Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Keith R, Yamamoto"'
Autor:
Keith R. Yamamoto
Publikováno v:
Science. 379:1308-1308
Autor:
Masako Asahina, Keith R. Yamamoto, Kirk T. Ehmsen, Matthew T. Knuesel, Haruna Aridomi, Delsy M. Martinez
Publikováno v:
Nucleic acids research, vol 49, iss 16
Nucleic Acids Research
Nucleic Acids Research
Unequivocal functional assessment of candidate genomic regulatory regions, such as transcriptional response elements, requires genetic alteration at their native chromosomal loci. Targeted DNA cleavage by Cas9 or other programmable nucleases enables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4189f06ba74f86edb9e7040c49ea6acf
https://escholarship.org/uc/item/78m2g8wd
https://escholarship.org/uc/item/78m2g8wd
Autor:
Ramesh Ratnappan, Francis R G Amrit, Shaw-Wen Chen, Hasreet Gill, Kyle Holden, Jordan Ward, Keith R Yamamoto, Carissa P Olsen, Arjumand Ghazi
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004829 (2014)
In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that the nuclear hormone receptor, NHR-49, enables the response to this physiological change by increasing the expression of genes involved in mitochondrial β-oxid
Externí odkaz:
https://doaj.org/article/b817cd8b991d4476a246d13b6a7675ea
Glucocorticoid receptor collaborates with pioneer factors and AP-1 to execute genome-wide regulation
The glucocorticoid receptor (GR) regulates transcription through binding to specific DNA motifs, particularly at enhancers. While the motif to which it binds is constant across cell types, GR has cell type-specific binding at genomic loci, resulting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0710ee789ba1d73db95b6f0bc446072b
https://doi.org/10.1101/2021.06.01.444518
https://doi.org/10.1101/2021.06.01.444518
Autor:
Jordan D Ward, Brendan Mullaney, Benjamin J Schiller, Le D He, Sarah E Petnic, Carole Couillault, Nathalie Pujol, Teresita U Bernal, Marc R Van Gilst, Kaveh Ashrafi, Jonathan J Ewbank, Keith R Yamamoto
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92552 (2014)
Metazoan transcription factors control distinct networks of genes in specific tissues, yet understanding how these networks are integrated into physiology, development, and homeostasis remains challenging. Inactivation of the nuclear hormone receptor
Externí odkaz:
https://doaj.org/article/672348cb26964d8ab97c38820135c34d
Publikováno v:
Genetics, vol 211, iss 2
Controlling protein activity and localization is a key tool in modern biology. Mammalian steroid receptor ligand-binding domain (LBD) fusions have been used in a range of organisms and cell types to inactivate proteins of interest until the cognate s
Autor:
Jordan D Ward, Nagagireesh Bojanala, Teresita Bernal, Kaveh Ashrafi, Masako Asahina, Keith R Yamamoto
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003992 (2013)
Individual metazoan transcription factors (TFs) regulate distinct sets of genes depending on cell type and developmental or physiological context. The precise mechanisms by which regulatory information from ligands, genomic sequence elements, co-fact
Externí odkaz:
https://doaj.org/article/e23799e7bdcc4b0bb8069f74d19ba603
Autor:
Qing Li, Jon C. Aster, Hannah Yan, Joy Nakitandwe, Kevin Shannon, Robert P. Hasserjian, Alessandro Scacchetti, Jasmine C. Wong, Olga K. Weinberg, James R. Downing, Monique Dail, Anica M. Wandler, Jeffrey W. Craig, Jinghui Zhang, Lauren K. Meyer, Benjamin J. Huang, Philip Jonsson, Kathryn Hayes, Deepak Sampath, Gabriela C. Monsalve, Keith R. Yamamoto, Scott C. Kogan, Barry S. Taylor
Publikováno v:
Leukemia, vol 34, iss 8
Leukemia
Leukemia
Despite decades of clinical use, mechanisms of glucocorticoid resistance are poorly understood. We treated primary murine T lineage acute lymphoblastic leukemias (T-ALLs) with the glucocorticoid dexamethasone (DEX) alone and in combination with the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeabda681f2400375386b07498df6cf
https://escholarship.org/uc/item/7gx9m1r6
https://escholarship.org/uc/item/7gx9m1r6
Metazoan transcriptional regulatory factors (TFs) bind to genomic response elements and assemble with co-regulators into transcriptional regulatory complexes (TRCs) whose composition, structure and activities are gene-, cell- and physiological-contex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6dc5e78b8a82ca992d50fa2b77afcc
Autor:
Janet Alder, Avery August, Tracey Baas, Chelsea R. Barbercheck, Lars Berglund, Amanda Florence Bolgioni, Ashley E. Brady, Patrick D. Brandt, Patrick J. Brennwald, Abigail M. Brown, Roger Chalkley, Christine S. Chow, Rebekah St. Clair, Milagros Copara, Tamara Dahl, Laura Daniel, Steve Dewhurst, M. Isabel Dominguez, Jennie Dorman, Susan R. Engelhardt, Spencer L. Fenn, Michael J. Friedlander, David A. Fruman, Cynthia N. Fuhrmann, Kathleen L. Gould, Jennifer Greenier, Stacy Hayashi, Daniel Hidalgo, Sarah Chobot Hokanson, Brent B. Horowitz, Linda E. Hyman, Arthee Jahangir, Karen Klomparens, Mary Ellen Lane, Lorena Infante Lara, Rebekah L. Layton, Bill Lindstaedt, Heather S. Loring, Ambika Mathur, Nael A. McCarty, Julia Melkers, Frederick Meyers, Keith Micoli, Daniel Moglen, Judith A. Moldenhauer, Gabriela C. Monsalve, Sumeet Nayak, Wendy C. Newstetter, Theresa C. O'Brien, Kimberly A. Petrie, Sarah Peyre, Christine Ponder, Rachel L. Reeves, Carol Shoshkes Reiss, Julie W. Rojewski, Chris B. Schaffer, Barbara M. Schreiber, Elizabeth A. Silva, Harinder Singh, Meghan E. Spears, Jean L. Spencer, C. Abigail Stayart, Kate F.Z. Stuart, Audra Van Wart, Susi Varvayanis, Bineti Vitta, Stephanie W. Watts, Grant C. Weaver, Inge Wefes, Keith R. Yamamoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80a9d90512042646171358d2a787ce5c
https://doi.org/10.1016/b978-0-12-820759-8.01002-0
https://doi.org/10.1016/b978-0-12-820759-8.01002-0