Výsledky vyhledávání - "Keith M. Smith"

Akademický článek

A statistical mechanics investigation of unfolded protein response across organisms

Autor: Nicole Luchetti, Keith M. Smith, Margherita A. G. Matarrese, Alessandro Loppini, Simonetta Filippi, Letizia Chiodo

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

Abstract Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a

Externí odkaz: https://doaj.org/article/3f2901f6d288431f96efd49fbf9285c9

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Akademický článek

A computational exploration of resilience and evolvability of protein–protein interaction networks

Autor: Brennan Klein, Ludvig Holmér, Keith M. Smith, Mackenzie M. Johnson, Anshuman Swain, Laura Stolp, Ashley I. Teufel, April S. Kleppe

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

Brennan Klein et al. propose an adapted network resilience measure, the prospective resilience (PR), to explore the resilience of protein–protein interaction networks following addition of new nodes. They apply PR to public datasets and find that r

Externí odkaz: https://doaj.org/article/29445a7751234166a604ff210360f209

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Akademický článek

Normalised degree variance

Autor: Keith M. Smith, Javier Escudero

Publikováno v: Applied Network Science, Vol 5, Iss 1, Pp 1-22 (2020)

Abstract Finding graph indices which are unbiased to network size and density is of high importance both within a given field and across fields for enhancing comparability of modern network science studies. The degree variance is an important metric

Externí odkaz: https://doaj.org/article/e206dde4794b4fc5902c91a9578c9cc2

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A computational exploration of resilience and evolvability of protein–protein interaction networks

Autor: Ashley I. Teufel, Laura Stolp, Ludvig Holmér, Brennan Klein, Mackenzie M. Johnson, Keith M. Smith, April S. Kleppe, Anshuman Swain

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology
Klein, B, Holmér, L, Smith, K M, Johnson, M M, Swain, A, Stolp, L, Teufel, A I & Kleppe, A S 2021, ' A computational exploration of resilience and evolvability of protein–protein interaction networks ', Communications Biology, vol. 4, no. 1, 1352 . https://doi.org/10.1038/s42003-021-02867-8

Protein–protein interaction (PPI) networks represent complex intra-cellular protein interactions, and the presence or absence of such interactions can lead to biological changes in an organism. Recent network-based approaches have shown that a phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed6d48bffe1417a2112b0c65f417b3f
https://doaj.org/article/29445a7751234166a604ff210360f209

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Classification accuracy of structural and functional connectomes across different depressive phenotypes

Autor: Hon Wah Yeung, Aleks Stolicyn, Xueyi Shen, Mark J. Adams, Liana Romaniuk, Gladi Thng, Colin R. Buchanan, Elliot M. Tucker-Drob, Mark E. Bastin, Andrew M. McIntosh, Simon R. Cox, Keith M. Smith, Heather C. Whalley

Phenotyping of major depressive disorder (MDD) in research can vary from study to study, which, together with heterogeneity of the disorder, may contribute to the inconsistent associations with various risk factors including neuroimaging features. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa5bcc679190999461bd5cea295dd2d0
https://doi.org/10.1101/2022.11.22.22282621

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A computational exploration of resilience and evolvability of protein-protein interaction networks

Autor: Ashley I. Teufel, Keith M. Smith, Laura Stolp, Mackenzie M. Johnson, Brennan Klein, April S. Kleppe, Ludvig Holmér, Anshuman Swain

Protein-protein interaction (PPI) networks represent complex intra-cellular protein interactions, and the presence or absence of such interactions can lead to biological changes in an organism. Recent network-based approaches have shown that a phenot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::769a4a1aaec987c6952ea96580e96b57
https://doi.org/10.1101/2020.07.02.184325

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A supermassive black hole awakes

Autor: Keith M. Smith

Publikováno v: Science (New York, N.Y.). 355(6327)

Active Galaxies Every large galaxy hosts a supermassive black hole at its center, which grows by consuming passing gas or stars. Most are quiescent, but when the black hole is feeding, an accretion disk forms, causing the galaxy nucleus to shine brig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ba5cb48d8deb303a90f7f81de39da0
https://pubmed.ncbi.nlm.nih.gov/28232570

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