Výsledky vyhledávání - "Keith M. Borkett"

Pharmacokinetic properties of remimazolam in subjects with hepatic or renal impairment

Autor: Michel Struys, Frank Schippers, Pieter Colin, Joachim Ossig, Thomas Stöhr, Peter Winkle, Keith M. Borkett, Marija Pesic

Publikováno v: British Journal of Anaesthesia, 127(3), 415-423. ELSEVIER SCI LTD

BACKGROUND: Remimazolam is a new benzodiazepine for procedural sedation and general anaesthesia. The aim of this study was to characterise its pharmacokinetic properties and safety in renally and hepatically impaired subjects.METHODS: Two separate tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ff971bd112e1d6b9a5ac385fc52297
https://research.rug.nl/en/publications/08ea271a-a39d-4951-b17a-b0768d935b98

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A phase IIb study comparing the safety and efficacy of remimazolam and midazolam in patients undergoing colonoscopy

Autor: Karin Wilhelm-Ogunbiyi, Howard I. Schwartz, Keith M. Borkett, Timothy I. Melson, Peter Winkle, Daniel J. Pambianco, Dennis Riff

Publikováno v: Gastrointestinal Endoscopy. 83:984-992

Background and Aims Remimazolam is an ultra–short-acting benzodiazepine currently being developed for procedural sedation and for induction and maintenance of anesthesia. This trial was the fourth study for procedural sedation. The aim was to compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7832f4d100bbc279c89b2102c670c269
https://doi.org/10.1016/j.gie.2015.08.062

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Effect of escalating doses of recombinant human granulocyte colony—stimulating factor (filgrastim) on circulating neutrophils in healthy subjects

Autor: M M E Schneider, Jos van Strijp, Henk M. Vrehen, Mike Bosschaert, Jan C. C. Borleffs, Maria K. Small, Keith M. Borkett

Publikováno v: Clinical Therapeutics. 20:722-736

The safety profile, tolerability, pharmacodynamics, and pharmacokinetics of four doses of recombinant human granulocyte colony-stimulating factor (filgrastim) were assessed in healthy volunteers in a double-masked, placebo-controlled, parallel-group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5079c94626e1a2bcd7704ed7d2ca0393
https://doi.org/10.1016/s0149-2918(98)80135-5

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A phase Ib, dose-finding study of multiple doses of remimazolam (CNS 7056) in volunteers undergoing colonoscopy

Autor: Laurie J. Antonik, D. Ronald Goldwater, Keith M. Borkett, Mack C. Mitchell, James P. Lees, Mark T. Worthington, Karin Wilhelm-Ogunbiyi

Publikováno v: Anesthesia and analgesia. 117(5)

We performed the first multiple dose study of remimazolam designed to assess both the feasibility of maintaining suitable sedation during colonoscopy and reversing the sedative effects of remimazolam with flumazenil.Healthy volunteers received fentan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a1000f987f4e890f04c25bf88e5044
https://pubmed.ncbi.nlm.nih.gov/24108261

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A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part II. Population pharmacokinetic and pharmacodynamic modeling and simulation

Autor: Keith M. Borkett, Gavin J. Kilpatrick, Gary Stuart Tilbrook, Hugh Wiltshire

Publikováno v: Anesthesia and analgesia. 115(2)

A new benzodiazepine, remimazolam, which is rapidly metabolized by tissue esterases to an inactive metabolite, has been developed to permit a fast onset, a short, predictable duration of sedative action, and a more rapid recovery profile than current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00459b7f721476c262e30c8eb4e3f8bc
https://pubmed.ncbi.nlm.nih.gov/23788743

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A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. Safety, efficacy, and basic pharmacokinetics

Autor: Keith M. Borkett, Gavin J. Kilpatrick, Laurie J. Antonik, Gary Stuart Tilbrook, D. Ronald Goldwater

Publikováno v: Anesthesia and analgesia. 115(2)

A new benzodiazepine, remimazolam, metabolized by tissue esterases to an inactive compound, CNS 7054, has been developed to permit a fast onset, a short and more predictable duration of sedative action, and a more rapid recovery profile than with cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cab25e34db31f303d5c46ca4f1c259
https://pubmed.ncbi.nlm.nih.gov/22826519

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A Phase IIA, Randomized, Double-Blind Study of Remimazolam (CNS 7056) Versus Midazolam for Sedation in Upper Gastrointestinal Endoscopy

Autor: Peter Winkle, James P. Lees, Karin Wilhelm-Ogunbiyi, Daniel J. Pambianco, Howard I. Schwartz, Keith M. Borkett, Dennis Riff

Publikováno v: Survey of Anesthesiology. 59:245

This exploratory study was the first study of remimazolam in patients to assess the safety and efficacy of different single doses for procedural sedation.Patients scheduled to undergo a diagnostic upper gastrointestinal endoscopy were randomized to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1ee6ff8caeb18c99ac9890d3236b03
https://doi.org/10.1097/sa.0000000000000169

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Survival and freedom from progression in autotransplant lymphoma patients is independent of stem cell source: further follow-up from the original randomised study to assess engraftment

Autor: Panos Kottaridis, Hartmut Link, Peter Dreger, Augustin Ferrant, David C. Linch, KS Peggs, J Matcham, Keith M. Borkett, Ah Goldstone, Hilde Demuynck, Axel R. Zander, Norbert Schmitz, Marc Boogaerts

Publikováno v: Leukemialymphoma. 43(3)

Peripheral blood progenitor cells (PBPCs) have become the stem cell source of choice in autologous transplantation. In a prospective randomised trial, we previously demonstrated that autologous transplantation using filgrastim-mobilised PBPCs resulte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13d54d455340f6c6267b1b4921002d4
https://pubmed.ncbi.nlm.nih.gov/12002756

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