Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Keith M Hamel"'
Autor:
Chirag Patel, Meng Sun, Yue Liu, Jonathan Powell, Kyle Halliwill, Jennifer M Frost, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Keith M Hamel, Kira Olander, Kathleen A McGuire, Audrey J Muscato, Kelly Klinge, Joseph Klahn, Jacqueline Aguado, Payal Tiwari, Kayla J Colvin, Marcia N Paddock, Philip R Kym, Omar Avila-Monge, Alexander Schutte
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/91cbd5f2b1c44b56be7bd4787add03a6
Autor:
Wei Qiu, Qi Sun, Yi Yang, Chirag Patel, Meng Sun, Yue Liu, Kyle Halliwill, Sarah Kim, Rebecca Mathew, Jennifer M Frost, Jennifer A Roth, Domenick Kennedy, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Arvin Iracheta-Vellve, Keith M Hamel, Kira Olander, Thomas GR Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Ashwin V Kammula, Audrey J Muscato, Prasanthi Geda, Kelly Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Carey Backus, Angeline Chen, Kenton Longenecker, Joseph Klahn, Cara Hrusch, Navasona Krishnan, Charles W Hutchins, Jacqueline Aguado, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa Ronan, Meng-Ju Wu, Debattama R Sen, Gabriel K Griffin, Nabeel El-Bardeesy, Patricia Trusk, Joshua H Decker, Stacey Fossey, Marcia N Paddock, Elliot P Farney, Clay Beauregard, Philip R Kym
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/11356ff1bf1f4b63ab1324cafa253315
Autor:
Tamar Uziel, William N. Pappano, Cherrie Donawho, Joel D. Leverson, Keith M. Hamel, Ahmed Hamed Salem, Anahita Bhathena, Mark Merchant, Aparna Raval, Deepak Sampath, Christine J. Orr, Yijin Li, An D. Do, Valerie A. Robinson, Jacob J. Riehm, Nimita Dave, Yan Shi, Elisabeth A. Lasater, Rui Wang, Paul A. Ellis, Ryan Duggan, Rebecca Mathew, Dipica Haribhai, Frederick J. Kohlhapp
Supplementary Figures S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704a1bb80d5836350d691acabb9a1130
https://doi.org/10.1158/2159-8290.22536893
https://doi.org/10.1158/2159-8290.22536893
Autor:
Tamar Uziel, William N. Pappano, Cherrie Donawho, Joel D. Leverson, Keith M. Hamel, Ahmed Hamed Salem, Anahita Bhathena, Mark Merchant, Aparna Raval, Deepak Sampath, Christine J. Orr, Yijin Li, An D. Do, Valerie A. Robinson, Jacob J. Riehm, Nimita Dave, Yan Shi, Elisabeth A. Lasater, Rui Wang, Paul A. Ellis, Ryan Duggan, Rebecca Mathew, Dipica Haribhai, Frederick J. Kohlhapp
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4de11efc8dd83fcbfcc50137f10a1b
https://doi.org/10.1158/2159-8290.22536896
https://doi.org/10.1158/2159-8290.22536896
Autor:
Tamar Uziel, William N. Pappano, Cherrie Donawho, Joel D. Leverson, Keith M. Hamel, Ahmed Hamed Salem, Anahita Bhathena, Mark Merchant, Aparna Raval, Deepak Sampath, Christine J. Orr, Yijin Li, An D. Do, Valerie A. Robinson, Jacob J. Riehm, Nimita Dave, Yan Shi, Elisabeth A. Lasater, Rui Wang, Paul A. Ellis, Ryan Duggan, Rebecca Mathew, Dipica Haribhai, Frederick J. Kohlhapp
The antiapoptotic protein BCL2 plays critical roles in regulating lymphocyte development and immune responses, and has also been implicated in tumorigenesis and tumor survival. However, it is unknown whether BCL2 is critical for antitumor immune resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0751600d98b83debcbf68ebf0f510515
https://doi.org/10.1158/2159-8290.c.6548264.v1
https://doi.org/10.1158/2159-8290.c.6548264.v1
Autor:
Ahmed Salem, Yan Shi, Aparna Raval, Mark Merchant, Tamar Uziel, Frederick J. Kohlhapp, Jacob J Riehm, Deepak Sampath, Elisabeth A. Lasater, Dipica Haribhai, Joel D. Leverson, Rebecca Mathew, Valerie A. Robinson, William N. Pappano, Christine Orr, Yijin Li, Anahita Bhathena, Keith M. Hamel, Nimita Dave, An D. Do, Cherrie K. Donawho, Paul A. Ellis, Ryan Duggan, Rui Wang
Publikováno v:
Cancer Discovery. 11:68-79
The antiapoptotic protein BCL2 plays critical roles in regulating lymphocyte development and immune responses, and has also been implicated in tumorigenesis and tumor survival. However, it is unknown whether BCL2 is critical for antitumor immune resp
Autor:
Hakimeh Ebrahimi-Nik, Arvin Iracheta-Vellve, Kira E. Olander, Thomas R.G. Davis, Sarah Y. Kim, Mitchell D. Yeary, James C. Patti, Tyler M. Balon, Omar Ismail Avila, Cun Lan Chuong, Meng-Ju Wu, Christina K. Baumgartner, Keith M. Hamel, Kathleen A. McGuire, Rebecca Mathew, Carey Backus, Ian C. Kohnle, Zhaoming Xiong, Elliot P. Farney, Jennifer M. Frost, Geoff T. Halvorsen, Matthew Rees, Andrew Boghossian, Melissa Ronan, Jennifer A. Roth, Todd R. Golub, Gabriel K. Griffin, Nabeel El-Bardeesy, Clay C. Beauregard, Philip R. Kym, Kathleen B. Yates, Robert T. Manguso
Publikováno v:
Cancer Immunology Research. 10:A41-A41
Immune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatase PTPN2 is a centra
Autor:
Christina K. Baumgartner, Marcia N. Paddock, Jennifer M. Frost, Keith M. Hamel, Kathleen A. McGuire, Kyle Halliwill, Zhaoming Xiong, Liang Mu, Kelly Klinge, Prasanthi Geda, Jaqueline Aguado, Marinka Bulic, Elliot P. Farney, Kathleen B. Yates, Robert T. Manguso, Clay Beauregard, Philip R. Kym
Publikováno v:
Cancer Research. 82:ND06-ND06
Background: Pharmacologic inhibition of PTPN2 and PTPN1 (PTPN2/N1) represents a novel therapeutic approach in immuno-oncology that augments innate and adaptive immune responses in addition to enhancing tumor cell sensitivity to immune-mediated killin
Autor:
Arvin Iracheta-Vellve, Hakimeh Ebrahimi-Nik, Thomas R. Davis, Kira E. Olander, Sarah Y. Kim, Mitchell D. Yeary, James C. Patti, Ian C. Kohnle, Christina K. Baumgartner, Keith M. Hamel, Kathleen A. McGuire, Cun Lan Chuong, Zhaoming Xiong, Elliot P. Farney, Jennifer M. Frost, Matthew Rees, Andrew Boghossian, Melissa Ronan, Jennifer A. Roth, Todd R. Golub, Gabriel K. Griffin, Clay Beauregard, Philip R. Kym, Kathleen B. Yates, Robert T. Manguso
Publikováno v:
Cancer Research. 82:606-606
Immune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatase PTPN2 is a centra
Autor:
Keith M. Hamel, Balaji Manicassamy, Yao-Qing Chen, Shannon K. O’Neill, Marcus R. Clark, Roger Sciammas, Matheswaran Kandasamy, Patrick C. Wilson, Margaret Veselits, Malay Mandal, Azusa Tanaka
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 214, iss 12
The Journal of experimental medicine, vol 214, iss 12
Veselits et al. show that Igβ ubiquitination activates PI3K and the accumulation of PIP3 on BCR-associated endosomal membranes, which is necessary and sufficient for sorting into classical antigen-processing compartments. Surprisingly, proper BCR so