Výsledky vyhledávání - "Keith Martyn Dawson"

Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide

Autor: Stewart A. Cederholm-Williams, Keith Martyn Dawson, Chris P. Ponting, Charles S. Cockell, Julian M. Marshall

Human Glu-plasminogen adopts at least three conformations that provide a means for regulating the specificity of its activation in vivo. It has been proposed previously that the closed (α) conformation of human Glu-plasminogen is maintained through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c93c2ccf60f2950fd2103130ac0878
https://europepmc.org/articles/PMC1219561/

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Substitution of arginine 719 for glutamic acid in human plasminogen substantially reduces its affinity for streptokinase

Autor: Keith Martyn Dawson, Julian M. Marshall, Richard James Gilbert, Robert H. Raper, Chris P. Ponting

Publikováno v: Biochemistry. 33(40)

In isolation human plasminogen possesses no enzymatic activity, yet upon formation of an equimolar complex with the bacterial protein streptokinase, it acquires a plasminogen activator function. The region(s) of plasminogen and of streptokinase which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215af9dcbdeb28e3bca6c357cc5fa908
https://pubmed.ncbi.nlm.nih.gov/7918423

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