Výsledky vyhledávání - "Keith M. Gottesdiener"

Antagonism of the prostaglandin D 2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

Autor: Keith M. Gottesdiener, Kenneth K. Wu, Kang Cheng, Samuel D. Wright, Kathleen M. Metters, Eseng Lai, M. Gerard Waters, Claudio Sturino, Zhaoyin Wang, Tsuei-Ju Wu, Gary P. O'Neill

Publikováno v: Proceedings of the National Academy of Sciences. 103:6682-6687

Nicotinic acid (NA) is commonly used to treat dyslipidemia, but it elicits an adverse effect, termed flushing, which consists of cutaneous vasodilation with associated discomfort. An animal model of NA-induced flushing has been established in mice. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acaea11b03c50e69603800992a55f062
https://doi.org/10.1073/pnas.0601574103

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Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium

Autor: Bach-Yen T, Nguyen, Robin D, Isaacs, Hedy, Teppler, Randi Y, Leavitt, Peter, Sklar, Marian, Iwamoto, Larissa A, Wenning, Michael D, Miller, Joshua, Chen, Ramon, Kemp, Wei, Xu, Robert A, Fromtling, Joseph P, Vacca, Steven D, Young, Michael, Rowley, Michael W, Lower, Keith M, Gottesdiener, Daria J, Hazuda

Publikováno v: Annals of the New York Academy of Sciences. 1222

Raltegravir is the first integrase strand transfer inhibitor approved for the treatment of HIV-1 infection. As the first agent in this new class of antiretroviral therapies, raltegravir has demonstrated safety and efficacy in treatment-naive as well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40a8b1e3a06045aa88c5d0483d86acf3
https://pubmed.ncbi.nlm.nih.gov/21434946

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Concomitant use of the oral pentavalent human-bovine reassortant rotavirus vaccine and oral poliovirus vaccine

Autor: Guojun Yuan, Keith M. Gottesdiener, Penny M. Heaton, Max Ciarlet, Florian Schödel, José L. Arredondo, Ramei Sani-Grosso, Guanghan F. Liu

Publikováno v: The Pediatric infectious disease journal. 27(10)

OBJECTIVES The live oral pentavalent rotavirus vaccine (PRV) is well tolerated and highly efficacious against rotavirus gastroenteritis. This open-label, multicenter study evaluated the immunogenicity and safety of coadministering oral poliovirus vac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a45bdd367458551cc110b0b4b3eb8e4
https://pubmed.ncbi.nlm.nih.gov/18756184

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A dual PPAR alpha/gamma agonist increases adiponectin and improves plasma lipid profiles in healthy subjects

Autor: Katelijn, Decochez, Ronda K, Rippley, Jutta L, Miller, Marina, De Smet, Kerri X, Yan, Zissi, Matthijs, Kerry A, Riffel, Hengchang, Song, Haiyuan, Zhu, Hannah O, Maynor, Wesley, Tanaka, Amy O, Johnson-Levonas, Michael J, Davies, Keith M, Gottesdiener, Bart, Keymeulen, John A, Wagner

Publikováno v: Drugs in RD. 7(2)

The objective of these studies was to evaluate the pharmacokinetics and pharmacodynamics of MK-0767, a prototypical dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, following administration of single and multiple oral doses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c159a5b96925e7d58739f456172eba8e
https://pubmed.ncbi.nlm.nih.gov/16542056

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Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men

Autor: Marleen A, van Baak, Gabby B J, Hul, Søren, Toubro, Arne, Astrup, Keith M, Gottesdiener, Marina, DeSmet, Wim H M, Saris

Publikováno v: Clinical pharmacology and therapeutics. 71(4)

Our objective was to investigate the thermogenic efficacy of single oral doses of the novel beta(3)-adrenergic receptor agonist L-796568 [(R )-N -[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]-phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8fdec2d3776bae9f8999bab0ab0cb505
https://pubmed.ncbi.nlm.nih.gov/11956510

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T-cell receptor gene rearrangement and expression in human natural killer cells: natural killer activity is not dependent on the rearrangement and expression of T-cell receptor ?, ?, or ? genes

Autor: Jacki Kornbluth, Keith M. Gottesdiener, Alan L. Landay, Jack L. Strominger, L. R. Gottschalk, Larry A. Coury, Thomas Quertermous, Robert A. Bray, Jon G. Seidman, Howard M. Gebel, Jeffrey M. Leiden

Publikováno v: Immunogenetics. 27:231-238

To test the hypothesis that the T-cell receptor (Tcr) gamma gene encodes a natural killer (NK) cell receptor molecule, three human NK clones and fresh peripheral blood lymphocytes with NK activity from two patients with a CD16+ lymphocytosis were ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfd8359e4138a804ae1c0da1dd9e0d2
https://doi.org/10.1007/bf00376117

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Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth

Autor: Jeffrey M. Leiden, Samuel H. Speck, Martha Clabby, James A. Barbosa, Nancy H. Jones, Elizabeth Quackenbush, Keith M. Gottesdiener, Jack L. Strominger

Publikováno v: Proceedings of the National Academy of Sciences. 84:6526-6530

Complementary DNA (cDNA) clones encoding the heavy chain of the heterodimeric human membrane glycoprotein 4F2 have been isolated by immunoscreening of a lambda gt11 expression library. The identity of these clones has been confirmed by hybridization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46eb497a7edbc96af06292bfb2f65c3b
https://doi.org/10.1073/pnas.84.18.6526

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