Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Keith M. Johnson"'
Autor:
Gary Fairley, Clare Lane, Phillippa Dudley, Jason Grant Kettle, Janet Hawkins, Shaun M. Fillery, Helen Plant, Simon J. Brown, Paul Faulder, Claire Crafter, Jennifer H. Pink, Hannah Greenwood, Martin Pass, Sabina Cosulich, Barry R. Davies, Keith M. Johnson, Michael James
Publikováno v:
Journal of Medicinal Chemistry. 55:1261-1273
Wide-ranging exploration of potential replacements for a quinoline-based inhibitor of activation of AKT kinase led to number of alternative, novel scaffolds with potentially improved potency and physicochemical properties. Examples showed predictable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4440805d2b64b8e0ab58f4d09a24381f
https://doi.org/10.1021/jm201394e
https://doi.org/10.1021/jm201394e
Autor:
Peter William Rodney Caulkett, Scott Boyd, Clifford David Jones, Gordon S. Currie, Sarah Lackie, Emma Grange, Craig Johnstone, Barry R. Hayter, Harold Gaskin, Christopher D. Davies, Darren Mckerrecher, Rod B. Hargreaves, Mark L. Fenwick, Roger James, Rayner John Wall, Keith M. Johnson, Joanne V. Allen, Rolf Peter Walker, Suzanne S. Bowker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2103-2106
The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency and physical properties is discussed, and compound 22 highlighted as having a suitable balance. In vivo pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fc478426effd07bc452f839f361110
https://doi.org/10.1016/j.bmcl.2005.01.087
https://doi.org/10.1016/j.bmcl.2005.01.087
Autor:
Darren Mckerrecher, Kurt Gordon Pike, Peter William Rodney Caulkett, Ingrid Wilson, Mark L. Fenwick, Craig S. Donald, Rolf Peter Walker, David S. Clarke, Craig Johnstone, Rayner John Wall, Keith M. Johnson, Joanne V. Allen
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(11)
The continued optimization of a series of glucokinase activators is described, including attempts to understand the interplay between molecular structure and the composite parameter of unbound clearance. These studies resulted in the discovery of a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b024e61b54b6b96c4426c411f4055bb
https://pubmed.ncbi.nlm.nih.gov/21515051
https://pubmed.ncbi.nlm.nih.gov/21515051
Autor:
Kin Yip Tam, David Alan Rudge, Julie A. Tucker, Louise Moss, Barker Andrew John, Clifford David Jones, Peter B. Simpson, Alexandra McGregor, David M. Andrews, Michael A. Walker, Kevin Blades, Catherine Geh, Swain Michael Lingard, S J East, Keith M. Johnson, Heather M. McFarland, Mark A. Graham, Sarah A. Loddick, Paula Daunt
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(24)
The development of a novel series of imidazole pyrimidine amides as cyclin-dependent kinase (CDK) inhibitors is described. Optimisation of inhibitory potency against multiple CDK's (1, 2 and 9) resulted in imidazole pyrimidine amides with potent in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80517057acbe8649c1000fea635f799
https://pubmed.ncbi.nlm.nih.gov/18996007
https://pubmed.ncbi.nlm.nih.gov/18996007
Autor:
Craig Johnstone, Rolf Peter Walker, Emma Grange, Peter William Rodney Caulkett, Kurt Gordon Pike, Rayner John Wall, Craig S. Donald, Darren Mckerrecher, Mark L. Fenwick, Keith M. Johnson, Joanne V. Allen, Clifford David Jones
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(10)
The optimisation of a series of glucokinase activators is described, including attempts to uncouple the relationship between potency and plasma protein binding, and to better understand the key pharmacokinetic properties of the series. The use of unb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2f106d3ad3b29c642cf64abf17feae
https://pubmed.ncbi.nlm.nih.gov/16503142
https://pubmed.ncbi.nlm.nih.gov/16503142
Autor:
Keith M. Johnson
In the Military Health System, marketing and education about TRICARE for our active duty and retiree families needs a great deal of attention. This is a never-ending and frustrating battle. Most people are not interested in hearing about their medica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::733d595eaafcde49c588f5993acc68cb
https://doi.org/10.21236/ada420222
https://doi.org/10.21236/ada420222
Publikováno v:
Environment: Science and Policy for Sustainable Development. 22:14-41
(1980). A Closer Look at No-Till Farming. Environment: Science and Policy for Sustainable Development: Vol. 22, No. 6, pp. 14-41.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::214de1e4df23f6d870bfc73fb30bef9d
https://doi.org/10.1080/00139157.1980.9932421
https://doi.org/10.1080/00139157.1980.9932421