Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Keith K Khoo"'
Autor:
Hanumant S Tanwar, Keith K Khoo, Megan Garvey, Lynne Waddington, Andrew Leis, Marcel Hijnen, Tony Velkov, Geoff J Dumsday, William J McKinstry, Johnson Mak
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006221 (2017)
The interactions that occur during HIV Pr55Gag oligomerization and genomic RNA packaging are essential elements that facilitate HIV assembly. However, mechanistic details of these interactions are not clearly defined. Here, we overcome previous limit
Externí odkaz:
https://doaj.org/article/958df98a5bb8424bb081bb2b7192b201
Autor:
Debayan Sarkar, Iacopo Galleano, Sofie Yuewei Ou, Gül Refika Uzun, Keith K. Khoo, Gerbrand Jan van der Heden van Noort, Stephan Alexander Pless
SUMMARYAcid-sensing ion channels (ASICs) are trimeric ligand-gated ion channels that open a cation-conducting pore in response to proton-binding to their extracellular domain (ECD). This activation is typically short-lived, as channel opening is foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::645aafab1ccbb58866de60734698b339
https://doi.org/10.1101/2023.01.23.525296
https://doi.org/10.1101/2023.01.23.525296
Autor:
Keith K. Khoo, Koushik Choudhury, Hendrik Harms, Iacopo Galleano, Stephan A. Pless, Lucie Delemotte
Publikováno v:
Proceedings of the National Academy of Sciences, 118(33). NATL ACAD SCIENCES
Galleano, I, Harms, H, Choudhury, K, Khoo, K, Delemotte, L & Pless, S A 2021, ' Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na v 1.5 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 33, e2025320118 . https://doi.org/10.1073/pnas.2025320118
Galleano, I, Harms, H, Choudhury, K, Khoo, K, Delemotte, L & Pless, S A 2021, ' Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na v 1.5 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 33, e2025320118 . https://doi.org/10.1073/pnas.2025320118
The voltage-gated sodium channel Nav1.5 initiates the cardiac action potential. Alterations of its activation and inactivation properties due to mutations can cause severe, life-threatening arrhythmias. Yet despite intensive research efforts, many fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef91ad6bbdc3cca4e9360f649d423efe
https://hdl.handle.net/1887/3276853
https://hdl.handle.net/1887/3276853
Autor:
Keith K. Khoo, Stephan A. Pless, Robert Tampé, Federica Gasparri, Han Chow Chua, Matthias Wulf, Iacopo Galleano, Hendrik Harms, Ralph Wieneke, Mette H. Poulsen
Publikováno v:
Khoo, K K, Galleano, I, Gasparri, F, Wieneke, R, Harms, H, Poulsen, M H, Chua, H C, Wulf, M, Tampé, R & Pless, S A 2020, ' Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing ', Nature Communications, vol. 11, no. 1, 2284 . https://doi.org/10.1038/s41467-020-16208-6
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications, 11(1). NATURE PUBLISHING GROUP
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications, 11(1). NATURE PUBLISHING GROUP
Manipulation of proteins by chemical modification is a powerful way to decipher their function. However, most ribosome-dependent and semi-synthetic methods have limitations in the number and type of modifications that can be introduced, especially in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d108a9d73f258474fe22330eb2da4acd
https://doi.org/10.1038/s41467-020-16208-6
https://doi.org/10.1038/s41467-020-16208-6
Autor:
Tony Velkov, Mark E. Cooper, Johnson Mak, Mei-Ling Han, Elena K. Schneider, Sue C Nang, Johnny X. Huang, Vincenzo Carbone, Yan Zhu, Jian Li, Keith K. Khoo
Publikováno v:
ACS Infectious Diseases. 3:249-258
Daptomycin is a lipopeptide antibiotic that is highly bound to plasma proteins. To date, the plasma components and structure-activity relationships responsible for the plasma protein binding profile of daptomycin remain uncharacterized. In the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7eccff34761832ad7166d7d7c6daca8
https://doi.org/10.1021/acsinfecdis.7b00015
https://doi.org/10.1021/acsinfecdis.7b00015
Autor:
Koushik Choudhury, Hendrik Harms, Stephan A. Pless, Keith K. Khoo, Lucie Delemotte, Iacopo Galleano
Publikováno v:
Galleano, I, Harms, H, Choudhury, K, Khoo, K K, Delemotte, L & Pless, S A 2021, ' Interplay of Nav1.5 Disease-Causing Mutations and Phosphorylation Revealed by Protein Semi-Synthesis and Molecular Dynamics Simulations ', pp. 288A-288A . https://doi.org/10.1016/j.bpj.2020.11.1847
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c690787546ad373b4cef9aa57fcb1b
https://doi.org/10.1016/j.bpj.2020.11.1847
https://doi.org/10.1016/j.bpj.2020.11.1847
Autor:
Serena Bernacchi, Philippe Wolff, William J. McKinstry, Roland Marquet, Noé Dubois, Jean-Christophe Paillart, Tanja Seissler, Keith K. Khoo, Shannon Ghossein, Johnson Mak
Publikováno v:
RNA Biology
RNA Biology, Taylor & Francis, 2018, 15 (7), pp.923-936. ⟨10.1080/15476286.2018.1481696⟩
RNA Biology, Taylor & Francis, 2018, 15 (7), pp.923-936. ⟨10.1080/15476286.2018.1481696⟩
The Pr55(Gag) precursor specifically selects the HIV-1 genomic RNA (gRNA) from a large excess of cellular and partially or fully spliced viral RNAs and drives the virus assembly at the plasma membrane. During these processes, the NC domain of Pr55(Ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a358ff78e6c68c59aeaba4d74a2b4c
https://europepmc.org/articles/PMC6161697/
https://europepmc.org/articles/PMC6161697/
Publikováno v:
Khoo, K K, Galleano, I & Pless, S A 2019, ' A Semi-Synthetic Approach to Engineer Ligand-and Voltage-Gated Ion Channels in Live Cells ', pp. 274A-274A . https://doi.org/10.1016/j.bpj.2018.11.1482
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9737f0c2291deffaea0e64e038668d6b
https://doi.org/10.1016/j.bpj.2018.11.1482
https://doi.org/10.1016/j.bpj.2018.11.1482
Autor:
Johnson Mak, Marcel Hijnen, Geoff Dumsday, Hanumantsingh Tanwar, Lynne J. Waddington, Andrew Leis, Tony Velkov, William J. McKinstry, Megan Garvey, Keith K. Khoo
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 2, p e1006221 (2017)
PLoS Pathogens, Vol 13, Iss 2, p e1006221 (2017)
The interactions that occur during HIV Pr55Gag oligomerization and genomic RNA packaging are essential elements that facilitate HIV assembly. However, mechanistic details of these interactions are not clearly defined. Here, we overcome previous limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7ff5181add4429160d6190d2e385ef
https://pubmed.ncbi.nlm.nih.gov/28222188
https://pubmed.ncbi.nlm.nih.gov/28222188
Autor:
Keith K. Khoo, Mingyu Ye, Matthew A. Perugini, Chengwu Chi, Xiao-Xia Shao, Mi Zhou, Charles A. Galea, Shaoqiong Xu, Raymond S. Norton, Chunguang Wang, Nonlawat Boonyalai
Publikováno v:
Journal of Biological Chemistry. 287:14973-14983
Cone snail venoms are a rich source of peptides, many of which are potent and selective modulators of ion channels and receptors. Here we report the isolation and characterization of two novel conotoxins from the venom of Conus imperialis. These two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c409f4c2d395413125a03b2ff552e7a
https://doi.org/10.1074/jbc.m111.334615
https://doi.org/10.1074/jbc.m111.334615