Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Keith N. Leppard"'
Publikováno v:
mBio, Vol 7, Iss 1 (2016)
ABSTRACT Modulation of host cell transcription, translation, and posttranslational modification processes is critical for the ability of many viruses to replicate efficiently within host cells. The human adenovirus (Ad) early region 4 open reading fr
Externí odkaz:
https://doaj.org/article/ab34c3c7e3ed4058a07a18e0529ffdbc
Autor:
Veronica Foisor, Antonia P. Sagona, Corinne J. Smith, Keith N. Leppard, Toby Ross, Dimitris K. Grammatopoulos, Christian Møller-Olsen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Bacterial neonatal meningitis results in high mortality and morbidity rates for those affected. Although improvements in diagnosis and treatment have led to a decline in mortality rates, morbidity rates have remained relatively unchanged. Bacterial r
Publikováno v:
O2, repositorio institucional de la UOC
Universitat Oberta de Catalunya (UOC)
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-10 (2021)
Universitat Oberta de Catalunya (UOC)
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-10 (2021)
BackgroundThe requirement of promyelocytic leukaemia protein (PML) in interferon (IFN)-induced cell apoptosis is well-established. However, the exact mechanisms by which the multiple isoforms of PML protein participate in this process remain not well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c31e3f2247db4ec64eaccb4acb40996
https://doi.org/10.1186/s12964-021-00756-5
https://doi.org/10.1186/s12964-021-00756-5
Deep splicing plasticity of the human adenovirus type 5 transcriptome as a driver of virus evolution
Autor:
Julian A. Hiscox, Andrew S. Turnell, I'ah Donovan-Banfield, David A. Matthews, Keith N. Leppard
Publikováno v:
Access Microbiology. 2
Viral genomes are characterised by having high gene density and complex transcription strategies. One of the most complex is adenovirus which has a double stranded DNA genome and is the archetypal viral system in which splicing was first discovered.
Autor:
Keith N. Leppard, Andrew S. Turnell, David A. Matthews, I'ah Donovan-Banfield, Julian A. Hiscox
Publikováno v:
COMMUNICATIONS BIOLOGY
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications biology, 3:124
Donovan-Banfield, IA, Turnell, A S, Hiscox, J A, Leppard, K N & Matthews, D A 2020, ' Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution ', Communications Biology, vol. 3, 124 (2020) . https://doi.org/10.1038/s42003-020-0849-9
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications biology, 3:124
Donovan-Banfield, IA, Turnell, A S, Hiscox, J A, Leppard, K N & Matthews, D A 2020, ' Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution ', Communications Biology, vol. 3, 124 (2020) . https://doi.org/10.1038/s42003-020-0849-9
Communications Biology
Viral genomes have high gene densities and complex transcription strategies rendering transcriptome analysis through short-read RNA-seq approaches problematic. Adenovirus transcription and splicing is especially complex. We used long-read direct RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179137e55caa4b52bedbd5a924eb0344
Autor:
Stefan Höning, Christina Seed, Keith N. Leppard, Sreenivasan Ponnambalam, Mark Windheim, Larissa Butler, Hans-Gerhard Burgert
Publikováno v:
Journal of Biological Chemistry. 291:6796-6812
The E3 transcription unit of human species C adenoviruses (Ads) encodes immunomodulatory proteins that mediate direct protection of infected cells. Recently, we described a novel immunomodulatory function for E3/49K, an E3 protein uniquely expressed
Publikováno v:
Vaccine
Pneumonia virus of mice (PVM) infection of BALB/c mice induces bronchiolitis leading to a fatal pneumonia in a dose-dependent manner, closely paralleling the development of severe disease during human respiratory syncytial virus infection in man, and
Praised forits clarity of presentation and accessibility, Introduction to Modern Virology has been a successful student text for over 30 years. It provides a broad introduction to virology, which includes the nature of viruses, the interaction of vir
Promyelocytic leukemia (PML) proteins have been implicated in antiviral responses but PML and associated proteins are also suggested to support virus replication. One isoform, PML-II, is required for efficient transcription of interferon and interfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2100c6614010c7e5c2b48818b587d3
http://wrap.warwick.ac.uk/79401/1/WRAP_0380721-lf-010616-atwan_pml_ad5_revised_-_wrap_copy.pdf
http://wrap.warwick.ac.uk/79401/1/WRAP_0380721-lf-010616-atwan_pml_ad5_revised_-_wrap_copy.pdf
Publikováno v:
mBio, Vol 7, Iss 1 (2016)
mBio
mBio, Vol 7, Iss 1, p e02184-15 (2016)
mBio
mBio, Vol 7, Iss 1, p e02184-15 (2016)
Modulation of host cell transcription, translation, and posttranslational modification processes is critical for the ability of many viruses to replicate efficiently within host cells. The human adenovirus (Ad) early region 4 open reading frame 3 (E4