22d88dd19bdf
Autor:
Chenxuan Wang, Barbora Hucik, Ousseynou Sarr, Liam H. Brown, Kyle R.D. Wells, Keith R. Brunt, Manabu T. Nakamura, Ewa Harasim-Symbor, Adrian Chabowski, David M. Mutch
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100376- (2023)
The Δ-6 desaturase (D6D) enzyme is not only critical for the synthesis of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from α-linolenic acid (ALA), but recent evidence suggests that it also plays a role in adipocyte lipid metabolism a
Externí odkaz:
https://doaj.org/article/03285ef0270040c3b186ceb9e6e46e07
Autor:
Ryan Buyting, MSc, Sarah Melville, BSc (Hons), CRA, Hanif Chatur, MD, CCFP(EM), Christopher W. White, MD, PhD, FRCSC, Jean-François Légaré, MD, FRCSC, Sohrab Lutchmedial, MD, FRCPC, Keith R. Brunt, PhD
Publikováno v:
CJC Open, Vol 4, Iss 2, Pp 133-147 (2022)
Canada is a wealthy nation with a geographically diverse population, seeking health innovations to better serve patients in accordance with the Canada Health Act. In this country, population and geography converge with social determinants, policy, pr
Externí odkaz:
https://doaj.org/article/414d8d30500f4c38af05055eafb9714b