Zobrazeno 1 - 10
of 473
pro vyhledávání: '"Keith L Black"'
Autor:
Oana M. Dumitrascu, Jonah Doustar, Dieu-Trang Fuchs, Yosef Koronyo, Dale S. Sherman, Michelle Shizu Miller, Kenneth O. Johnson, Roxana O. Carare, Steven R. Verdooner, Patrick D. Lyden, Julie A. Schneider, Keith L. Black, Maya Koronyo-Hamaoui
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract The relationship between amyloidosis and vasculature in cognitive impairment and Alzheimer’s disease (AD) pathogenesis is increasingly acknowledged. We conducted a quantitative and topographic assessment of retinal perivascular amyloid pla
Externí odkaz:
https://doaj.org/article/b8192e8cd60940848460a41ce2a8e7b8
Autor:
Christine Carico, Miriam Nuño, Debraj Mukherjee, Adam Elramsisy, Jocelynn Dantis, Jethro Hu, Jeremy Rudnick, John S Yu, Keith L Black, Serguei I Bannykh, Chirag G Patil
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33684 (2012)
Pre-temozolomide studies demonstrated that loss of the tumor suppressor gene PTEN held independent prognostic significance in GBM patients. We investigated whether loss of PTEN predicted shorter survival in the temozolomide era. The role of PTEN in t
Externí odkaz:
https://doaj.org/article/7ff0af6fb2614a7da8717a35022002d8
Autor:
Satoshi Inoue, Rameshwar Patil, Jose Portilla-Arias, Hui Ding, Bindu Konda, Andres Espinoza, Dmitriy Mongayt, Janet L Markman, Adam Elramsisy, H Westley Phillips, Keith L Black, Eggehard Holler, Julia Y Ljubimova
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31070 (2012)
Treatment options for triple negative breast cancer (TNBC) are generally limited to cytotoxic chemotherapy. Recently, anti-epidermal growth factor receptor (EGFR) therapy has been introduced for TNBC patients. We engineered a novel nanobioconjugate b
Externí odkaz:
https://doaj.org/article/1689531c8e134c2cba7942819797fb11
Autor:
Dwain K Irvin, Emmanuel Jouanneau, Gretchen Duvall, Xiao-Xue Zhang, Yuying Zhai, Danielle Sarayba, Akop Seksenyan, Akanksha Panwar, Keith L Black, Christopher J Wheeler
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10974 (2010)
Small populations of highly tumorigenic stem-like cells (cancer stem cells; CSCs) can exist within, and uniquely regenerate cancers including malignant brain tumors (gliomas). Many aspects of glioma CSCs (GSCs), however, have been characterized in no
Externí odkaz:
https://doaj.org/article/d38439eed5634502a738df3a0515bb8a
Autor:
Jinwei Hu, Julia Y Ljubimova, Satoshi Inoue, Bindu Konda, Rameshwar Patil, Hui Ding, Andres Espinoza, Kolja A Wawrowsky, Chirag Patil, Alexander V Ljubimov, Keith L Black
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10108 (2010)
Chemotherapeutic drugs and newly developed therapeutic monoclonal antibodies are adequately delivered to most solid and systemic tumors. However, drug delivery into primary brain tumors and metastases is impeded by the blood-brain tumor barrier (BTB)
Externí odkaz:
https://doaj.org/article/9435b87291e747bdab8fbeb563296809
Autor:
Liron L. Israel, Oliver Braubach, Ekaterina S. Shatalova, Oksana Chepurna, Sachin Sharma, Dmytro Klymyshyn, Anna Galstyan, Antonella Chiechi, Alysia Cox, David Herman, Bishop Bliss, Irene Hasen, Amanda Ting, Rebecca Arechavala, Michael T. Kleinman, Rameshwar Patil, Eggehard Holler, Julia Y. Ljubimova, Maya Koronyo-Hamaoui, Tao Sun, Keith L. Black
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106307- (2023)
Air pollution poses a significant threat to human health, though a clear understanding of its mechanism remains elusive. In this study, we sought to better understand the effects of various sized particulate matter from polluted air on Alzheimer's di
Externí odkaz:
https://doaj.org/article/fc013f704c85456c8aa49857e66fec8a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Naïve T cells become effector T cells following stimulation by antigen-loaded dendritic cells (DCs) and sequential cytokine activation. We aimed to develop procedures to efficiently activate T cells with tumor-associated antigens (TAAs) to
Externí odkaz:
https://doaj.org/article/a34b0fa21184463bb0f7982b02ac0ba1
Autor:
Haoshen Shi, Zhuoran Yin, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Miyah R. Davis, Jered W. Wilson, Milica A. Margeta, Kristen M. Pitts, Shawn Herron, Seiko Ikezu, Tsuneya Ikezu, Stuart L. Graham, Vivek K. Gupta, Keith L. Black, Mehdi Mirzaei, Oleg Butovsky, Maya Koronyo-Hamaoui
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Single cell RNA sequencing studies identified novel neurodegeneration-associated microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA (miR)-155 of the TREM2-APOE pathway was shown to be a key transcriptional re
Externí odkaz:
https://doaj.org/article/6295f0a29d264d44a2eee4921e0f8872
Autor:
Ron Danziger, Dieu-Trang Fuchs, Yosef Koronyo, Altan Rentsendorj, Julia Sheyn, Eric Y. Hayden, David B. Teplow, Keith L. Black, Sebastien Fuchs, Kenneth E. Bernstein, Maya Koronyo-Hamaoui
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
This review examines the role of angiotensin-converting enzyme (ACE) in the context of Alzheimer’s disease (AD) and its potential therapeutic value. ACE is known to degrade the neurotoxic 42-residue long alloform of amyloid β-protein (Aβ42), a pe
Externí odkaz:
https://doaj.org/article/b54ad841e64e40d8a609a58081f4ca5b
Autor:
Altan Rentsendorj, Koen Raedschelders, Dieu-Trang Fuchs, Julia Sheyn, Vineet Vaibhav, Rebecca A. Porritt, Haoshen Shi, Jargalsaikhan Dagvadorj, Juliana de Freitas Germano, Yosef Koronyo, Moshe Arditi, Keith L. Black, Bhakta Prasad Gaire, Jennifer E. Van Eyk, Maya Koronyo-Hamaoui
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionOsteopontin (OPN; also known as SPP1), an immunomodulatory cytokine highly expressed in bone marrow-derived macrophages (BMMΦ), is known to regulate diverse cellular and molecular immune responses. We previously revealed that glatiramer
Externí odkaz:
https://doaj.org/article/0841f2b649ca4207b40888b9d0da4ad7