Abstract P1-10-17: cGAS-STING driven immune activation predicts response to neoadjuvant chemotherapy and suggests rational IO combination therapies: Results of the Neo-DDIR study

Autor: Stephen J Kirk, Gemma E Logan, Steven Walker, Tong Lioe, Stuart McIntosh, Jane Hurwitz, Paul Harkin, Colin R. James, Richard D Kennedy, Laura A. Knight, Kienan Savage, Eileen Parkes, Andrena McGavigan, Keith Lowry

Publikováno v: Cancer Research. 80:P1-10

Introduction: We previously identified an immune-driven gene expression signature recognizing loss of the Fanconi Anemia/BRCA DNA repair pathway - the DNA damage immune response (DDIR) assay. This 44-gene expression-based assay predicted response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62af8b16543f008d5cbd95d299e0e6fe
https://doi.org/10.1158/1538-7445.sabcs19-p1-10-17

Digital breast tomosynthesis: sensitivity for cancer in younger symptomatic women

Autor: Patsy Whelehan, Paul Farry, Rachel Oeppen, Michaela Stahnke, Louise Wilkinson, Julie Cox, Keith Lowry, Graham Ball, Kulsam Ali, Stuart McIntosh, Maggie Jenkin, Dimitrios Zafeiris, Violet Warwick, Rachel Nutt, Jim Steel, Yee Ting Sim, Andrew Evans, Sarah Vinnicombe, Michael Reilly

Publikováno v: Whelehan, P, Ali, K, Vinnicombe, S, Ball, G, Cox, J, Farry, P, Jenkin, M, Lowry, K, McIntosh, S A, Nutt, R, Oeppen, R, Reilly, M, Stahnke, M, Steel, J, Sim, Y T, Warwick, V, Wilkinson, L, Zafeiris, D & Evans, A J 2021, ' Digital breast tomosynthesis: sensitivity for cancer in younger symptomatic women ', The British journal of radiology, pp. 20201105 . https://doi.org/10.1259/bjr.20201105
Br J Radiol

Objective: Full-field digital mammography (FFDM) has limited sensitivity for cancer in younger women with denser breasts. Digital breast tomosynthesis (DBT) can reduce the risk of cancer being obscured by overlying tissue. The primary study aim was t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946c4a4fc09d8fef46486fc9a5616836
https://pure.qub.ac.uk/en/publications/fbd24b04-60e5-4279-b505-356e750e0d21

MRI evaluation of multifocality and contralateral disease in lobular breast cancer: what can we learn from one region's experience?

Autor: Keith Lowry, Claire Magee

Publikováno v: Breast Cancer Research : BCR

Invasive lobular cancer has been associated with an increased risk of multifocal and contralateral disease. The literature suggests an incidence of contralateral disease as high as 15%. Current national (NICE) recommendations are that all patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd855b5a2f47f923d4e050bb479f7ac
http://europepmc.org/articles/PMC4670192

Book Review: Investigating Hearing in Children

Autor: J. Keith Lowry

Publikováno v: Annals of Otology, Rhinology & Laryngology. 98:575-575

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8d1921c6bb5621b080d226c1b34a97e
https://doi.org/10.1177/000348948909800717