Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Keith L. Black"'
Autor:
Oana M. Dumitrascu, Jonah Doustar, Dieu-Trang Fuchs, Yosef Koronyo, Dale S. Sherman, Michelle Shizu Miller, Kenneth O. Johnson, Roxana O. Carare, Steven R. Verdooner, Patrick D. Lyden, Julie A. Schneider, Keith L. Black, Maya Koronyo-Hamaoui
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract The relationship between amyloidosis and vasculature in cognitive impairment and Alzheimer’s disease (AD) pathogenesis is increasingly acknowledged. We conducted a quantitative and topographic assessment of retinal perivascular amyloid pla
Externí odkaz:
https://doaj.org/article/b8192e8cd60940848460a41ce2a8e7b8
Autor:
Liron L. Israel, Oliver Braubach, Ekaterina S. Shatalova, Oksana Chepurna, Sachin Sharma, Dmytro Klymyshyn, Anna Galstyan, Antonella Chiechi, Alysia Cox, David Herman, Bishop Bliss, Irene Hasen, Amanda Ting, Rebecca Arechavala, Michael T. Kleinman, Rameshwar Patil, Eggehard Holler, Julia Y. Ljubimova, Maya Koronyo-Hamaoui, Tao Sun, Keith L. Black
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106307- (2023)
Air pollution poses a significant threat to human health, though a clear understanding of its mechanism remains elusive. In this study, we sought to better understand the effects of various sized particulate matter from polluted air on Alzheimer's di
Externí odkaz:
https://doaj.org/article/fc013f704c85456c8aa49857e66fec8a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Naïve T cells become effector T cells following stimulation by antigen-loaded dendritic cells (DCs) and sequential cytokine activation. We aimed to develop procedures to efficiently activate T cells with tumor-associated antigens (TAAs) to
Externí odkaz:
https://doaj.org/article/a34b0fa21184463bb0f7982b02ac0ba1
Autor:
Haoshen Shi, Zhuoran Yin, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Miyah R. Davis, Jered W. Wilson, Milica A. Margeta, Kristen M. Pitts, Shawn Herron, Seiko Ikezu, Tsuneya Ikezu, Stuart L. Graham, Vivek K. Gupta, Keith L. Black, Mehdi Mirzaei, Oleg Butovsky, Maya Koronyo-Hamaoui
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Single cell RNA sequencing studies identified novel neurodegeneration-associated microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA (miR)-155 of the TREM2-APOE pathway was shown to be a key transcriptional re
Externí odkaz:
https://doaj.org/article/6295f0a29d264d44a2eee4921e0f8872
Autor:
Ron Danziger, Dieu-Trang Fuchs, Yosef Koronyo, Altan Rentsendorj, Julia Sheyn, Eric Y. Hayden, David B. Teplow, Keith L. Black, Sebastien Fuchs, Kenneth E. Bernstein, Maya Koronyo-Hamaoui
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
This review examines the role of angiotensin-converting enzyme (ACE) in the context of Alzheimer’s disease (AD) and its potential therapeutic value. ACE is known to degrade the neurotoxic 42-residue long alloform of amyloid β-protein (Aβ42), a pe
Externí odkaz:
https://doaj.org/article/b54ad841e64e40d8a609a58081f4ca5b
Autor:
Altan Rentsendorj, Koen Raedschelders, Dieu-Trang Fuchs, Julia Sheyn, Vineet Vaibhav, Rebecca A. Porritt, Haoshen Shi, Jargalsaikhan Dagvadorj, Juliana de Freitas Germano, Yosef Koronyo, Moshe Arditi, Keith L. Black, Bhakta Prasad Gaire, Jennifer E. Van Eyk, Maya Koronyo-Hamaoui
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionOsteopontin (OPN; also known as SPP1), an immunomodulatory cytokine highly expressed in bone marrow-derived macrophages (BMMΦ), is known to regulate diverse cellular and molecular immune responses. We previously revealed that glatiramer
Externí odkaz:
https://doaj.org/article/0841f2b649ca4207b40888b9d0da4ad7
Autor:
Jean-Philippe Vit, Dieu-Trang Fuchs, Ariel Angel, Aharon Levy, Itschak Lamensdorf, Keith L. Black, Yosef Koronyo, Maya Koronyo-Hamaoui
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract We introduce a novel visual-stimuli four-arm maze (ViS4M) equipped with spectrally- and intensity-controlled LED emitters and dynamic grayscale objects that relies on innate exploratory behavior to assess color and contrast vision in mice. I
Externí odkaz:
https://doaj.org/article/89ff2a0f256b4696861860d2b4d3346d
Autor:
Haoshen Shi, Yosef Koronyo, Altan Rentsendorj, Dieu-Trang Fuchs, Julia Sheyn, Keith L. Black, Nazanin Mirzaei, Maya Koronyo-Hamaoui
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The retina has been increasingly investigated as a site of Alzheimer’s disease (AD) manifestation for over a decade. Early reports documented degeneration of retinal ganglion cells and their axonal projections. Our group provided the first evidence
Externí odkaz:
https://doaj.org/article/751f43151f20454eadfd239f4d763558
Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
Autor:
Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Abstract Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood–brain barrier (BBB).
Externí odkaz:
https://doaj.org/article/094da27c385c4fb5be871715c40d5f4e
Autor:
Shouri Lahiri, Giovanna C. Regis, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Elizabeth H. Kim, Mitra Mastali, Jennifer E. Van Eyk, Padmesh S. Rajput, Patrick D. Lyden, Keith L. Black, E. Wesley Ely, Heather D. Jones, Maya Koronyo-Hamaoui
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-11 (2019)
Abstract Background Mechanical ventilation is strongly associated with cognitive decline after critical illness. This finding is particularly evident among older individuals who have pre-existing cognitive impairment, most commonly characterized by v
Externí odkaz:
https://doaj.org/article/a1f21b1a13124033987f72085d55800f