Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Keith P, Eidell"'
Autor:
Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of CAR-T cells and antigen escape. To investigate leukemia-intrinsic CAR-T resistance mec
Externí odkaz:
https://doaj.org/article/6711e44bcbe14aeaa34f0e56893dd8c0
Autor:
Alexander Poltorak, Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, David Jetton, Keith P. Eidell, Irina Smirnova
Publikováno v:
Science. 367:1379-1384
Macrophages cFLIP out Pathogens have evolved to survive within hosts in part by interfering with host signaling cascades. Yersinia bacteria use the effector protein YopJ to thwart MAP kinase signaling downstream of Toll-like receptor activation. In r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa130518942ad7f7b4e9bcf5841171db
https://doi.org/10.1126/science.aay3878
https://doi.org/10.1126/science.aay3878
Autor:
Stephen C. Bunnell, Keith P. Eidell, Alenka Lovy, Ken Nguyen, Frank A Scangarello, Michael J. Ophir, Maria-Cristina Seminario, Hayley I. Muendlein, Nicholas R. Sylvain
Publikováno v:
J Cell Sci
Integrin engagement within the immune synapse enhances T cell activation, but our understanding of this process is incomplete. In response to T cell receptor (TCR) ligation, SLP-76 (LCP2), ADAP (FYB1) and SKAP55 (SKAP1) are recruited into microcluste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73da64d285143d725616f1cbc35730e
https://doi.org/10.1242/jcs.258602
https://doi.org/10.1242/jcs.258602
Autor:
Hayley I, Muendlein, David, Jetton, Wilson M, Connolly, Keith P, Eidell, Zoie, Magri, Irina, Smirnova, Alexander, Poltorak
Publikováno v:
Science
Cell death and inflammation are interdependent host responses to infection. During pyroptotic cell death, interleukin-1β (IL-1β) release occurs through caspase-1 and caspase-11–mediated gasdermin D pore formation. In vivo, responses to lipopolysa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d89b3d3f6a3bcd12bce2e0efed4c2dd1
https://pubmed.ncbi.nlm.nih.gov/32193329
https://pubmed.ncbi.nlm.nih.gov/32193329
Autor:
Michael J. Ophir, Michelle O. Sodipo, Joanne M. Murphy, Juliana B. Lewis, Frank A Scangarello, Stephen C. Bunnell, Keith P. Eidell, Ryan Sargeant, Maria-Cristina Seminario
Publikováno v:
Journal of Cell Science.
Antigen recognition by the T cell receptor (TCR) directs the assembly of essential signaling complexes known as SLP-76 (also known as LCP2) microclusters. Here, we show that the interaction of the adhesion and degranulation-promoting adaptor protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c353337b10ee87ca03fbf4d1d70c907
https://doi.org/10.1242/jcs.215517
https://doi.org/10.1242/jcs.215517
Autor:
Thomas C. Chiles, Marc-Jan Gubbels, Keith P. Eidell, Paul H. Davis, Fay J. Dufort, Courtney Cronin, Sivasakthivel Thirugnanam, Lauren Jammallo, David S. Roos
Publikováno v:
Molecular and Biochemical Parasitology. 175:133-143
Toxoplasmosis is characterized by fast lytic replication cycles leading to severe tissue lesions. Successful host cell invasion is essential for pathogenesis. The division cycle of Toxoplasma gondii is characterized by an unusual cell cycle progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481cab97363c29ab25d8d3ed1004523c
https://doi.org/10.1016/j.molbiopara.2010.10.007
https://doi.org/10.1016/j.molbiopara.2010.10.007
Publikováno v:
Molecular and Biochemical Parasitology. 171:97-103
Toxoplasma gondii egress from the host cell during the lytic part of its life cycle is increasingly appreciated as a process where complex signaling mediates the parasite's response to a variety of internal and external conditions. Although several i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7264fef57818bf1a8a16121f0f8446
https://doi.org/10.1016/j.molbiopara.2010.03.004
https://doi.org/10.1016/j.molbiopara.2010.03.004
Autor:
Maestre, Fernando T.1 fernando.maestre@urjc.es, Quero, José L.1, Gotelli, Nicholas J.2, Escudero, Adrián1, Ochoa, Victoria1, Delgado-Baquerizo, Manuel3, García-Gó, Miguel1,4, Soliveres, Santiago1, Escolar, Cristina1, García-Palacios, Pablo1, Berdugo, Miguel1, Valencia, Enrique1, Gozalo, Beatriz1, Gallardo, Antonio3, Aguilera, Lorgio5, Arredondo, Tulio6, Blones, Julio7, Boeken, Bertrand8, Bran, Donaldo9, Conceição, Abel A.10
Publikováno v:
Science. 1/13/2012, Vol. 335 Issue 6065, p214-215. 5p.
A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis.
Autor:
Farrell, Andrew1, Thirugnanam, Sivasakthivel1, Lorestani, Alexander1, Dvorin, Jeffrey D.2,3, Eidell, Keith P.1, Ferguson, David J. P.4, Anderson-White, Brooke R.1, Duraisingh, Manoj T.2, Marth, Gabor T.1, Gubbels, Marc-Jan1 gubbelsj@bc.edu
Publikováno v:
Science. 1/13/2012, Vol. 335 Issue 6065, p218-221. 4p.
Publikováno v:
Hematology Week; 12/26/2023, p365-365, 1p