Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Keith P. Smith"'
Autor:
Micah G. Donovan, Neetha P. Eduthan, Keith P. Smith, Eleanor C. Britton, Hannah R. Lyford, Paula Araya, Ross E. Granrath, Katherine A. Waugh, Belinda Enriquez Estrada, Angela L. Rachubinski, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong inter-individual variability in terms of developmental phenotypes and diagnosis of co-occurring conditions. The mechanisms underlying this variable de
Externí odkaz:
https://doaj.org/article/9c8d84e2b387481eb0fa610529c4f865
Autor:
Micah G. Donovan, Angela L. Rachubinski, Keith P. Smith, Paula Araya, Katherine A. Waugh, Belinda Enriquez-Estrada, Eleanor C. Britton, Hannah R. Lyford, Ross E. Granrath, Kyndal A. Schade, Kohl T. Kinning, Neetha Paul Eduthan, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114599- (2024)
Summary: Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions. Hypoxemia and dysregulated hematopoiesis have been doc
Externí odkaz:
https://doaj.org/article/899484d6d7604ee5ad8c1bd6d67a98fd
Autor:
Rani K. Powers, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona-Iragui, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy numbe
Externí odkaz:
https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d85
Autor:
Katherine A. Waugh, Paula Araya, Ahwan Pandey, Kimberly R. Jordan, Keith P. Smith, Ross E. Granrath, Santosh Khanal, Eric T. Butcher, Belinda Enriquez Estrada, Angela L. Rachubinski, Jennifer A. McWilliams, Ross Minter, Tiana Dimasi, Kelley L. Colvin, Dmitry Baturin, Andrew T. Pham, Matthew D. Galbraith, Kyle W. Bartsch, Michael E. Yeager, Christopher C. Porter, Kelly D. Sullivan, Elena W. Hsieh, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1893-1908.e4 (2019)
Summary: People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence of neurological and autoimmune conditions. However, the mech
Externí odkaz:
https://doaj.org/article/5e8ba4aab3a0402a9359cd3e3d5c2332
Autor:
Matthew D Galbraith, Kohl T Kinning, Kelly D Sullivan, Ryan Baxter, Paula Araya, Kimberly R Jordan, Seth Russell, Keith P Smith, Ross E Granrath, Jessica R Shaw, Monika Dzieciatkowska, Tusharkanti Ghosh, Andrew A Monte, Angelo D'Alessandro, Kirk C Hansen, Tellen D Benett, Elena WY Hsieh, Joaquín M Espinosa
Publikováno v:
eLife, Vol 10 (2021)
COVID19 is a heterogeneous medical condition involving diverse underlying pathophysiological processes including hyperinflammation, endothelial damage, thrombotic microangiopathy, and end-organ damage. Limited knowledge about the molecular mechanisms
Externí odkaz:
https://doaj.org/article/c5f457f7384b4b44a7d4aef02aa82ab3
Autor:
Roubina Tatavosian, Micah G. Donovan, Matthew D. Galbraith, Huy N. Duc, Maria M. Szwarc, Molishree U. Joshi, Amy Frieman, Ganna Bilousova, Yingqiong Cao, Keith P. Smith, Kunhua Song, Angela L. Rachubinski, Zdenek Andrysik, Joaquin M. Espinosa
Publikováno v:
Cell Death & Differentiation. 30:952-965
The p53 transcription factor is a master regulator of cellular responses to stress that is commonly inactivated in diverse cancer types. Despite decades of research, the mechanisms by which p53 impedes tumorigenesis across vastly different cellular c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e27508954d3b758d7f701bdaac2229e
https://doi.org/10.1038/s41418-023-01113-4
https://doi.org/10.1038/s41418-023-01113-4
Autor:
Marisa Gallant Stahl, Jessica R Shaw, Neetha Paul Eduthan, Angela L Rachubinski, Keith P Smith, Belinda Enriquez Estrada, Matthew D Galbraith, Ronald J Sokol, Sameer Chavan, Laura Ann Leaton, Katherine M Kichula, Paul J Norman, Jill M Norris, Edwin Liu, Joaquin M Espinosa
ObjectivesIndividuals with Down syndrome (DS) display high risk of celiac disease (CD), but the mechanisms underlying this increased susceptibility await elucidation. Here, we examined the prevalence of HLA genotypes associated with CD risk in the ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::042a99f01fa3916a7ca9b977f1767b7c
https://doi.org/10.1101/2022.09.27.22280436
https://doi.org/10.1101/2022.09.27.22280436
Autor:
Belinda Enriquez-Estrada, Jessica R Shaw, Ross E Granrath, Angela L. Rachubinski, Joaquín M. Espinosa, Kohl T Kinning, L. Alexander Liggett, James DeGregori, Matthew D. Galbraith, Kelly D. Sullivan, Keith P Smith
Publikováno v:
Blood Adv
Key Points Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba59ed3e4c4b466354c8920e49213e9
https://doi.org/10.1182/bloodadvances.2020003858
https://doi.org/10.1182/bloodadvances.2020003858
Autor:
Kelly D Sullivan, Hannah C Lewis, Amanda A Hill, Ahwan Pandey, Leisa P Jackson, Joseph M Cabral, Keith P Smith, L Alexander Liggett, Eliana B Gomez, Matthew D Galbraith, James DeGregori, Joaquín M Espinosa
Publikováno v:
eLife, Vol 5 (2016)
Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistent
Externí odkaz:
https://doaj.org/article/dcab55dc156745fda532a469ae3aaf67
Autor:
Matthew D. Galbraith, Kohl T. Kinning, Kelly D. Sullivan, Paula Araya, Keith P. Smith, Ross E. Granrath, Jessica R. Shaw, Ryan Baxter, Kimberly R. Jordan, Seth Russell, Monika Dzieciatkowska, Julie A. Reisz, Fabia Gamboni, Francesca Cendali, Tusharkanti Ghosh, Kejun Guo, Cara C. Wilson, Mario L. Santiago, Andrew A. Monte, Tellen D. Bennett, Kirk C. Hansen, Elena W. Y. Hsieh, Angelo D’Alessandro, Joaquin M. Espinosa
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both protective and harmful effects being documented. We report here a multiomics investigation of systemic IFN signaling in hospitalized COVID-19 patients, defining t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cfe4675a46c51d3ed2a429ef31c528
https://doi.org/10.1073/pnas.2116730119
https://doi.org/10.1073/pnas.2116730119