Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Keith McKellop"'
Autor:
Keith R. Fandrick, Daniel Rivalti, Nizar Haddad, Marisa C. Kozlowski, Olga V. Zatolochnaya, Suttipol Radomkit, Scott Pennino, Nathan K. Yee, Keith McKellop, Dmitry Kurouski, Jean-Nicolas Desrosiers, Heewon Lee, Chris H. Senanayake, Soumik Biswas, Shuklendu D. Karyakarte, Jinhua J. Song, Bo Qu, Sonia Rodriguez, Hari P. R. Mangunuru, Sergei Tcyrulnikov, Joshua D. Sieber
Enantioselective synthesis of α-aryl and α-heteroaryl piperidines is reported. The key step is an iridium-catalyzed asymmetric hydrogenation of substituted N-benzyl pyridinium salts. High levels of enantioselectivity up to 99.3:0.7 er were obtained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea58d5693fceeb4c744ba3de80f4c7e0
https://europepmc.org/articles/PMC5835364/
https://europepmc.org/articles/PMC5835364/
Autor:
Keith McKellop, Bo Qu, Zhibin Li, Lalith P. Samankumara, Scott Pennino, Keith R. Fandrick, Jinhua J. Song, Zhengxu S. Han, Nizar Haddad, Shengli Ma, Sonia Rodriguez, Jean-Nicolas Desrosiers, Nina C. Gonnella, Nelu Grinberg, Chris H. Senanayake
Publikováno v:
Angewandte Chemie. 126:14656-14660
Air-stable P-chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium-catalyzed asymmetric hydrogenation of unfunctionalized 1-aryl-3,4-dihydronaphthalenes under one atmosphere pressure of H2
Autor:
Stéphane De Lombaert, Ingo Muegge, Anne Bettina Eldrup, Neil A. Farrow, David Joseph, Keith McKellop, Fariba Soleymanzadeh, Chuk Chui Man, Steven John Taylor, Alison Kukulka
Publikováno v:
Journal of Medicinal Chemistry. 52:5880-5895
Inhibition of soluble epoxide hydrolase (sEH) is hypothesized to lead to an increase in circulating levels of epoxyeicosatrienoic acids, resulting in the potentiation of their in vivo pharmacological properties. As part of an effort to identify inhib
Autor:
James O. Mullis, Keith McKellop, Alice T. Granger, Daniel L. Norwood, Fenghe Qiu, Michelle Raikes, James R. Coleman, John A. Robson
Publikováno v:
Leachables and Extractables Handbook: Safety Evaluation, Qualification, and Best Practices Applied to Inhalation Drug Products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0c42fc1c0959d2afaa60ac718e7fe9
https://doi.org/10.1002/9781118147672.ch15
https://doi.org/10.1002/9781118147672.ch15
Autor:
Scot J. Campbell, Keith McKellop, Yong Dong, Jon C. Lorenz, Fenghe Qiu, Regina C. So, Carl A. Busacca, Danja Grossbach, Ji-Young Kim, Magnus C. Eriksson, Paul-James Jones, Lana Smith, Robert D. Simpson, Robert E Harris, Jana Vitous, Earl Spinelli, Erin M O'Brien, Chiara Zavattaro
Publikováno v:
The Journal of organic chemistry. 69(16)
The Boehringer-Ingelheim phosphinoimidazoline (BIPI) ligands were applied to the formation of chiral quaternary centers in the asymmetric Heck reaction. Several different substrates were examined in detail, using more than 70 members of this new liga
Autor:
Anne B. Eldrup, Fariba Soleymanzadeh, Steven J. Taylor, Ingo Muegge, Neil A. Farrow, David Joseph, Keith McKellop, Chuk C. Man, Alison Kukulka, Stéphane De Lombaert
Publikováno v:
Journal of Medicinal Chemistry; Oct2009, Vol. 52 Issue 19, p5880-5895, 16p
Publikováno v:
Journal of Pharmaceutical Sciences. 75:886-890
The relative bioavailability of metaproterenol (3,5-dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol) following a single dose (10-mg metaproterenol sulfate tablet) was studied in six normal male volunteers using coadministration of a solution o