Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Keith R, Buszek"'
Autor:
Lincoln Maina, Keith R. Buszek, Neil Brown, Nalin Chandrasoma, Diheng Luo, Alok Nerurkar, Allen Brassfield
Publikováno v:
Synthesis. 45:1843-1852
A series of related 6,7-dibromoindole compounds were prepared to study the effects of pyrrole and benzene ring substitution patterns on the regioselectivity of 6,7-indole aryne cycloadditions with 2-tert-butylfuran. The arynes were generated by our m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cf144405e4641ba4552cf12c459e0b8
https://doi.org/10.1055/s-0033-1338911
https://doi.org/10.1055/s-0033-1338911
Autor:
Neil Brown, David VanderVelde, Christopher J. Cramer, Ashley N. Garr, Diheng Luo, Keith R. Buszek
Publikováno v:
Organic Letters. 12:96-99
The 6,7-indolyne shows remarkable regioselectivity in its cycloaddition with 2-substituted furans. Electron-donating groups give predominantly the more sterically crowded product, while electron-withdrawing groups display the opposite regioselectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff63d4d1c8d3d1dfbd9173fe3ac7dc2f
https://doi.org/10.1021/ol902415s
https://doi.org/10.1021/ol902415s
Autor:
Neil J. Brown, Keith R. Buszek
Publikováno v:
Organic Letters. 9:707-710
N-Vinylpyridinium and -trialkylammonium tetrafluoroborate salts represent a new class of electrophilic coupling partner for Pd(0)-catalyzed Suzuki cross-coupling reactions and give very good to excellent yields of products with a wide range of boroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4015b80c8e4cee93043a68c91debb8dd
https://doi.org/10.1021/ol063027h
https://doi.org/10.1021/ol063027h
Publikováno v:
Tetrahedron letters. 56(23)
A practical, multi-gram 10-step synthesis of racemic herbindole A, B, and C from a common intermediate is described. The key step features a remarkably regioselective C-7 metal-halogen exchange and elimination from a Bartoli-generated N-t-butyldimeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027dc054b6a86cfb32f6bdcc34a33f41
https://pubmed.ncbi.nlm.nih.gov/26516291
https://pubmed.ncbi.nlm.nih.gov/26516291
Publikováno v:
Tetrahedron Letters. 43:181-184
A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ed3fe64e9376e413d07616ede5c187
https://doi.org/10.1016/s0040-4039(01)02078-0
https://doi.org/10.1016/s0040-4039(01)02078-0
Autor:
Neil J. Brown, Keith R. Buszek
Publikováno v:
Tetrahedron letters. 53(31)
We describe the first report of the generation of 6,7-dehydrobenzofuran (6,7-benzofuranyne) from 6,7-dihalobenzofurans via metal-halogen exchange and elimination, in a manner similar to our previous work with 6,7-indole arynes. This benzofuranyne und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c394aab8e263fd9f5383f319031ba43
https://pubmed.ncbi.nlm.nih.gov/25278635
https://pubmed.ncbi.nlm.nih.gov/25278635
Autor:
Jean-Pierre H, Perchellet, Elisabeth M, Perchellet, Chingakham Ranjit, Singh, Meghan T, Monnett, Elizabeth R, Studer, Paul D, Thornton, Neil, Brown, David, Hill, Ben, Neuenswander, Gerald H, Lushington, Conrad, Santini, Keith R, Buszek
Publikováno v:
Anticancer research. 34(4)
Synthetic 6,7-annulated-4-substituted indole compounds, which elicit interesting antitumor effects in murine L1210 leukemia cells, were tested for their ability to inhibit human HL-60 tumor cell proliferation, disrupt mitosis and cytokinesis, and int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d5d335ffe8b8319cea05501b8f2fddf
https://pubmed.ncbi.nlm.nih.gov/24692693
https://pubmed.ncbi.nlm.nih.gov/24692693
Autor:
Pedro L. Muino, Nagaaki Sato, Peter C. Still, Indranath Ghosh, Youngmee Jeong, Keith R. Buszek
Publikováno v:
Synthetic Communications. 31:1781-1791
The synthesis of functionalized saturated eight-membered ring lactones from their corresponding seco acids is a very facile process using conventional macrolactonization protocols. This heretofore unrecognized and overlooked strategy is illustrated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7ecdab8b2dc606609b782e26800dc71
https://doi.org/10.1081/scc-100104408
https://doi.org/10.1081/scc-100104408
Publikováno v:
Tetrahedron Letters. 50:63-65
The regioselectivity of Diels–Alder cycloadditions of indole arynes (indolynes) at all three benzenoid positions was examined. Cycloadditions with the 4,5-and 5,6-indolynes, derived via metal–halogen exchange from the corresponding o -dibromo ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f332ebcf180bd0b180a4ccd39b5963
https://doi.org/10.1016/j.tetlet.2008.10.086
https://doi.org/10.1016/j.tetlet.2008.10.086
Publikováno v:
Organic Letters. 9:4135-4137
Arynes derived from any position of the ubiquitous indole nucleus are unknown. We have now provided the first evidence for the formation and trapping of the 4,5-, 5,6-, and 6,7-indolynes. A series of o-dihalo indoles (Cl, Br, F) were synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8858db2d2beffce918d16b0ff511c268
https://doi.org/10.1021/ol701595n
https://doi.org/10.1021/ol701595n