Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Keith M. Fournier"'
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f852ee29a9488942fba6fce73ac0eaf
https://doi.org/10.1158/1535-7163.c.6543327.v1
https://doi.org/10.1158/1535-7163.c.6543327.v1
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
1. Measured pKa values of ABBV-167 (Table S1. Ionization constants of ABBV-167) 2. Preparation of ABBV-167 on large scale (Scheme S1: Synopsis of GMP synthesis of ABBV-167) 3. Preparation of clinical ABBV-167 drug supply 4. Animal pharmacokinetics (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82ad084c554229baf59a8bada6e495
https://doi.org/10.1158/1535-7163.22522290
https://doi.org/10.1158/1535-7163.22522290
Autor:
Darren C. Phillips, Gary J. Jenkins, Richard S. Hong, Chang H. Park, Richard A. Marks, Rohinton P. Edalji, Russell A. Judge, Geoff G. Z. Zhang, Nathaniel D. Catron, Jie Chen, Ahmed Salem, Ahmad Y. Sheikh, John C. Kalvass, Kaid C. Harper, Rajeev M. Menon, Kennan C. Marsh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Ahmed A. Suleiman, Yu-Ming Pu, Yi Shi, Keith M. Fournier, Zhi-Fu Tao, DeAnne Stolarik, Shuang Chen, Orlando F. Bueno, Xilu Wang, Jianguo Ji, Yi-Yin Ku, Andrew J. Souers, Joel D. Leverson, Russell C. Klix, Steven W. Elmore
Publikováno v:
Molecular cancer therapeutics. 20(6)
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Autor:
Amanda L. Sheldon, Bala T. S. Susarla, Keith M. Fournier, Marco I. González, Michael B. Robinson
Publikováno v:
Journal of Neurochemistry. 103:1917-1931
The neuronal glutamate transporter, excitatory amino acid carrier 1 (EAAC1), has a diverse array of physiologic and metabolic functions. There is evidence that there is a relatively large intracellular pool of EAAC1 both in vivo and in vitro, that EA
Autor:
Keith M. Fournier, Michael B. Robinson
Publikováno v:
Neurochemistry International. 48:596-603
A family of high-affinity transporters controls the extracellular concentration of glutamate in the brain, ensuring appropriate excitatory signaling and preventing excitotoxicity. There is evidence that one of the neuronal glutamate transporters, EAA
Publikováno v:
Journal of Biological Chemistry. 279:34505-34513
The neuronal glutamate transporter, EAAC1, appears to both limit spillover between excitatory synapses and provide precursor for the synthesis of the inhibitory neurotransmitter, γ-aminobutyric acid. There is evidence for a large intracellular pool
Publikováno v:
The Journal of Neuroscience. 24:5183-5192
Glutamate transporters may exist as homomultimers, but little is known about the mechanisms that ensure proper assembly and surface expression. In the present study, we investigated the mechanisms that contribute to posttranslational processing of th
Publikováno v:
The Journal of biological chemistry. 279(33)
The neuronal glutamate transporter, EAAC1, appears to both limit spillover between excitatory synapses and provide precursor for the synthesis of the inhibitory neurotransmitter, gamma-aminobutyric acid. There is evidence for a large intracellular po
Publikováno v:
Neuroscience research. 46(1)
POZ/BTB proteins influence cellular development and in some examples act as oncoproteins. However, several POZ/BTB transcription factors have been found in terminally differentiated neurons, where their functions remain unknown. One example is NAC1,
Autor:
Peter W. Kalivas, Keith M. Fournier, Xian-Yuan Cha, M. Scott Bowers, Mark J. Koebbe, Scott A. Mackler, Laxminarayana Korutla
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(16)
Levels of the mRNA NAC-1 are increased in the rat forebrain weeks after cocaine exposure. This long-term neuroadaptation occurs during the expression of behavioral sensitization, a model of psychostimulant-induced paranoia. NAC-1, the protein encoded