Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Keith P Smith"'
Autor:
Matthew D Galbraith, Kohl T Kinning, Kelly D Sullivan, Ryan Baxter, Paula Araya, Kimberly R Jordan, Seth Russell, Keith P Smith, Ross E Granrath, Jessica R Shaw, Monika Dzieciatkowska, Tusharkanti Ghosh, Andrew A Monte, Angelo D'Alessandro, Kirk C Hansen, Tellen D Benett, Elena WY Hsieh, Joaquín M Espinosa
Publikováno v:
eLife, Vol 10 (2021)
COVID19 is a heterogeneous medical condition involving diverse underlying pathophysiological processes including hyperinflammation, endothelial damage, thrombotic microangiopathy, and end-organ damage. Limited knowledge about the molecular mechanisms
Externí odkaz:
https://doaj.org/article/c5f457f7384b4b44a7d4aef02aa82ab3
Autor:
Nicole Luchetti, Keith M. Smith, Margherita A. G. Matarrese, Alessandro Loppini, Simonetta Filippi, Letizia Chiodo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a
Externí odkaz:
https://doaj.org/article/3f2901f6d288431f96efd49fbf9285c9
Autor:
Micah G. Donovan, Neetha P. Eduthan, Keith P. Smith, Eleanor C. Britton, Hannah R. Lyford, Paula Araya, Ross E. Granrath, Katherine A. Waugh, Belinda Enriquez Estrada, Angela L. Rachubinski, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Individuals with Down syndrome, the genetic condition caused by trisomy 21, exhibit strong inter-individual variability in terms of developmental phenotypes and diagnosis of co-occurring conditions. The mechanisms underlying this variable de
Externí odkaz:
https://doaj.org/article/9c8d84e2b387481eb0fa610529c4f865
Autor:
Kelly D Sullivan, Hannah C Lewis, Amanda A Hill, Ahwan Pandey, Leisa P Jackson, Joseph M Cabral, Keith P Smith, L Alexander Liggett, Eliana B Gomez, Matthew D Galbraith, James DeGregori, Joaquín M Espinosa
Publikováno v:
eLife, Vol 5 (2016)
Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistent
Externí odkaz:
https://doaj.org/article/dcab55dc156745fda532a469ae3aaf67
Autor:
Micah G. Donovan, Angela L. Rachubinski, Keith P. Smith, Paula Araya, Katherine A. Waugh, Belinda Enriquez-Estrada, Eleanor C. Britton, Hannah R. Lyford, Ross E. Granrath, Kyndal A. Schade, Kohl T. Kinning, Neetha Paul Eduthan, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114599- (2024)
Summary: Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions. Hypoxemia and dysregulated hematopoiesis have been doc
Externí odkaz:
https://doaj.org/article/899484d6d7604ee5ad8c1bd6d67a98fd
Autor:
Brennan Klein, Ludvig Holmér, Keith M. Smith, Mackenzie M. Johnson, Anshuman Swain, Laura Stolp, Ashley I. Teufel, April S. Kleppe
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Brennan Klein et al. propose an adapted network resilience measure, the prospective resilience (PR), to explore the resilience of protein–protein interaction networks following addition of new nodes. They apply PR to public datasets and find that r
Externí odkaz:
https://doaj.org/article/29445a7751234166a604ff210360f209
Autor:
Keith Malcolm Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Networks of disparate phenomena—be it the global ecology, human social institutions, within the human brain, or in micro-scale protein interactions—exhibit broadly consistent architectural features. To explain this, we propose a new theo
Externí odkaz:
https://doaj.org/article/8806a638a86c4cd889e213b8d3f79438
Autor:
Keith M. Smith, Javier Escudero
Publikováno v:
Applied Network Science, Vol 5, Iss 1, Pp 1-22 (2020)
Abstract Finding graph indices which are unbiased to network size and density is of high importance both within a given field and across fields for enhancing comparability of modern network science studies. The degree variance is an important metric
Externí odkaz:
https://doaj.org/article/e206dde4794b4fc5902c91a9578c9cc2
Autor:
Rani K. Powers, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona-Iragui, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy numbe
Externí odkaz:
https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d85
Autor:
Roubina Tatavosian, Micah G. Donovan, Matthew D. Galbraith, Huy N. Duc, Maria M. Szwarc, Molishree U. Joshi, Amy Frieman, Ganna Bilousova, Yingqiong Cao, Keith P. Smith, Kunhua Song, Angela L. Rachubinski, Zdenek Andrysik, Joaquin M. Espinosa
Publikováno v:
Cell Death & Differentiation. 30:952-965
The p53 transcription factor is a master regulator of cellular responses to stress that is commonly inactivated in diverse cancer types. Despite decades of research, the mechanisms by which p53 impedes tumorigenesis across vastly different cellular c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e27508954d3b758d7f701bdaac2229e
https://doi.org/10.1038/s41418-023-01113-4
https://doi.org/10.1038/s41418-023-01113-4