Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Keith L. Green"'
1
Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: Synthesis and evaluation
Autor: Indrajeetsinh Sarvaiya, Eugen Barbu, Thomas G. Nevell, John Tsibouklis, Keith L. Green
Publikováno v: Journal of Biomedical Materials Research Part A. :598-606
Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d748e432b05a121dd0c419111008a7d
https://doi.org/10.1002/jbm.a.30329
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2
The gastrointestinal transit profile of 14C-labelled poly(acrylic acids)
Autor: Keith L. Green, J.Alf Davis, Frank Chadwick Hampson, Peter W. Dettmar, Robert G Riley, William R Wilber, John Tsibouklis, John D. Smart
Publikováno v: Biomaterials. 22:1861-1867
The gastrointestinal distribution profiles for three 14C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and rete
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d46b2debe5b73eaf19c7dc9f61e2a0a0
https://doi.org/10.1016/s0142-9612(00)00369-0
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3
Lectins in drug delivery: a study of the acute local irritancy of the lectins from Solanum tuberosum and Helix pomatia
Autor: John D. Cook, Tanya J. Nicholls, John D. Smart, Keith L. Green, David J. Rogers
Publikováno v: European Journal of Pharmaceutical Sciences. 9:93-98
Lectins are proteins or glycoproteins of non-immune origin capable of binding to one or more specific sugar residues. The potential for using lectins as a means of 'anchoring' a drug delivery system to the mucosal surfaces of the eye has been investi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cc99399666e34bbea5d9c15d399f35
https://doi.org/10.1016/s0928-0987(99)00050-0
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4
Preventing bacterial adhesion onto surfaces: the low-surface-energy approach
Autor: Keith L. Green, Adrian A. Thorpe, Vanessa Peters, James R. Smith, John Tsibouklis, Maureen J. Stone, Rene Heerlien, Paul Graham, Thomas G. Nevell
Publikováno v: University of Portsmouth
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Good-quality coatings prepared from poly(methylpropenoxyfluoroalkylsiloxane)s or poly(perfluoroacrylate)s are capable of inhibiting the bacterial colonisation of surfaces.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7468bfe06ecda49185f3c9e6e1106b7b
https://doi.org/10.1016/s0142-9612(99)00023-x
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5
Lectins in ocular drug delivery: An investigation of lectin binding sites on the corneal and conjunctival surfaces
Autor: David J. Rogers, John D. Smart, Tanya J. Nicholls, Sorrel Elizabeth Wolowacz, John D. Cook, Keith L. Green
Publikováno v: International Journal of Pharmaceutics. 138:175-183
Ocular drug delivery is limited both by patient acceptability and by the limited time that the dosage form is retained within the precorneal region. The aim of this investigation was to identify lectin receptors within the precorneal region as potent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c72d450d242f9d974370bdfefc0da143
https://doi.org/10.1016/0378-5173(96)04540-1
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6
Functionalized chitosan/NIPAM (HEMA) hybrid polymer networks as inserts for ocular drug delivery: synthesis, in vitro assessment, and in vivo evaluation
Autor: John Tsibouklis, Liliana Verestiuc, Oana Sorina Năstăsescu, Eugen Barbu, Indrajeetsinh Sarvaiya, Keith L. Green
Publikováno v: Journal of biomedical materials research. Part A. 77(4)
A series of hybrid polymeric hydrogels, prepared by the reaction of acrylic acid-functionalized chitosan with either N-isopropylacrylamide or 2-hydroxyethyl methacrylate monomers, were synthesized, pressed into minitablets, and investigated for their
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb88c5cae2dc3da3c54e0dfe5395c000
https://pubmed.ncbi.nlm.nih.gov/16555266
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7
A quantitative evaluation of radiolabelled lectin retention on oral mucosa in vitro and in vivo
Autor: Keith L. Green, John D. Smart, David J. Rogers, Paul K.K. Nantwi
Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 53(3)
Previous work has identified lectins that bind to the cells present on the oral mucosa for their potential use as a means of retaining a drug delivery system on the mucosal surfaces of the mouth. In this study, a radiolabelling technique was develope
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d702e30eaa8a0330887ad7a2d51567dd
https://pubmed.ncbi.nlm.nih.gov/11976016
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