Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Keith M, Davies"'
Publikováno v:
The Journal of organic chemistry. 64(14)
Synthetic procedures have been devised to exploit the bifunctional amine piperazine (pip) as a linker capable of attaching the nitric oxide (NO)-releasing diazeniumdiolate functional group [N(O)NO]- to a diverse selection of biomedically useful molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca17c6fc48ecf20552b901afe27f7cd
https://pubmed.ncbi.nlm.nih.gov/34237868
https://pubmed.ncbi.nlm.nih.gov/34237868
Autor:
Stefan El-Gayar, Larry K. Keefer, Keith M. Davies, Thomas C. Wilde, Joseph E. Saavedra, Ulrike Schleicher, Michael L. Citro, Carlos A. Valdez, Jeffrey R. Deschamps, Joseph J. Barchi, Brett M. Showalter, Damon A. Parrish, Christian Bogdan
Publikováno v:
Journal of Medicinal Chemistry
Glycosylated diazeniumdiolates of structure R 2NN(O)NO-R' (R' = a saccharide residue) are potential prodrugs of the nitric oxide (NO)-releasing but acid-sensitive R 2NN(O)NO (-) ion. Moreover, cleaving the acid-stable glycosides under alkaline condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ff0d21547cc5a6315a4488cbf75975
https://doi.org/10.1021/jm8000482
https://doi.org/10.1021/jm8000482
Autor:
Mazen El-Hajj, Joseph A. Hrabie, Amr Majul, Bach T. Dinh, Stacy E. Price, Victor N. Morozov, Keith M. Davies
Publikováno v:
Nitric Oxide. 18:113-121
The effect of small unilamellar phospholipid vesicles on the acid-catalyzed dissociation of nitric oxide from diazeniumdiolate ions, R(1)R(2)N[N(O)NO](-), [1: R(1)=H(2)N(CH(2))(3)-, R(2)=H(2)N(CH(2))(3)NH(CH(2))(4)-; 2: R(1)=R(2)=H(2)N(CH(2))(3)-; 3:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d751698de87d0e4b94a8906eb559581
https://doi.org/10.1016/j.niox.2007.11.001
https://doi.org/10.1016/j.niox.2007.11.001
Autor:
Larry K. Keefer, David J. Waterhouse, Joseph Ivanic, Jack R. Collins, Gwendolyn N. Chmurny, John R. Klose, Yan Ni Wang, Judith L. Flippen-Anderson, D. Scott Bohle, Joseph E. Saavedra, Challice L. Bonifant, Keith M. Davies, Jeffrey R. Deschamps
Publikováno v:
Journal of the American Chemical Society. 127:5388-5395
Here, we explore the chemistry of the previously undocumented E form of diazeniumdiolates having the structure R(1)R(2)NN(O)=NOR(3). Reported crystallographic studies have uniformly revealed the Z configuration, and our attempts to observe a Z --> E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::475adce6238de539094708cab5840fd0
https://doi.org/10.1021/ja042258l
https://doi.org/10.1021/ja042258l
Autor:
Keith M. Davies, and Joseph A. Hrabie, Stacy E. Price, Joseph E. Saavedra, Patricia Lorenzo, Dilara Jappar
Publikováno v:
Langmuir. 19:2096-2102
The effect of surfactant micelles on the acid-catalyzed dissociation of NO from diazeniumdiolate ions of structure R1R2N[N(O)NO]- has been examined in phosphate-buffered solutions at 37 °C. The reaction behavior of zwitterionic substrates [2, R1 = R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cbc491fa10fc878c6ef8bee3fbbbc30
https://doi.org/10.1021/la020889s
https://doi.org/10.1021/la020889s
Publikováno v:
Journal of the American Chemical Society. 123:5473-5481
Diazeniumdiolate ions of structure R(2)N[N(O)NO](-) (1) are of pharmacological interest because they spontaneously generate the natural bioregulatory species, nitric oxide (NO), when dissolved in aqueous media. Here we report the kinetic details for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d375c7100ed5feb81448e6fd3ea8cb2
https://doi.org/10.1021/ja002899q
https://doi.org/10.1021/ja002899q
Autor:
Jingxi Chu, Keith M. Davies, Anna P. Shanklin, Larry K. Keefer, William G. Rice, Joseph E. Saavedra, Challice L. Bonifant, Aloka Srinivasan, Jim A. Turpin, Judith L. Flippen-Anderson
Publikováno v:
The Journal of Organic Chemistry. 66:3090-3098
Ions of structure R2N[N(O)NO]- and their alkylation products have seen increasing use as nitric oxide (NO)-generating agents for biomedical research applications. Here we show that such diazeniumdiolate anions can readily displace halide from a varie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422e47aa3966f9626398c79de94370ab
https://doi.org/10.1021/jo0016529
https://doi.org/10.1021/jo0016529
Publikováno v:
Organic Preparations and Procedures International. 31:189-192
(1999). ADDUCTS OF PIPERAZINE WITH NITRIC OXIDE. Organic Preparations and Procedures International: Vol. 31, No. 2, pp. 189-192.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90161a6b56c679685401fc7b84f9d565
https://doi.org/10.1080/00304949909355709
https://doi.org/10.1080/00304949909355709
Publikováno v:
Inorganic Chemistry. 33:1741-1747
The effect of added surfactants, sodium dodecylsulfate (SDS), Triton X-100 (C 8 H 17 C 6 H 4 (OCH 2 CH 2 ) x OH, x=9, 10), and cetyltrimethylammonium bromide (CTAB), on measured rate constants for electron transfer between Co(terpy) 2 2+ and a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c477210c648d325d9f0aa6d8aa27795a
https://doi.org/10.1021/ic00087a004
https://doi.org/10.1021/ic00087a004
Publikováno v:
Journal of physical organic chemistry. 23(3)
The kinetics of aromatic nucleophilic substitution of the nitric oxide generating diazeniumdiolate ion, DEA/NO, by thiols, (L-glutathione, L-cysteine, DL-homocysteine, 1-propanethiol, 2-mercaptoethanol and sodium thioglycolate) from the prodrug, DNP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::921ad40d35f33b1a22de1cfa62cefb64
https://pubmed.ncbi.nlm.nih.gov/21533014
https://pubmed.ncbi.nlm.nih.gov/21533014